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9 Results Found

  • Article
  • Open Access
4 Citations
2,323 Views
13 Pages

Advancements in Microfluidic Cassette-Based iMiDEV™ Technology for Production of L-[11C]Methionine and [11C]Choline

  • Hemantha Mallapura,
  • Laurent Tanguy,
  • Samin Mahfuz,
  • Lovisa Bylund,
  • Bengt Långström,
  • Christer Halldin and
  • Sangram Nag

15 February 2024

Microfluidic technology is a highly efficient technique used in positron emission tomography (PET) radiochemical synthesis. This approach enables the precise control of reactant flows and reaction conditions, leading to improved yields and reduced sy...

  • Article
  • Open Access
10 Citations
3,145 Views
14 Pages

Production of [11C]Carbon Labelled Flumazenil and L-Deprenyl Using the iMiDEV™ Automated Microfluidic Radiosynthesizer

  • Hemantha Mallapura,
  • Laurent Tanguy,
  • Bengt Långström,
  • Ludovic Le Meunier,
  • Christer Halldin and
  • Sangram Nag

13 December 2022

In the last decade, microfluidic techniques have been explored in radiochemistry, and some of them have been implemented in preclinical production. However, these are not suitable and reliable for preparing different types of radiotracers or dose-on-...

  • Article
  • Open Access
14 Citations
4,682 Views
12 Pages

24 March 2021

Protein biomarkers are indicators of many diseases and are commonly used for disease diagnosis and prognosis prediction in the clinic. The urgent need for point-of-care (POC) detection of protein biomarkers has promoted the development of automated a...

  • Article
  • Open Access
6 Citations
4,401 Views
14 Pages

24 July 2024

This study presents a portable, low-cost, point-of-care (POC) system for the simultaneous detection of blood glucose and hematocrit. The system consists of a disposable origami microfluidic paper-based analytical device (μPAD) for plasma separatio...

  • Article
  • Open Access
1 Citations
2,435 Views
10 Pages

13 August 2021

Detection sensitivity of cassette PCR was compared with a commercial BAX® PCR system for detection of eae and stx genes in Escherichia coli from 806 beef carcass swabs. Cassette PCR detects multiple genetic markers on multiple samples using PCR and m...

  • Abstract
  • Open Access
1,697 Views
3 Pages

Automated Allergen Sample Preparation and Detection via Centrifugal Microfluidic Lateral Flow Assay

  • Bastian Breiner,
  • Daniel M. Kainz,
  • Stefan Wagner,
  • Maxime Gavage,
  • Serhat Sahakalkan,
  • Riccardo Marega,
  • Felix von Stetten and
  • Anna Klebes

Food allergies are a severe burden for affected individuals and healthcare systems. To tackle the need for simple food allergen detection, we developed a system for the detection of the soy protein glycinin via a centrifugal microfluidics-assisted la...

  • Article
  • Open Access
3 Citations
4,257 Views
19 Pages

[18F]fluoride Activation and 18F-Labelling in Hydrous Conditions—Towards a Microfluidic Synthesis of PET Radiopharmaceuticals

  • Olga Ovdiichuk,
  • Salla Lahdenpohja,
  • Quentin Béen,
  • Laurent Tanguy,
  • Bertrand Kuhnast and
  • Charlotte Collet-Defossez

26 December 2023

18F-labelled radiopharmaceuticals are indispensable in positron emission tomography. The critical step in the preparation of 18F-labelled tracers is the anhydrous F-18 nucleophilic substitution reaction, which involves [18F]F− anions generated...

  • Article
  • Open Access
6 Citations
3,883 Views
19 Pages

Fully Automated Macro- and Microfluidic Production of [68Ga]Ga-Citrate on mAIO® and iMiDEVTM Modules

  • Olga Ovdiichuk,
  • Emilie Roeder,
  • Sébastien Billotte,
  • Nicolas Veran and
  • Charlotte Collet

1 February 2022

68Ga-radionuclide has gained importance due to its availability via 68Ge/68Ga generator or cyclotron production, therefore increasing the number of 68Ga-based PET radiopharmaceuticals available in clinical practice. [68Ga]Ga-citrate PET has been show...

  • Article
  • Open Access
4 Citations
3,297 Views
14 Pages

Development of an Automated, Non-Enzymatic Nucleic Acid Amplification Test

  • Zackary A. Zimmers,
  • Alexander D. Boyd,
  • Hannah E. Stepp,
  • Nicholas M. Adams and
  • Frederick R. Haselton

30 September 2021

Among nucleic acid diagnostic strategies, non-enzymatic tests are the most promising for application at the point of care in low-resource settings. They remain relatively under-utilized, however, due to inadequate sensitivity. Inspired by a recent de...