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MDPIMDPI

8 Results Found

  • Article
  • Open Access
23 Citations
5,909 Views
14 Pages
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Untargeted HILIC-MS-Based Metabolomics Approach to Evaluate Coffee Roasting Process: Contributing to an Integrated Metabolomics Multiplatform

  • Raquel Pérez-Míguez,
  • María Castro-Puyana,
  • Elena Sánchez-López,
  • Merichel Plaza and
  • María Luisa Marina
Molecules2020, 25(4), 887;https://doi.org/10.3390/molecules25040887

17 February 2020

An untargeted metabolomics strategy using hydrophilic interaction chromatography-mass spectrometry (HILIC-MS) was developed in this work enabling the study of the coffee roasting process. Green coffee beans and coffee beans submitted to three differe...

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  • Article
  • Open Access
6 Citations
5,154 Views
18 Pages
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Plasma Metabolomic and Lipidomic Profiling of Metabolic Dysfunction-Associated Fatty Liver Disease in Humans Using an Untargeted Multiplatform Approach

  • Xiangping Lin,
  • Xinyu Liu,
  • Mohamed N. Triba,
  • Nadia Bouchemal,
  • Zhicheng Liu,
  • Douglas I. Walker,
  • Tony Palama,
  • Laurence Le Moyec,
  • Marianne Ziol and
  • Nada Helmy
  • + 4 authors
Metabolites2022, 12(11), 1081;https://doi.org/10.3390/metabo12111081

8 November 2022

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex disorder that is implicated in dysregulations in multiple biological pathways, orchestrated by interactions between genetic predisposition, metabolic syndromes and environmenta...

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  • Article
  • Open Access
10 Citations
4,789 Views
17 Pages
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Plasma Metabolome Alterations Associated with Extrauterine Growth Restriction

  • Danuta Dudzik,
  • Isabel Iglesias Platas,
  • Montserrat Izquierdo Renau,
  • Carla Balcells Esponera,
  • Beatriz del Rey Hurtado de Mendoza,
  • Carles Lerin,
  • Marta Ramón-Krauel and
  • Coral Barbas
Nutrients2020, 12(4), 1188;https://doi.org/10.3390/nu12041188

23 April 2020

Very preterm infants (VPI, born at or before 32 weeks of gestation) are at risk of adverse health outcomes, from which they might be partially protected with appropriate postnatal nutrition and growth. Metabolic processes or biochemical markers assoc...

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  • Article
  • Open Access
1,632 Views
24 Pages
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Multiplatform Metabolomic Profiling of the Unilateral Ureteral Obstruction Murine Model of CKD

  • Paula Cuevas-Delgado,
  • Verónica Miguel,
  • Santiago Lamas,
  • Coral Barbas and
  • Francisco J. Rupérez
Int. J. Mol. Sci.2025, 26(10), 4933;https://doi.org/10.3390/ijms26104933

21 May 2025

In chronic kidney disease (CKD) research, animal models such as the unilateral ureteral obstruction (UUO) rodent model are crucial to understanding disease progression, particularly renal fibrosis. Despite its widespread use, the molecular mechanisms...

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  • Open Access
2 Citations
2,371 Views
18 Pages
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Metabolome Profiling in the Plasma of Dogs with Idiopathic Dilated Cardiomyopathy: A Multiplatform Mass-Spectrometry-Based Approach

  • Ivana Rubić,
  • Stefan Weidt,
  • Richard Burchmore,
  • Alan Kovačević,
  • Josipa Kuleš,
  • Peter David Eckersall,
  • Marin Torti,
  • Ines Jović,
  • Mislav Kovačić and
  • Jelena Gotić
  • + 4 authors
Int. J. Mol. Sci.2023, 24(20), 15182;https://doi.org/10.3390/ijms242015182

14 October 2023

Dilated cardiomyopathy is one of the important diseases in dogs and humans. The second most common cause of heart failure in dogs is idiopathic dilated cardiomyopathy (iDCM), which results in heart failure or sudden cardiac death due to arrhythmia. T...

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  • Open Access
56 Citations
10,999 Views
14 Pages
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Optimization of Mobile Phase Modifiers for Fast LC-MS-Based Untargeted Metabolomics and Lipidomics

  • Tomas Cajka,
  • Jiri Hricko,
  • Lucie Rudl Kulhava,
  • Michaela Paucova,
  • Michaela Novakova and
  • Ondrej Kuda
Int. J. Mol. Sci.2023, 24(3), 1987;https://doi.org/10.3390/ijms24031987

19 January 2023

Liquid chromatography-mass spectrometry (LC-MS) is the method of choice for the untargeted profiling of biological samples. A multiplatform LC-MS-based approach is needed to screen polar metabolites and lipids comprehensively. Different mobile phase...

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  • Article
  • Open Access
11 Citations
3,739 Views
13 Pages
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Metabolomics Insights of the Immunomodulatory Activities of Phlorizin and Phloretin on Human THP-1 Macrophages

  • Noelia Cambeiro-Pérez,
  • Xiana González-Gómez,
  • Carmen González-Barreiro,
  • María Rosa Pérez-Gregorio,
  • Iva Fernandes,
  • Nuno Mateus,
  • Victor de Freitas,
  • Borja Sánchez and
  • Elena Martínez-Carballo
Molecules2021, 26(4), 787;https://doi.org/10.3390/molecules26040787

3 February 2021

Dihydrochalcones, phlorizin (PZ) and its aglycone phloretin (PT), have evidenced immunomodulatory effects through several mechanisms. However, the differential metabolic signatures that lead to these properties are largely unknown. Since macrophages...

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  • Open Access
12 Citations
3,437 Views
12 Pages
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Pre- and Post-Resection Urine Metabolic Profiles of Bladder Cancer Patients: Results of Preliminary Studies on Time Series Metabolomics Analysis

  • Julia Jacyna,
  • Marta Kordalewska,
  • Małgorzata Artymowicz,
  • Marcin Markuszewski,
  • Marcin Matuszewski and
  • Michał J. Markuszewski
Cancers2022, 14(5), 1210;https://doi.org/10.3390/cancers14051210

25 February 2022

The incidence of bladder cancer (BCa) has remained high for many years. Nevertheless, its pathomechanism has not yet been fully understood and is still being studied. Therefore, multiplatform untargeted urinary metabolomics analysis has been performe...

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