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Pharmaceutics
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New Trends in the Controlled Release Systems of Medicinal Substances...
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New Trends in the Controlled Release Systems of Medicinal Substances Used in the Treatment of Diseases of the Central Nervous System

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 12632

Special Issue Editors

Dr. Artur Turek

E-Mail Website
Guest Editor
Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 41-200 Katowice, Poland
Interests: biomaterials; biomedical engineering; drug technology; surface sciences
Special Issues, Collections and Topics in MDPI journals
Dr. Zhenjia Wang

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA
Interests: drug delivery; cell-based therapy; intravital microscopy; inflammatory diseases and cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to advances in innovative drug delivery systems used in the treatment of central nervous system diseases, i.e., schizophrenia, bipolar affective disorder, depression, dementia, neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease, and brain tumors with special attention to glioblastoma multiforme.

The SI targets the aspect of the delivery of medicinal substances, administration of medicinal products, permeation through the blood–brain barrier, ensuring therapeutic concentration, and the formulation process.

The topics of interest include the following areas:

  • Design and formulation methods of drug delivery systems to brain tissue administration;
  • The mechanisms of drug delivery, drug release patterns, and in vitro–in vivo correlation;
  • Nanoscale brain-targeting drug delivery strategies overcoming the blood–brain barrier;
  • Intracranial drug delivery systems as an independent therapeutic procedure or supporting surgical methods;
  • Current state orally disintegrating tablets used in neurodegenerative diseases;
  • The role of multiple-coated and multi-content formulations in therapy optimization.

I hope that this Special Issue will provide a roadmap for all scientists and practitioners in the treatment of central nervous system diseases.

Dr. Artur Turek
Dr. Zhenjia Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • brain-targeting drug delivery
  • central nervous system
  • schizophrenia
  • depression
  • Parkinson’s disease
  • Alzheimer’s disease
  • glioblastoma multiforme

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Published Papers (3 papers)

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Research

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12 pages, 2970 KiB  
Article
Radiolabeled Risperidone microSPECT/CT Imaging for Intranasal Implant Studies Development
by Jon Ander Simón, Emilia Utomo, Félix Pareja, María Collantes, Gemma Quincoces, Aarón Otero, Margarita Ecay, Juan Domínguez-Robles, Eneko Larrañeta and Iván Peñuelas
Pharmaceutics 2023, 15(3), 843; https://doi.org/10.3390/pharmaceutics15030843 - 4 Mar 2023
Cited by 5 | Viewed by 1907
Abstract
The use of intranasal implantable drug delivery systems has many potential advantages for the treatment of different diseases, as they can provide sustained drug delivery, improving patient compliance. We describe a novel proof-of-concept methodological study using intranasal implants with radiolabeled risperidone (RISP) as [...] Read more.
The use of intranasal implantable drug delivery systems has many potential advantages for the treatment of different diseases, as they can provide sustained drug delivery, improving patient compliance. We describe a novel proof-of-concept methodological study using intranasal implants with radiolabeled risperidone (RISP) as a model molecule. This novel approach could provide very valuable data for the design and optimization of intranasal implants for sustained drug delivery. RISP was radiolabeled with 125I by solid supported direct halogen electrophilic substitution and added to a poly(lactide-co-glycolide) (PLGA; 75/25 D,L-Lactide/glycolide ratio) solution that was casted on top of 3D-printed silicone molds adapted for intranasal administration to laboratory animals. Implants were intranasally administered to rats, and radiolabeled RISP release followed for 4 weeks by in vivo non-invasive quantitative microSPECT/CT imaging. Percentage release data were compared with in vitro ones using radiolabeled implants containing either 125I-RISP or [125I]INa and also by HPLC measurement of drug release. Implants remained in the nasal cavity for up to a month and were slowly and steadily dissolved. All methods showed a fast release of the lipophilic drug in the first days with a steadier increase to reach a plateau after approximately 5 days. The release of [125I]I− took place at a much slower rate. We herein demonstrate the feasibility of this experimental approach to obtain high-resolution, non-invasive quantitative images of the release of the radiolabeled drug, providing valuable information for improved pharmaceutical development of intranasal implants. Full article
(This article belongs to the Special Issue New Trends in the Controlled Release Systems of Medicinal Substances Used in the Treatment of Diseases of the Central Nervous System)
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Review

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31 pages, 1149 KiB  
Review
Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution
by Magdalena Markowicz-Piasecka, Marcin Kubisiak, Katarzyna Asendrych-Wicik, Michał Kołodziejczyk, Joanna Grzelińska, Małgorzata Fabijańska and Tomasz Pietrzak
Pharmaceutics 2024, 16(1), 28; https://doi.org/10.3390/pharmaceutics16010028 - 24 Dec 2023
Cited by 3 | Viewed by 6171
Abstract
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness. These injectable pharmaceuticals help patients manage their condition better and improve long-term outcomes by preventing relapses and improving compliance. This review aims to analyse the current formulation [...] Read more.
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for individuals suffering from persistent mental illness. These injectable pharmaceuticals help patients manage their condition better and improve long-term outcomes by preventing relapses and improving compliance. This review aims to analyse the current formulation aspects of LAI neuroleptics, with particular emphasis on analysis of drug release profiles as a critical test to guarantee drug quality and relevant therapeutical activity. While there is no officially approved procedure for depot parenteral drug formulations, various dissolution tests which were developed by LAI manufacturers are described. In vitro dissolution tests also possess a critical function in the estimation of the in vivo performance of a drug formulation. For that reason, thorough inspection of the in vitro–in vivo correlation (IVIVC) is also discussed. Full article
(This article belongs to the Special Issue New Trends in the Controlled Release Systems of Medicinal Substances Used in the Treatment of Diseases of the Central Nervous System)
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23 pages, 2617 KiB  
Review
Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases
by Ilona Nowak, Marcel Madej, Julia Secemska, Robert Sarna and Barbara Strzalka-Mrozik
Pharmaceutics 2023, 15(7), 1931; https://doi.org/10.3390/pharmaceutics15071931 - 11 Jul 2023
Cited by 7 | Viewed by 2726
Abstract
Central nervous system (CNS) diseases are currently a major challenge in medicine. One reason is the presence of the blood–brain barrier, which is a significant limitation for currently used medicinal substances that are characterized by a high molecular weight and a short half-life. [...] Read more.
Central nervous system (CNS) diseases are currently a major challenge in medicine. One reason is the presence of the blood–brain barrier, which is a significant limitation for currently used medicinal substances that are characterized by a high molecular weight and a short half-life. Despite the application of nanotechnology, there is still the problem of targeting and the occurrence of systemic toxicity. Viral vectors and virus-like particles (VLPs) may provide a promising solution to these challenges. Their small size, biocompatibility, ability to carry medicinal substances, and specific targeting of neural cells make them useful in research when formulating a new generation of biological carriers. Additionally, the possibility of genetic modification has the potential for gene therapy. Among the most promising viral vectors are adeno-associated viruses, adenoviruses, and retroviruses. This is due to their natural tropism to neural cells, as well as the possibility of genetic and surface modification. Moreover, VLPs that are devoid of infectious genetic material in favor of increasing capacity are also leading the way for research on new drug delivery systems. The aim of this study is to review the most recent reports on the use of viral vectors and VLPs in the treatment of selected CNS diseases. Full article
(This article belongs to the Special Issue New Trends in the Controlled Release Systems of Medicinal Substances Used in the Treatment of Diseases of the Central Nervous System)
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