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Search Results (92)

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16 pages, 3918 KB  
Article
Rethinking Manuscript Reuse: Sino-Khotanese Scrolls from Dunhuang
by Imre Galambos
Religions 2026, 17(2), 179; https://doi.org/10.3390/rel17020179 - 2 Feb 2026
Viewed by 132
Abstract
Several dozen Chinese scrolls from Dunhuang contain Khotanese writings on the verso. The contents of the Khotanese side are relatively diverse, including drafts letters and reports addressed to the Khotanese court, accounts and contracts, writing exercises, narrative works such as the Rāmāyaṇa and [...] Read more.
Several dozen Chinese scrolls from Dunhuang contain Khotanese writings on the verso. The contents of the Khotanese side are relatively diverse, including drafts letters and reports addressed to the Khotanese court, accounts and contracts, writing exercises, narrative works such as the Rāmāyaṇa and Sudhanāvadāna, lyrical poetry, medical treatises and Buddhist texts. By contrast, the Chinese side is significantly more uniform in content and appearance, comprising popular Mahāyāna scriptures copied in an even script, adhering to a regular layout. Although the Chinese sūtras were for the most part copied during the Sui-Tang era or the subsequent period of Tibetan rule over Dunhuang, the Khotanese writings seem to have been added significantly later, during the long tenth century. The reuse of Chinese Buddhist scrolls to write unrelated content—in Chinese and other languages—has typically been explained as the practice of recycling discarded manuscripts. Such explanations essentially see the Chinese sūtras on the recto as waste that was no longer wanted. This paper argues that the repurposing of Chinese scrolls could not have been exclusively motivated by paper shortage and the desire to cut costs. The paper situates this phenomenon within a broader range of reuse practices attested in Buddhist communities across Asia. The central argument advanced here is that reuse often involved a deliberate engagement with earlier textual layers, which retained aspects of their meaning even as new texts were added to the manuscript. Full article
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21 pages, 2917 KB  
Article
Application of Reactive Power Management from PV Plants into Distribution Networks: An Experimental Study and Advanced Optimization Algorithms
by Sabri Murat Kisakürek, Ahmet Serdar Yilmaz and Furkan Dinçer
Processes 2026, 14(3), 470; https://doi.org/10.3390/pr14030470 - 29 Jan 2026
Viewed by 168
Abstract
This study aims to optimize the voltage profile of the grid by obtaining an optimum level of reactive power support from photovoltaic (PV) plants, thereby enhancing the efficiency of PV systems in power distribution networks and ensuring grid stability. Initially, voltage profiles in [...] Read more.
This study aims to optimize the voltage profile of the grid by obtaining an optimum level of reactive power support from photovoltaic (PV) plants, thereby enhancing the efficiency of PV systems in power distribution networks and ensuring grid stability. Initially, voltage profiles in the sector, together with the structure and operating principles of PV plants, were considered in detail. Subsequently, the limits of reactive power support that can be provided by PV plants were determined. Then, the optimum levels of reactive power from the plants were determined using particle swarm optimization, genetic algorithm, Jaya algorithm, and firefly algorithm separately. The algorithms were tested through simulations conducted on a power distribution system operator in Türkiye. Additionally, a Modbus-based communication application was developed and tested, as a feasibility demonstration, to verify PV inverter accessibility and the capability of remotely writing reactive power reference setpoints. The quantitative optimization results reported in this manuscript are obtained from DIgSILENT PowerFactory simulations using the actual feeder model and time-series profiles. The results have revealed that PV plants can be effectively utilized as reactive power compensators to contribute to the operation of the grid under more ideal voltage profile conditions. In Türkiye, there is no regulatory or market mechanism to support reactive power provision from PV plants. Therefore, this study is novel in the Turkish market. The experimental results confirm that power generation from renewable energy can provide reactive support effectively when needed, which reveals that this approach is both technically feasible and practically relevant. Full article
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18 pages, 412 KB  
Review
Singularities and Universals: Case Reports, Clinical Trials, and an Enduring Epistemic Tension
by Carlo Galli and Marco Meleti
Histories 2026, 6(1), 11; https://doi.org/10.3390/histories6010011 - 24 Jan 2026
Viewed by 199
Abstract
This manuscript examines how distinct epistemic attitudes toward singularity and generality have been articulated in medical writing across different historical contexts, offering a conceptual and meta-historical analysis of two enduring genres in biomedical literature: the individualized case report and the systematically aggregated clinical [...] Read more.
This manuscript examines how distinct epistemic attitudes toward singularity and generality have been articulated in medical writing across different historical contexts, offering a conceptual and meta-historical analysis of two enduring genres in biomedical literature: the individualized case report and the systematically aggregated clinical trial. Hippocratic case narratives are considered as a particularly lucid articulation of a mode of inquiry that privileges detailed observation of individual patients, while medieval Aristotelian natural philosophy exemplifies a contrasting emphasis on regularity, intelligibility, and general explanation. Renaissance medical and philosophical traditions are treated as a mediating moment in which attention to anomaly, wonder, and singularity was explicitly re-legitimized within learned medicine. These historically situated articulations are not presented as stages in a progressive narrative, but as recurrent epistemic orientations that are repeatedly reconfigured under different theoretical, institutional, and technological conditions. The paper argues that the tension between attention to exceptional cases and the pursuit of generalizable knowledge continues to structure modern biomedical writing, where case reports remain essential for identifying rare, novel, or anomalous phenomena, while clinical trials formalize strategies for producing reproducible, population-level evidence. Full article
10 pages, 2137 KB  
Article
Professional Perspectives and Research Challenges Among AO CMF Surgeons in the Middle East and North Africa
by Khalid Abdel-Galil, Ammar Khalafalla and Mohamed Amir
Craniomaxillofac. Trauma Reconstr. 2026, 19(1), 5; https://doi.org/10.3390/cmtr19010005 - 19 Jan 2026
Viewed by 127
Abstract
Purpose: Research drives clinical advancement in oral and craniomaxillofacial surgery by generating evidence that guides practice and innovation. However, limited literature exists describing research engagement among surgeons within AO CMF in the Middle East and North Africa. This study evaluated awareness, participation, and [...] Read more.
Purpose: Research drives clinical advancement in oral and craniomaxillofacial surgery by generating evidence that guides practice and innovation. However, limited literature exists describing research engagement among surgeons within AO CMF in the Middle East and North Africa. This study evaluated awareness, participation, and perceived barriers to research among AO CMF members and affiliated surgeons in the MENA region. Methods: A cross-sectional, questionnaire-based survey was distributed electronically to AO CMF members, affiliates, and professional CMF surgeon networks between October and December 2024. The 14-item survey assessed demographics, research awareness, attitudes, productivity, and barriers. Responses were anonymized and analyzed descriptively using SurveyPlanet analytics. Results: A total of 144 surgeons from 21 countries completed the survey. Pakistan (35%), Morocco (9.8%), Kuwait (7.7%), and the United Arab Emirates (7%) contributed the largest proportions. Most respondents (47.6%) expressed strong interest in research but reported difficulty initiating projects, while 32.2% cited lack of time as a major constraint. The most frequently reported barriers included challenges in research methodology (14.6%), publishing (14.6%), and manuscript writing (14.1%). Only 18.9% of participants had published more than ten articles, while 29.4% had none. Mentorship demand was high (94.4%), but awareness of the AO PEER program remained limited (37.8%). Conclusion: Surgeons expressed strong enthusiasm for research yet face substantial barriers. Strengthening research methodology training, establishing structured mentorship, expanding AO PEER engagement, and facilitating multicenter collaboration are key strategies to enhance research productivity across the region. Full article
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40 pages, 486 KB  
Article
‘For We Take Our Homeland with Us, However We Change Our Sky’ — Loss, Maintenance and Identity in Early Scottish Immigrants’ Correspondence from New Zealand
by Sarah van Eyndhoven
Languages 2026, 11(1), 6; https://doi.org/10.3390/languages11010006 - 29 Dec 2025
Viewed by 380
Abstract
This contribution explores transgenerational language change in a historical migrant community by qualitatively examining the correspondence of first- and second-generation Scottish immigrants coming to New Zealand in the nineteenth century. Taking a microsocial approach, the letters of a migrant family and one other [...] Read more.
This contribution explores transgenerational language change in a historical migrant community by qualitatively examining the correspondence of first- and second-generation Scottish immigrants coming to New Zealand in the nineteenth century. Taking a microsocial approach, the letters of a migrant family and one other migrant are explored for language maintenance and shift, to identify whether Scots language features were lost altogether or continued to be utilised for specific social, personal and stylistic goals, despite the English-dominant space that the migrants operated in. In tandem, the adoption of early New Zealand English (NZE) and te reo Māori lexis is analysed, to identify differences in usage patterns that might point to different degrees of integration and mobility. Finally, inter-writer and inter-generational differences are examined in relation to the mobility and social networks of the correspondents, to consider how this might contribute to any variation observed. For the investigation, manuscript letters were digitised, and relevant features identified, extracted and discursively analysed. Results show the continuation of heritage features through a combination of style-oriented goals and learned letter-writing practices, while the adoption of new lexis is shown to occur within specific semantic domains that reflect the social mobility of the migrants. However, language maintenance and shift are not uniform between the writers, elucidating the highly variable experiences of migrants, even within the same family. Rather, contact-induced language changes are sensitive to minute differences across individuals, underpinning the value of nuanced explorations of historical migration and language change. Full article
23 pages, 418 KB  
Article
Defending the Gate of Inimitability: Abū Rashīd al-Naysābūrī (d. After 415/1024) and the Freethinker Critiques
by Omar Aladwani
Religions 2025, 16(12), 1584; https://doi.org/10.3390/rel16121584 - 17 Dec 2025
Viewed by 572
Abstract
The intellectual legacy of the Baṣrān Muʿtazila has had a profound and lasting impact on the development of discussions on Qurʾānic inimitability. Numerous writings have been composed by Baṣrān Muʿtazila on the topic; among them is Iʿjāz al-Qurʾān by Abū Rashīd al-Naysābūrī, an [...] Read more.
The intellectual legacy of the Baṣrān Muʿtazila has had a profound and lasting impact on the development of discussions on Qurʾānic inimitability. Numerous writings have been composed by Baṣrān Muʿtazila on the topic; among them is Iʿjāz al-Qurʾān by Abū Rashīd al-Naysābūrī, an unpublished manuscript preserved in the King Saud University Library under the number 7752. This paper focuses on the development of al-Naysābūrī’s understanding of Qurʾānic inimitability in the context of this manuscript, especially analysing his reception of early Muʿtazilī (specifically Bahshamī) thoughts on Qurʾānic inimitability. Moreover, it pays particular attention to al-Naysābūrī’s engagement with the critiques directed against the Bahshamī theory of Qurʾānic inimitability. This paper adopts a source-criticism approach to studying the manuscript and evaluating the historical development of its contents. It argues that the theoretical foundation underlying the theory of miraculous eloquence developed by ʿAbd al-Jabbār drew al-Naysābūrī’s attention towards a deep engagement with hypothetical dialogues inspired by the refutations of questions concerning Qurʾānic inimitability posed by the freethinkers’ movement. This engagement prompted al-Naysābūrī to adopt and assess numerous hypothetical frameworks and conditional views, including the ṣarfa theory, in his defence of Qurʾānic inimitability. This approach of addressing the freethinker critiques aligns greatly with the dynamic and responsive nature of Baṣrān Muʿtazila’s thoughts against freethinkers’ movement. Full article
17 pages, 3981 KB  
Article
Material History of Ethiopic Manuscripts: Original Repair, Damage, and Anthropogenic Impact
by Shimels Ayele Yalew, Natalia Ortega Saez, Tim De Kock, Tigab Bezie Biks, Blen Taye, Ayenew Sileshi Demssie and Abebe Dires Dinberu
Arts 2025, 14(6), 173; https://doi.org/10.3390/arts14060173 - 15 Dec 2025
Viewed by 916
Abstract
Ethiopic manuscript studies have become a rapidly expanding field in recent decades. However, most research has focused on cataloging and textual analysis. This study examines the material traces of original addenda, patterns of deterioration, and desecration of indigenous conservation ethics. A combination of [...] Read more.
Ethiopic manuscript studies have become a rapidly expanding field in recent decades. However, most research has focused on cataloging and textual analysis. This study examines the material traces of original addenda, patterns of deterioration, and desecration of indigenous conservation ethics. A combination of codicological and paleographic methods was used. This approach is vital for documenting historical features, understanding the context of use, and informing conservation efforts. The research involved assessing twenty-eight physical manuscripts from two collections in Addis Ababa, Ethiopia. Additionally, twenty-seven digital copies from the Endangered Archives Program, the Hill Museum & Manuscript Library, and the University of Cambridge Digital Library repositories were consulted. The findings revealed original features like holes, repairs, and scribal corrections. Damage such as tears, creases, dirt, fading, erasures, and recent writing was also identified. These results reveal the material history of the manuscripts. Furthermore, both domestic and international stakeholders have adversely affected these manuscripts through erasure, dispossession, and appropriation. This study proposes ethical guidelines for recent additions to the manuscripts and for preserving the original addendum. It also underscores the necessity for additional material research, enhancements in conservation practices, and efforts to raise awareness. Full article
(This article belongs to the Section Visual Arts)
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16 pages, 286 KB  
Article
Yet Before the Sins of Reading Could Be Committed Strategies of Avoidance from South Asia
by Péter Száler
Religions 2025, 16(12), 1482; https://doi.org/10.3390/rel16121482 - 23 Nov 2025
Viewed by 495
Abstract
Although similar, the terms ‘sacred text’ and ‘sacred scripture’ are not interchangeable. In my view, ‘sacred scriptures’ are physical materials that embody the transcendental words recognised as ‘sacred text’ in tangible form. Since the Abrahamic religions hold their scriptures in such high regard, [...] Read more.
Although similar, the terms ‘sacred text’ and ‘sacred scripture’ are not interchangeable. In my view, ‘sacred scriptures’ are physical materials that embody the transcendental words recognised as ‘sacred text’ in tangible form. Since the Abrahamic religions hold their scriptures in such high regard, the distinction between ‘sacred text’ and ‘sacred scripture’ becomes blurred within these traditions. By contrast, Indian religions such as Buddhism, Jainism and Hinduism seem to be more careful to maintain this distinction, as they attribute greater prestige to orality. Even when their sacred texts were written down, their main function was not usually to establish a connection between the author and the reader, i.e., to be read, but rather to be worshipped as relics. This article aims to introduce the Indian textual tradition as a possible counterpoint to the Judaeo-Christian approach. It provides a general overview of oral and manuscript culture in Indian religions and examines whether the high reverence attributed to the oral transmission, the lower prestige of the writing, and the worship of manuscripts can be understood as strategies to avoid those discrepancies, which are known as the ‘sins of reading’ (‘peccata lectionis’) in Western civilization. Full article
(This article belongs to the Special Issue Peccata Lectionis)
20 pages, 592 KB  
Review
The Temporal Evolution of Large Language Model Performance: A Comparative Analysis of Past and Current Outputs in Scientific and Medical Research
by Ishith Seth, Gianluca Marcaccini, Bryan Lim, Jennifer Novo, Stephen Bacchi, Roberto Cuomo, Richard J. Ross and Warren M. Rozen
Informatics 2025, 12(3), 86; https://doi.org/10.3390/informatics12030086 - 26 Aug 2025
Cited by 1 | Viewed by 1850
Abstract
Background: Large language models (LLMs) such as ChatGPT have evolved rapidly, with notable improvements in coherence, factual accuracy, and contextual relevance. However, their academic and clinical applicability remains under scrutiny. This study evaluates the temporal performance evolution of LLMs by comparing earlier model [...] Read more.
Background: Large language models (LLMs) such as ChatGPT have evolved rapidly, with notable improvements in coherence, factual accuracy, and contextual relevance. However, their academic and clinical applicability remains under scrutiny. This study evaluates the temporal performance evolution of LLMs by comparing earlier model outputs (GPT-3.5 and GPT-4.0) with ChatGPT-4.5 across three domains: aesthetic surgery counseling, an academic discussion base of thumb arthritis, and a systematic literature review. Methods: We replicated the methodologies of three previously published studies using identical prompts in ChatGPT-4.5. Each output was assessed against its predecessor using a nine-domain Likert-based rubric measuring factual accuracy, completeness, reference quality, clarity, clinical insight, scientific reasoning, bias avoidance, utility, and interactivity. Expert reviewers in plastic and reconstructive surgery independently scored and compared model outputs across versions. Results: ChatGPT-4.5 outperformed earlier versions across all domains. Reference quality improved most significantly (a score increase of +4.5), followed by factual accuracy (+2.5), scientific reasoning (+2.5), and utility (+2.5). In aesthetic surgery counseling, GPT-3.5 produced generic responses lacking clinical detail, whereas ChatGPT-4.5 offered tailored, structured, and psychologically sensitive advice. In academic writing, ChatGPT-4.5 eliminated reference hallucination, correctly applied evidence hierarchies, and demonstrated advanced reasoning. In the literature review, recall remained suboptimal, but precision, citation accuracy, and contextual depth improved substantially. Conclusion: ChatGPT-4.5 represents a major step forward in LLM capability, particularly in generating trustworthy academic and clinical content. While not yet suitable as a standalone decision-making tool, its outputs now support research planning and early-stage manuscript preparation. Persistent limitations include information recall and interpretive flexibility. Continued validation is essential to ensure ethical, effective use in scientific workflows. Full article
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15 pages, 26486 KB  
Article
Decorating Tibetan Buddhist Manuscripts: A Preliminary Analysis of Ornamental Writing Frames
by Michela Clemente
Religions 2025, 16(5), 582; https://doi.org/10.3390/rel16050582 - 1 May 2025
Viewed by 2219
Abstract
Buddhist books have always played a central role in the lives of Tibetan people. This is evident by looking at the hundreds of thousands of manuscripts and xylographs produced by Tibetans, and then copied, multiplied, worshipped, spread, and transmitted uninterruptedly from religious masters [...] Read more.
Buddhist books have always played a central role in the lives of Tibetan people. This is evident by looking at the hundreds of thousands of manuscripts and xylographs produced by Tibetans, and then copied, multiplied, worshipped, spread, and transmitted uninterruptedly from religious masters to disciples over the centuries. Tibetan manuscripts and xylographs have started to be studied in their entirety only recently, and the interest for their visual aspect, material features, and social life has exponentially grown, becoming crucial to progress in different fields of study, to deeply understand the way in which Tibetan Buddhist people interact with such artefacts but also to preserve a disappearing cultural heritage. This essay will focus on a so far neglected element of Tibetan Buddhist manuscripts, namely, decorations of writing frames. Any element found in a Tibetan scripture is essential from care and conservation viewpoints since it contributes to preservation for as long as possible. This is fundamental to spread Buddha’s word and to accumulate spiritual merits to progress on the path towards Enlightenment. The numerous elements exhibited in manuscripts may help locating their provenance and/or narrowing down their dating. This will also lead to a better understanding of the spread of certain scriptures within the various Tibetan areas. This essay attempts to provide a preliminary analysis of decorated writing frames found in Buddhist manuscripts produced in different periods with the twofold aim of tracing their use and codicological aspects and investigating the type of texts that were mostly chosen to be decorated as such. Full article
(This article belongs to the Special Issue Old Texts, New Insights: Exploring Buddhist Manuscripts)
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29 pages, 11350 KB  
Article
Cross-Language Transfer-Learning Approach via a Pretrained Preact ResNet-18 Architecture for Improving Kanji Recognition Accuracy and Enhancing a Number of Recognizable Kanji
by Vasyl Rusyn, Andrii Boichuk and Lesia Mochurad
Appl. Sci. 2025, 15(9), 4894; https://doi.org/10.3390/app15094894 - 28 Apr 2025
Viewed by 1105
Abstract
Many people admire the Japanese language and culture, but mastering the language’s writing system, particularly handwritten kanji, presents a significant challenge. Furthermore, translating historical manuscripts containing archaic or rare kanji requires specialized expertise. To address this, we designed a new model for handwritten [...] Read more.
Many people admire the Japanese language and culture, but mastering the language’s writing system, particularly handwritten kanji, presents a significant challenge. Furthermore, translating historical manuscripts containing archaic or rare kanji requires specialized expertise. To address this, we designed a new model for handwritten kanji recognition based on the concept of cross-language transfer learning using a Preact ResNet-18 architecture. The model was pretrained in a Chinese dataset and subsequently fine-tuned in a Japanese dataset. We also adapted and evaluated two fine-tuning strategies: unfreezing only the last layer and unfreezing all the layers during fine-tuning. During the implementation of our training algorithms, we trained a model with the CASIA-HWDB dataset with handwritten Chinese characters and used its weights to initialize models that were fine-tuned with a Kuzushiji-Kanji dataset that consists of Japanese handwritten kanji. We investigated the effectiveness of the developed model when solving a multiclass classification task for three subsets with the one hundred fifty, two hundred, and three hundred most-sampled classes and showed an improvement in the recognition accuracy and an enhancement in a number of recognizable kanji with the proposed model compared to those of the existing methods. Our best model achieved 97.94% accuracy for 150 kanji, exceeding the previous SOTA result by 1.51%, while our best model for 300 kanji achieved 97.62% accuracy (exceeding the 150-kanji SOTA accuracy by 1.19% while doubling the class count). This confirms the effectiveness of our proposed model and establishes new benchmarks in handwritten kanji recognition, both in terms of accuracy and the number of recognizable kanji. Full article
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26 pages, 769 KB  
Article
“But Who Eats the Mosquitos?”: Deaf Learners’ Language Use and Translanguaging During STEAM Discussions
by Jessica Scott, Patrick Enderle, Scott Cohen, Jasmine Smith and Reagan Hutchison
Educ. Sci. 2025, 15(5), 538; https://doi.org/10.3390/educsci15050538 - 27 Apr 2025
Viewed by 1012
Abstract
Science, technology, engineering, arts, and mathematics (STEAM) education represents an array of fields that have significant promise for the future careers of students. However, in deaf education, little research has been conducted to understand how best to provide access to STEAM learning opportunities [...] Read more.
Science, technology, engineering, arts, and mathematics (STEAM) education represents an array of fields that have significant promise for the future careers of students. However, in deaf education, little research has been conducted to understand how best to provide access to STEAM learning opportunities for deaf students. This manuscript explores STEAM learning and Deaf Education through the lens of translanguaging. Translanguaging is the use of multiple linguistic resources by multilingual individuals. The authors recorded deaf teens attending a STEAM camp as they engaged in a collaborative problem-solving activity to explore the language resources they used to make sense of and communicate their understanding of the problem during various stages of the activity (gathering information, generating ideas, and evaluating ideas). We viewed their interactions through a translanguaging lens. We found that the campers used an array of both language-based (ASL, spoken English, gesture, and fingerspelling) and tool-based (writing on a whiteboard, engaging with informational papers, using computers or phones) translanguaging activities to gather information and communicate with one another. While selection of language resources did not differ by activity stage, they did differ by group, suggesting that campers were sensitive to the communication needs of their group mates. Full article
(This article belongs to the Special Issue Full STEAM Ahead! in Deaf Education)
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24 pages, 652 KB  
Article
Fundamentals of Dual Basic Symmetric Quantum Calculus and Its Fractional Perspectives
by Muhammad Nasim Aftab, Saad Ihsan Butt and Youngsoo Seol
Fractal Fract. 2025, 9(4), 237; https://doi.org/10.3390/fractalfract9040237 - 10 Apr 2025
Cited by 2 | Viewed by 1049
Abstract
Taylor expansion is a remarkable tool with broad applications in analysis, science, engineering, and mathematics. In this manuscript, we derive a proof of generalized Taylor expansion for polynomials and write its particular case in symmetric quantum calculus. In addition, we define a novel [...] Read more.
Taylor expansion is a remarkable tool with broad applications in analysis, science, engineering, and mathematics. In this manuscript, we derive a proof of generalized Taylor expansion for polynomials and write its particular case in symmetric quantum calculus. In addition, we define a novel type of calculus that is called symmetric (p,q)- or dual basic symmetric quantum calculus. Moreover, we derive a symmetric (p,q)-Taylor expansion for polynomials based on this calculus. After that, we investigate Taylor’s formulae through an example. Furthermore, we define symmetric definite (p,q)-integral and derive a fundamental law of symmetric (p,q)-calculus. Finally, we derive the symmetric (p,q)-Cauchy formula for integrals that enables us to construct the fractional perspectives of (p,q)-symmetric integrals. Full article
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13 pages, 2101 KB  
Review
Calciphylaxis Following Parathyroidectomy in Chronic Kidney Disease Patients—Case Report and Literature Review
by Nada Akad, Stefana Catalina Bilha, Mugurel Apetrii, Fawzy Akad, Madalina Bilha, Mihai Hogas, Simona Hogas, Maria-Christina Ungureanu, Cristina Preda and Adrian Covic
Biomedicines 2025, 13(3), 715; https://doi.org/10.3390/biomedicines13030715 - 14 Mar 2025
Cited by 1 | Viewed by 3330
Abstract
Calcific uremic arteriolopathy, also known as calciphylaxis, is a rare and often fatal condition most commonly occurring in patients with end-stage renal disease (ESRD). It is marked by extensive vascular calcification, resulting in tissue ischemia and the development of distinctive skin lesions. We [...] Read more.
Calcific uremic arteriolopathy, also known as calciphylaxis, is a rare and often fatal condition most commonly occurring in patients with end-stage renal disease (ESRD). It is marked by extensive vascular calcification, resulting in tissue ischemia and the development of distinctive skin lesions. We report the case of a 38-year-old male with ESRD due to polycystic kidney disease, who developed calciphylaxis lesions following total parathyroidectomy (PTx). We also performed an electronic search of PubMed and Google Scholar from inception until December 2024, using the following keywords: ‘chronic kidney disease’, ‘dialysis’, ‘calciphylaxis’, ‘calcific uremic arteriolopathy’, ‘secondary hyperparathyroidism’, and ‘parathyroidectomy’. A literature review of calciphylaxis cases following PTx in chronic kidney disease (CKD) patients identified 14 cases reported up to the manuscript’s writing. Although PTx can be a treatment option for calciphylaxis related to severe secondary hyperparathyroidism (SHPT), leading to clinical improvement in some patients, there are atypical calciphylaxis cases occurring after PTx. While the mechanism is not fully understood, the sudden reduction in parathormone (PTH) levels leading to hypocalcemia and decreased bone turnover, together with an increased calcium loading in a patient at risk for abnormal mineralization, may promote vascular and soft tissue calcification. However, the long-term impact of severe SHPT with a delayed post-PTx manifestation cannot be ruled out. Clinicians should consider calciphylaxis in CKD patients with new painful skin lesions. Skin biopsy remains controversial, but a thorough clinical examination, and, in some cases, imaging are essential for a correct diagnosis. A multidisciplinary, personalized approach is crucial, with careful management of post-PTx hypocalcemia and calcium supplementation. Further research is needed to enhance understanding and treatment strategies. Full article
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11 pages, 1874 KB  
Review
Required, but Not Developed: Academic and Grant-Writing Skill Development on the Path to the Professoriate
by Vicki L. Baker, Staci Starck and Maria Rising
Trends High. Educ. 2025, 4(1), 14; https://doi.org/10.3390/higheredu4010014 - 7 Mar 2025
Viewed by 4305
Abstract
Scholarship and creative inquiry are a common professional responsibility across academia, regardless of institution type and geographic location. The message is clear—to advance, one must demonstrate success via various metrics such as publications, exhibitions, impact factor, citation counts, and the receipt of external [...] Read more.
Scholarship and creative inquiry are a common professional responsibility across academia, regardless of institution type and geographic location. The message is clear—to advance, one must demonstrate success via various metrics such as publications, exhibitions, impact factor, citation counts, and the receipt of external funds. Despite the importance of academic and grant writing to navigating a successful academic career, we believe there is a mismatch between that professional expectation and the corresponding supports aimed at developing these complementary, yet distinct writing skills. As such, there is an opportunity to be more intentional about fostering academic and grant-writing skill development across the various stages of a faculty career, including the doctoral student stage. In this manuscript, we present literature on academic and grant writing followed by recommendations for developing the skills needed, along with corresponding professional development opportunities that can cultivate those needed skills. We conclude with future directions. Full article
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