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Search Results (210)

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Keywords = magnetic coupling region

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15 pages, 2831 KB  
Article
Application of the Padé via Lanczos Method for Efficient Modeling of Magnetically Coupled Coils in Wireless Power Transfer Systems
by Milena Kurzawa and Rafał M. Wojciechowski
Energies 2026, 19(1), 188; https://doi.org/10.3390/en19010188 - 29 Dec 2025
Abstract
This paper presents a method for determining the equivalent circuit parameters of magnetically coupled air-core coils used in wireless power transfer (WPT) systems. The proposed approach enables fast and accurate modeling of inductively coupled energy transfer structures, which is essential for the design [...] Read more.
This paper presents a method for determining the equivalent circuit parameters of magnetically coupled air-core coils used in wireless power transfer (WPT) systems. The proposed approach enables fast and accurate modeling of inductively coupled energy transfer structures, which is essential for the design and optimization of high-efficiency wireless energy systems. The equivalent circuit of the analyzed system was developed using Cauer circuits, while a two-dimensional (2D) axisymmetric electromagnetic field model was employed to derive the equations. The model was implemented in proprietary software based on the edge-element finite element method (FEM) using the AV formulation. The AV formulation combines the magnetic vector potential A and the electric scalar potential V, enabling simultaneous representation of magnetic field distribution and current flow in conducting regions. The eddy currents in the conductors were considered in the electromagnetic field analysis. Simulations were carried out for two operating states: short-circuit and idle. The results were used to determine the parameters of the horizontal and magnetizing branches of the equivalent circuit of considered system and to analyze the frequency dependence of the resistances and inductances of the coupled coil system. The proposed modeling approach provides an effective and energy-oriented tool for the design of wireless power transfer systems with improved efficiency and reduced computational cost. The proposed method reproduces impedance characteristics with an accuracy of 0.2 × 10−3% in the idle state and 1.4 × 10−3% in the short-circuit state compared to the full FEM model, while significantly reducing the computation time. Full article
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11 pages, 1717 KB  
Article
The Transition State of PBLG Studied by Deuterium NMR
by Fabian M. Hoffmann and Burkhard Luy
Polymers 2025, 17(24), 3280; https://doi.org/10.3390/polym17243280 - 10 Dec 2025
Viewed by 347
Abstract
The liquid crystal (LC) poly-γ-benzyl-L-glutamate (PBLG) is known to possess a narrow biphasic range at the phase transition from an isotropic liquid to an anisotropic liquid crystal. We have characterized the biphasic region via deuterium nuclear magnetic resonance (NMR) of the deuterated solvent [...] Read more.
The liquid crystal (LC) poly-γ-benzyl-L-glutamate (PBLG) is known to possess a narrow biphasic range at the phase transition from an isotropic liquid to an anisotropic liquid crystal. We have characterized the biphasic region via deuterium nuclear magnetic resonance (NMR) of the deuterated solvent CDCl3, with which isotropic and anisotropic populations can unambiguously be identified and quantified due to the quadrupolar coupling induced by partial alignment. In addition to a dilution series, we measured the kinetics of the alignment inside the magnet for each dilution step and were able to follow the kinetic buildup of partial alignment. Beginning with the dynamic line broadening indicative of slow fluctuations, to microheterogeneous patches of isotropic and anisotropic islands, with increasing island size being consistent with sharpened spectra, ending in fully separated isotropic and anisotropic phases on top of each other after two weeks. In addition, we studied the influence of the two example guest molecules borneol and camphor—which essentially differ in their capability to act as hydrogen bond donors or acceptors—on the biphasic region of PBLG. Full article
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30 pages, 10674 KB  
Article
Analysis of the Demagnetization of a PMSG Using a Coupled Electromagnetic–Fluid–Thermal Numerical Model
by Jorge E. Morón-Monreal, Francisco J. Martinez-Rios, Concepcion Hernandez and Marco A. Arjona
Energies 2025, 18(23), 6149; https://doi.org/10.3390/en18236149 - 24 Nov 2025
Viewed by 422
Abstract
This article presents a multiphysics simulation methodology to predict the temperature-dependent demagnetization phenomenon of a 900 W permanent-magnet synchronous generator (PMSG). For the 2D electromagnetic model, a commercial finite element method (FEM) package was used to determine the power loss distribution under steady-state [...] Read more.
This article presents a multiphysics simulation methodology to predict the temperature-dependent demagnetization phenomenon of a 900 W permanent-magnet synchronous generator (PMSG). For the 2D electromagnetic model, a commercial finite element method (FEM) package was used to determine the power loss distribution under steady-state conditions, accounting for temperature-dependent demagnetization. The thermal analysis was carried out on a 3D model using computational fluid dynamics (CFD) software, where a polyhedral mesh, rotor rotation effects, and turbulent modeling were implemented. Two simulation cases were evaluated: Case 1, electromagnetic losses at constant temperature without FEM-CFD coupling; Case 2, bidirectional FEM-CFD coupling under steady-state conditions. The analysis confirms that in Cases 1 and 2, there is no risk of irreversible demagnetization, thus validating the selection of the permanent magnet (PM) and the design of the PMSG. Additionally, the methodology accurately captured the heat transfer effects resulting from natural convection and turbulent flow in the critical regions. The CFD modeling convergence criteria, based on residuals and flow monitors, demonstrated numerical stability and a satisfactory mesh discretization in both the FEM and CFD domains, providing valid feedback on the PM temperatures. The proposed methodology provides a robust and accurate tool for coupled electromagnetic–fluid–thermal analysis of the PMSG at rated operating conditions. Full article
(This article belongs to the Special Issue Advances in Permanent Magnet Synchronous Generator)
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26 pages, 10195 KB  
Article
Regional Characteristics of Geomagnetic Activity: Comparative Analysis of Local K and Global Kp Indices
by Vitaliy Kapytin, Alexey Andreyev, Vyacheslav Somsikov, Beibit Zhumabayev, Saule Mukasheva, Yekaterina Chsherbulova and Stanislav Utebayev
Atmosphere 2025, 16(12), 1319; https://doi.org/10.3390/atmos16121319 - 22 Nov 2025
Viewed by 492
Abstract
Geomagnetic activity reflects the complex coupling between the solar wind, magneto-sphere and ionosphere. While the global Kp index serves as a standard proxy for geo-magnetic disturbances, it obscures regional variations linked to local current systems and ionospheric conductivity. This study investigates regional features [...] Read more.
Geomagnetic activity reflects the complex coupling between the solar wind, magneto-sphere and ionosphere. While the global Kp index serves as a standard proxy for geo-magnetic disturbances, it obscures regional variations linked to local current systems and ionospheric conductivity. This study investigates regional features of geomagnetic activity using the local K index from the Almaty (AAA) observatory and compares its temporal dynamics with Kp for 2007–2025. A combination of statistical, spectral, wavelet, and nonlinear methods was applied, including power spectral density, continuous and cross-wavelet transforms, multifractal detrended fluctuation analysis, and permutation entropy. These approaches capture both linear and nonlinear features of variability and reveal scale-dependent structures in geomagnetic fluctuations. The results show a high correlation (r ≈ 0.84) between K (AAA) and Kp, but with a consistent positive offset of the local index, indicating sensitivity to regional ionospheric processes. Wavelet coherence highlights strong coupling in the 13–27-day band associated with solar rotation. Multifractal spectra reveal broader, more heterogeneous scaling in Kp and narrower, more intermittent dynamics in K during disturbed periods. Local indices, like K (AAA), thus provide essential insight into mid-latitude electrodynamics, complementing global measures in characterizing the nonlinear spatio-temporal complexity of geomagnetic activity. Full article
(This article belongs to the Section Upper Atmosphere)
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19 pages, 7766 KB  
Article
Effects of Ion Drag on Ionospheric Gravity Waves in the Presence of a Strong Constant Magnetic Field
by Victor Nijimbere, Martin Nadon and Lucy J. Campbell
Atmosphere 2025, 16(11), 1275; https://doi.org/10.3390/atmos16111275 - 10 Nov 2025
Viewed by 271
Abstract
A temporally periodic model is presented to describe the vertical profile of internal gravity waves in the F region of the Earth’s ionosphere where the waves are subject to a magnetic force due to the high concentration of ions. The configuration studied is [...] Read more.
A temporally periodic model is presented to describe the vertical profile of internal gravity waves in the F region of the Earth’s ionosphere where the waves are subject to a magnetic force due to the high concentration of ions. The configuration studied is representative of the situation where the geomagnetic field is approximately constant and is so strong that the angular gyrofrequency of the ions is very large compared with the ion-neutral collision frequency, which is in turn larger than the angular frequency of the gravity waves. We examine the situation where the gravity wave amplitude is small enough that the equations for the neutral fluid flow can be linearized. This allows for the description of wave propagation in terms of a system of coupled equations that include the effects of ion drag on waves for any orientation of the magnetic field. It is assumed that the background neutral fluid flow is nonzero and horizontal, but there is no vertical shear, and that the wave amplitude depends on altitude only, and an exact analytical solution is readily found. This dynamical model captures some essential features of ionospheric gravity waves that are consistent with observational measurements. In particular, the ion drag acts to damp the waves in the direction of vertical propagation and increase their vertical wavelength relative to the corresponding wavelength in the neutral atmosphere. The vertical damping rate and the vertical wavelength both depend on the dip angle of the magnetic field. When the magnetic field acts in the direction of the gravity lines of constant phase, there is no damping, and the vertical wavelength is the same as that of the corresponding waves in the neutral atmosphere. The dip angles that produce stronger damping also result in waves with greater wavelengths. Full article
(This article belongs to the Special Issue Exploring the Earth's Ionosphere with a Dynamical Systems Approach)
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10 pages, 6055 KB  
Proceeding Paper
WISPFI Experiment: Prototype Development
by Josep Maria Batllori, Michael H. Frosz, Dieter Horns and Marios Maroudas
Phys. Sci. Forum 2025, 11(1), 4; https://doi.org/10.3390/psf2025011004 - 31 Oct 2025
Viewed by 289
Abstract
Axions and axion-like particles (ALPs) are well-motivated dark matter (DM) candidates that couple with photons in external magnetic fields. The parameter space around m a 50 meV remains largely unexplored by haloscope experiments. We present the first prototype of Weakly Interacting Sub-eV [...] Read more.
Axions and axion-like particles (ALPs) are well-motivated dark matter (DM) candidates that couple with photons in external magnetic fields. The parameter space around m a 50 meV remains largely unexplored by haloscope experiments. We present the first prototype of Weakly Interacting Sub-eV Particles (WISP) Searches on a Fiber Interferometer (WISPFI), a table-top, model-independent scheme based on resonant photon–axion conversion in a hollow-core photonic crystal fiber (HC-PCF) integrated into a Mach–Zehnder interferometer (MZI). Operating near a dark fringe with active phase-locking, combined with amplitude modulation, the interferometer converts axion-induced photon disappearance into a measurable signal. A 2 W, 1550 nm laser is coupled with a 1 m-long HC-PCF placed inside a ∼2 T permanent magnet array, probing a fixed axion mass of m a 49 meV with a projected sensitivity of g a γ γ 1.3× 10 9 GeV−1 for a measurement time of 30 days. Future upgrades, including pressure tuning of the effective refractive index and implementation of a Fabry–Pérot cavity, could extend the accessible mass range and improve sensitivity, establishing WISPFI as a scalable platform to explore previously inaccessible regions of the axion parameter space. Full article
(This article belongs to the Proceedings of The 19th Patras Workshop on Axions, WIMPs and WISPs)
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16 pages, 1771 KB  
Article
An Investigation of the Modulating Effects of Sensory Stimulation and Transcranial Magnetic Stimulation on Memory-Related Brain Activity
by Stevan Nikolin, Matthew Wang, Adriano Moffa, Haijing Huang, Mei Xu, Siddhartha Raj Pande and Donel Martin
Brain Sci. 2025, 15(11), 1182; https://doi.org/10.3390/brainsci15111182 - 31 Oct 2025
Viewed by 918
Abstract
Background/Objectives: As the global population ages, the prevalence of disorders associated with memory dysfunction (e.g., Alzheimer’s disease) continues to increase. There is a need for novel interventions that can enhance memory and support affected individuals. Non-invasive brain stimulation provides a promising approach [...] Read more.
Background/Objectives: As the global population ages, the prevalence of disorders associated with memory dysfunction (e.g., Alzheimer’s disease) continues to increase. There is a need for novel interventions that can enhance memory and support affected individuals. Non-invasive brain stimulation provides a promising approach to engage circuits within the hippocampal network, a group of brain regions critical for episodic memory, and thereby improve cognition. Methods: Twenty healthy participants completed a single-blind, within-subject crossover study over four sessions. In each session, they received one of four interventions whilst viewing pictures of real-world objects: 40 Hz synchronised audiovisual stimulation (AVS), theta burst stimulation (TBS), a combination of synchronised 5 Hz repetitive transcranial magnetic stimulation with AVS (rTMS + AVS), or sham rTMS. Electroencephalography (EEG) was recorded to measure associated brain activity changes. Following each intervention, participants completed a recognition memory task. Results: Mixed-effect repeated measure models (MRMMs) revealed no significant differences in recognition memory performance or theta (5 Hz) activity across conditions. However, both TBS and rTMS + AVS significantly increased gamma (40 Hz) activity compared to sham rTMS, and TBS induced a widespread increase in theta-gamma phase-amplitude coupling during picture viewing. Conclusions: While the neuromodulatory interventions did not enhance memory performance, the observed increase in gamma activity, particularly following rTMS-based stimulation, suggests potential engagement of neural processes associated with memory. These findings warrant further investigation into the role of gamma oscillations in memory and cognitive enhancement. Full article
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32 pages, 9776 KB  
Article
Application of Comprehensive Geophysical Methods in the Exploration of Fire Area No. 1 in the Miaoergou Coal Field, Xinjiang
by Xinzhong Zhan, Haiyan Yang, Bowen Zhang, Jinlong Liu, Yingying Zhang and Fuhao Li
Appl. Sci. 2025, 15(20), 11164; https://doi.org/10.3390/app152011164 - 17 Oct 2025
Viewed by 585
Abstract
Coal spontaneous combustion in arid regions poses severe threats to both ecological security and resource sustainability. Focusing on the detection challenges in Fire Zone No. 1 of the Miaoergou Coalfield, Xinjiang, this study proposes an Integrated Geophysical Collaborative Detection Framework that combines high-precision [...] Read more.
Coal spontaneous combustion in arid regions poses severe threats to both ecological security and resource sustainability. Focusing on the detection challenges in Fire Zone No. 1 of the Miaoergou Coalfield, Xinjiang, this study proposes an Integrated Geophysical Collaborative Detection Framework that combines high-precision magnetic surveys, spontaneous potential (SP) measurements, and transient electromagnetic (TEM) methods. This innovative framework effectively overcomes the limitations of traditional single-method detection approaches, enabling the precise delineation of fire zone boundaries and the accurate characterization of spatial dynamics of coal fires. The key findings of the study are as follows: (1) High-magnetic anomalies (with a maximum ΔT of 1886.3 nT) exhibit a strong correlation with magnetite-enriched burnt rocks and dense fracture networks (density > 15 fractures/m), with a correlation coefficient (R2) of 0.89; (2) Negative SP anomalies (with a minimum SP of −38.17 mV) can effectively reflect redox interfaces and water-saturated zones (moisture content > 18%), forming a “positive–negative–positive” annular spatial structure where the boundary gradient exceeds 3 mV/m; (3) TEM measurements identify high-resistivity anomalies (resistivity ρ = 260–320 Ω·m), which correspond to non-waterlogged goaf collapse areas. Spatial integration analysis of the three sets of geophysical data shows an anomaly overlap rate of over 85%, and this result is further validated by borehole data with an error margin of less than 10%. This study demonstrates that multi-parameter geophysical coupling can effectively characterize the thermo-hydro-chemical processes associated with coal fires, thereby providing critical technical support for the accurate identification of fire boundaries and the implementation of disaster mitigation measures in arid regions. Full article
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32 pages, 10740 KB  
Article
Hydraulic Electromechanical Regenerative Damper in Vehicle–Track Dynamics: Power Regeneration and Wheel Wear for High-Speed Train
by Zifei He, Ruichen Wang, Zhonghui Yin, Tengchi Sun and Haotian Lyu
Lubricants 2025, 13(9), 424; https://doi.org/10.3390/lubricants13090424 - 22 Sep 2025
Viewed by 859
Abstract
A physics-based vehicle–track coupled dynamic model embedding a hydraulic electromechanical regenerative damper (HERD) is developed to quantify electrical power recovery and wear depth in high-speed service. The HERD subsystem resolves compressible hydraulics, hydraulic rectification, line losses, a hydraulic motor with a permanent-magnet generator, [...] Read more.
A physics-based vehicle–track coupled dynamic model embedding a hydraulic electromechanical regenerative damper (HERD) is developed to quantify electrical power recovery and wear depth in high-speed service. The HERD subsystem resolves compressible hydraulics, hydraulic rectification, line losses, a hydraulic motor with a permanent-magnet generator, an accumulator, and a controllable; co-simulation links SIMPACK with MATLAB/Simulink. Wheel–rail contact is computed with Hertz theory and FASTSIM, and wear depth is advanced with the Archard law using a pressure–velocity coefficient map. Both HERD power regeneration and wear depth predictions have been validated against independent measurements of regenerated power and wear degradation in previous studies. Parametric studies over speed, curve radius, mileage and braking show that increasing speed raises input and output power while recovery efficiency remains 49–50%, with instantaneous electrical peaks up to 425 W and weak sensitivity to curvature and mileage. Under braking from 350 to 150 km/h, force transients are bounded and do not change the lateral wear pattern. Installing HERD lowers peak wear in the wheel tread region; combining HERD with flexible wheelsets further reduces wear depth and slows down degradation relative to rigid wheelsets and matches measured wear more closely. The HERD electrical load provides a physically grounded tuning parameter that sets hydraulic back pressure and effective damping, which improves model accuracy and supports calibration and updating of digital twins for maintenance planning. Full article
(This article belongs to the Special Issue Tribological Challenges in Wheel-Rail Contact)
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21 pages, 3104 KB  
Article
Advanced Structural Assessment of a Bucked-and-Wedged Configuration for the EU DEMO Tokamak Under a 16.5 T Magnetic Field
by Andrea Chiappa and Corrado Groth
Energies 2025, 18(18), 5013; https://doi.org/10.3390/en18185013 - 21 Sep 2025
Viewed by 554
Abstract
The pursuit of compact and efficient fusion energy systems necessitates innovative structural concepts capable of withstanding extreme operational conditions. This study presents a preliminary structural evaluation and stress assessment of a bucked-and-wedged configuration for the EU DEMO tokamak, targeting a peak magnetic field [...] Read more.
The pursuit of compact and efficient fusion energy systems necessitates innovative structural concepts capable of withstanding extreme operational conditions. This study presents a preliminary structural evaluation and stress assessment of a bucked-and-wedged configuration for the EU DEMO tokamak, targeting a peak magnetic field of 16.5 T. The proposed concept leverages mutual wedging of the Toroidal Field (TF) coils and their interaction with the Central Solenoid (CS) to optimize stress distribution in the inner legs, a critical region in high-field fusion reactors. To address the significant tangential forces arising during plasma operation, the design integrates outer inter-coil structures and shear pins to enhance mechanical stability. A hybrid simulation approach—coupling 3D electromagnetic and structural finite element analyses—is employed to assess stress behavior and structural integrity under both in-plane and out-of-plane loading conditions. The results contribute to the optimization study of high-field fusion reactor components and offer insights into viable mechanical design strategies for next-generation nuclear energy systems. Full article
(This article belongs to the Special Issue Advanced Simulations for Nuclear Fusion Energy Systems)
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17 pages, 3464 KB  
Article
Advanced Spectroscopic and Thermoanalytical Quantification of LLDPE in Mealworm Frass: A Multitechnique Approach
by Encarnación Martínez-Sabater, Rosa Peñalver, Margarita Ros, José A. Pascual, Raul Moral and Frutos C. Marhuenda-Egea
Appl. Sci. 2025, 15(18), 10244; https://doi.org/10.3390/app151810244 - 20 Sep 2025
Viewed by 632
Abstract
Plastic pollution from polyethylene-based materials is a critical environmental concern due to their high persistence. Here, we report the first proof-of-concept application of a multitechnique analytical framework for quantifying linear low-density polyethylene (LLDPE) in Tenebrio molitor frass. Artificially enriched frass–LLDPE mixtures were analyzed [...] Read more.
Plastic pollution from polyethylene-based materials is a critical environmental concern due to their high persistence. Here, we report the first proof-of-concept application of a multitechnique analytical framework for quantifying linear low-density polyethylene (LLDPE) in Tenebrio molitor frass. Artificially enriched frass–LLDPE mixtures were analyzed using thermogravimetric analysis (TGA), TGA coupled with Fourier-Transform Infrared Spectroscopy (FTIR) and Mass Spectrometry (MS), TGA under inert atmosphere, and solid-state 13C nuclear magnetic resonance spectroscopy with Cross-Polarization and Magic Angle Spinning (CP-MAS NMR) 13C CP-MAS NMR combined with interval Partial Least Squares (iPLS) modeling. Thermal methods provided insight into decomposition pathways but showed reduced specificity at <1% w/w due to matrix interference. CP-MAS NMR offered matrix-independent quantification, with characteristic signals in the 10–45 ppm region and a calculated LOD and LOQ of 0.173% and 0.525% w/w, respectively. The LOQ lies within the reported ingestion range for T. molitor (0.8–3.2% w/w in frass), confirming biological relevance. This validated workflow establishes CP-MAS NMR as the most robust tool for quantifying polyethylene residues in complex matrices and provides a foundation for in vivo biodegradation studies and environmental monitoring. Full article
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29 pages, 23339 KB  
Article
Pullout Behaviour and Influencing Mechanisms of Desert Plant Roots in Clayey Sand During Thawing
by Xiaofei Yang, Qinglin Li, Shuailong Yu, Pengrui Feng, Meixue Zhang, Wenjuan Chen and Guang Yang
Plants 2025, 14(18), 2876; https://doi.org/10.3390/plants14182876 - 16 Sep 2025
Viewed by 819
Abstract
In cold and arid regions, the mechanical properties and influencing mechanisms of the root–soil interface during the thawing stage remain poorly understood. This study focuses on Alhagi sparsifolia root–clayey sand composites to investigate the effects of temperature (−10 °C to 25 °C), initial [...] Read more.
In cold and arid regions, the mechanical properties and influencing mechanisms of the root–soil interface during the thawing stage remain poorly understood. This study focuses on Alhagi sparsifolia root–clayey sand composites to investigate the effects of temperature (−10 °C to 25 °C), initial soil water content (4–12%), and naturally varying root diameter (4.50–5.05 mm) on root pullout behaviour, and integrates endoscopic macro-observation, environmental scanning electron microscopy (ESEM), soil water migration tests, and nuclear magnetic resonance (NMR) techniques to reveal the dominant influencing mechanisms. Key findings reveal the following: (1) An increase in soil water content from 4% to 12%, and a temperature rise from −10 °C to 25 °C led to a maximum reduction in the average peak pullout force (FT) of roots exceeding 95%. (2) There is a non-monotonic relationship between root diameter and pull-out force, which can be attributed to two distinct failure modes: a newly observed failure mode known as root bark peeling, occurring under high soil moisture conditions (≥8%), and a commonly observed failure mode referred to as partial soil detachment, occurring under low soil moisture conditions (≤6%). (3) The coupling effects of temperature and water content reveal that the increase in temperature predominantly contributes to strength loss (>63%) during the ice–water phase transition (−10 °C to 0 °C), while soil water content primarily influences root pullout behaviour in the liquid water stage (5 °C to 25 °C). (4) As the temperature rises, in soils with low water content (4–6%), the reinforcing effect of roots appears to stabilize at −1 °C, whereas in soils with high water content (8–12%), stabilization occurs only beyond 5 °C. These findings enhance the understanding of root–soil interactions in thawing environments and provide a theoretical basis for soil bioengineering techniques aimed at slope stabilization in cold and arid regions. Full article
(This article belongs to the Section Plant Response to Abiotic Stress and Climate Change)
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12 pages, 2470 KB  
Article
A Preliminary Study on the Accuracy of MRI-Guided Thalamic Infusion of AAV2-GFP and Biodistribution Analysis Using Cryo-Fluorescence Tomography in Nonhuman Primates
by Ernesto A. Salegio, Reinier Espinosa, Geary R. Smith, David Shoshan, Matthew Silva, Eli White and Jacob McDonald
Pharmaceutics 2025, 17(9), 1167; https://doi.org/10.3390/pharmaceutics17091167 - 6 Sep 2025
Viewed by 982
Abstract
Background: Adeno-associated viral (AAV) vectors are the leading platform for gene therapy, but common delivery routes show limited spread to distal cortical structures, hence the utility of direct, intrathalamic infusions for broader transgene distribution. In this preliminary study, we recapitulate previous studies targeting [...] Read more.
Background: Adeno-associated viral (AAV) vectors are the leading platform for gene therapy, but common delivery routes show limited spread to distal cortical structures, hence the utility of direct, intrathalamic infusions for broader transgene distribution. In this preliminary study, we recapitulate previous studies targeting the thalamus as a conduit to achieve cortical transgene spread and showcase novel data evaluating biodistribution of a green fluorescent protein (GFP) using cryo-fluorescence tomography (CFT). For the first time in nonhuman primates (NHPs) and coupled with magnetic resonance imaging (MRI)-guidance, we demonstrated the application of CFT as a powerful tool to map out vector distribution in the NHP brain. Methods: Briefly, a single thalamic infusion was performed in African green monkeys using ClearPoint’s navigational platform to deliver an AAV serotype 2 vector containing a GFP payload. Transgene biodistribution was assessed in the left and right hemispheres using CFT and histological analysis, respectively. Results: Infusions were successfully performed with sub-millimetric target accuracy and with minimal error, achieving ~86% thalamic coverage with the largest infusion volume. Histology confirmed the presence of the GFP transgene, with the strongest signal in the cerebral gray/white matter and internal capsule, while CFT allowed for the three-dimensional detection of the transgene starting at the site of infusion and spreading to multiple cortical regions. Conclusions: These findings suggest that by combining MRI-guided technology with CFT imaging, it is feasible to map whole-brain gene biodistribution in NHPs. This proof-of-concept study bridges the gap between cellular microscopy and MRI-guidance to provide a complete picture of disease and treatment with clinical applicability. Full article
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18 pages, 6449 KB  
Article
Analysis of the Microscopic Pore Structure Characteristics of Sandstone Based on Nuclear Magnetic Resonance Experiments and Nuclear Magnetic Resonance Logging Technology
by Shiqin Li, Chuanqi Tao, Haiyang Fu, Huan Miao and Jiutong Qiu
Fractal Fract. 2025, 9(8), 532; https://doi.org/10.3390/fractalfract9080532 - 14 Aug 2025
Cited by 2 | Viewed by 992
Abstract
This study focuses on the complex pore structure and pronounced heterogeneity of tight sandstone reservoirs in the Linxing area of the Ordos Basin and develops a multi-scale quantitative characterization approach to investigate the coupling mechanism between pore structure and reservoir properties. Six core [...] Read more.
This study focuses on the complex pore structure and pronounced heterogeneity of tight sandstone reservoirs in the Linxing area of the Ordos Basin and develops a multi-scale quantitative characterization approach to investigate the coupling mechanism between pore structure and reservoir properties. Six core samples were selected from the Shiqianfeng Formation (depth interval: 1326–1421 m) for detailed analysis. Cast thin sections and scanning electron microscopy (SEM) experiments were employed to characterize pore types and structural features. Nuclear magnetic resonance (NMR) experiments were conducted to obtain T2 spectra, which were used to classify bound and movable pores, and their corresponding fractal dimensions were calculated separately. In addition, NMR logging data from the corresponding well intervals were integrated to assess the applicability and consistency of the fractal characteristics at the logging scale. The results reveal that the fractal dimension of bound pores shows a positive correlation with porosity, whereas that of movable pores is negatively correlated with permeability, indicating that different scales of pore structural complexity exert distinct influences on reservoir performance. Mineral composition affects the evolution of pore structures through mechanisms such as framework support, dissolution, and pore-filling, thereby further enhancing reservoir heterogeneity. The consistency between logging responses and experimental observations verifies the regional applicability of fractal analysis. Bound pores dominate within the studied interval, and the vertical variation of the PMF/BVI ratio aligns closely with both the NMR T2 spectra and fractal results. This study demonstrates that fractal dimension is an effective descriptor of structural characteristics across different pore types and provides a theoretical foundation and methodological support for the evaluation of pore complexity and heterogeneity in tight sandstone reservoirs. Full article
(This article belongs to the Special Issue Multiscale Fractal Analysis in Unconventional Reservoirs)
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24 pages, 6356 KB  
Article
Tectonic Rift-Related Manganese Mineralization System and Its Geophysical Signature in the Nanpanjiang Basin
by Daman Cui, Zhifang Zhao, Wenlong Liu, Haiying Yang, Yun Liu, Jianliang Liu and Baowen Shi
Remote Sens. 2025, 17(15), 2702; https://doi.org/10.3390/rs17152702 - 4 Aug 2025
Viewed by 1116
Abstract
The southeastern Yunnan region in the southwestern Nanpanjiang Basin is one of the most important manganese enrichment zones in China. Manganese mineralization is mainly confined to marine mud–sand–carbonate interbeds of the Middle Triassic Ladinian Falang Formation (T2f), which contains several [...] Read more.
The southeastern Yunnan region in the southwestern Nanpanjiang Basin is one of the most important manganese enrichment zones in China. Manganese mineralization is mainly confined to marine mud–sand–carbonate interbeds of the Middle Triassic Ladinian Falang Formation (T2f), which contains several medium to large deposits such as Dounan, Baixian, and Yanzijiao. However, the geological processes that control manganese mineralization in this region remain insufficiently understood. Understanding the tectonic evolution of the basin is therefore essential to unravel the mechanisms of Middle Triassic metallogenesis. This study investigates how rift-related tectonic activity influences manganese ore formation. This study integrates global gravity and magnetic field models (WGM2012, EMAG2v3), audio-frequency magnetotelluric (AMT) profiles, and regional geological data to investigate ore-controlling structures. A distinct gravity low–magnetic high belt is delineated along the basin axis, indicating lithospheric thinning and enhanced mantle-derived heat flow. Structural interpretation reveals a rift system with a checkerboard pattern formed by intersecting NE-trending major faults and NW-trending secondary faults. Four hydrothermal plume centers are identified at these fault intersections. AMT profiles show that manganese ore bodies correspond to stable low-resistivity zones, suggesting fluid-rich, hydrothermally altered horizons. These findings demonstrate a strong spatial coupling between hydrothermal activity and mineralization. This study provides the first identification of the internal rift architecture within the Nanpanjiang Basin. The basin-scale rift–graben system exerts first-order control on sedimentation and manganese metallogenesis, supporting a trinity model of tectonic control, hydrothermal fluid transport, and sedimentary enrichment. These insights not only improve our understanding of rift-related manganese formation in southeastern Yunnan but also offer a methodological framework applicable to similar rift basins worldwide. Full article
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