Search Results (202)

We report a novel approach to fabricating high-performance and robust quantum dot light-emitting diodes (QLEDs) utilizing sputtered SnO₂ thin films as the electron transport layer (ETL). While conventional solution-processed ZnMgO NP ETLs face limitations in mass production, the sputtering process offers advantages for uniform and reproducible thin film deposition. Herein, the structural, optical, and electrical properties of SnO₂ thin films were optimized by controlling the Ar/O₂ ratio and substrate heating temperature during sputtering. SnO₂ thin films with O₂ gas improve charge balancing in QLEDs by lowering the conduction band minimum. Furthermore, it was observed that oxygen vacancies in SnO₂ function as exciton quenching sites, which directly impacts the long-term stability of the device. QLEDs fabricated under optimal conditions (Ar/O₂ = 35:5, 200 °C heating) achieved a peak luminance of 99,212 cd/m² and a current efficiency of 21.17 cd/A with excellent device stability. The findings suggest that sputtered SnO₂ ETLs are a highly promising technology for the commercial production of QLEDs. Full article

We aimed to develop and internally validate a nomogram to estimate axillary pathological complete response (pCR, ypN0) after neoadjuvant systemic therapy (NAST) in clinically node-positive (cN1–2) breast cancer. In a single-center retrospective cohort of 144 consecutive patients treated with NAST (anti-HER2 as indicated), all underwent standardized pre- and post-NAST 18F-FDG PET/CT and axillary staging (sentinel lymph node biopsy [SLNB], targeted axillary dissection [TAD], or axillary lymph node dissection [ALND]). Axillary pCR occurred in 51.4% (74/144). In a multivariable analysis, independent positive determinants of ypN0 included the triple-negative subtype, Modified PERCIST (SUVmax-based) reduction ≥ 80.70%, pre-NAST tumor-to-axilla SUVmax ratio ≥ 1.21, and residual breast tumor size < 0.5 mm; conversely, conglomerate/matted nodal morphology at diagnosis was inversely associated. The model showed good internal discrimination (AUC 0.857, 95% CI 0.797–0.917) and acceptable calibration (Hosmer–Lemeshow p = 0.425). Exploratory, subtype-restricted signals were observed for inflammatory indices within Luminal B (HER2+) but were not retained in the final model. The resulting nomogram—combining tumor biology, PET/CT response, and pre-NAST nodal features—may support risk stratification for axillary de-escalation after NAST; however, prospective external validation—ideally embedded in ongoing de-escalation frameworks—remains essential before clinical implementation, and the tool should currently be regarded as hypothesis-generating rather than a stand-alone decision aid for routine practice. Full article

We develop predictive models for OH maser occurrence in Galactic star-forming regions by integrating dense-clump physical properties from the APEX Telescope Large Area Survey of the Galaxy (ATLASGAL) and Herschel Infrared Galactic Plane Survey (Hi-GAL) 360° catalogs with maser detections and non-detections compiled in the MaserDB.net database. We compare two predictive modeling approaches for Galactic OH maser incidence: a Generalized Linear Model (GLM; logistic regression) and a compact Keras-based binary neural network (BNN). For the 1665/1667 MHz lines, both models achieve recall of 90% with a precision of approximately 50%, while for the excited-state 6031/6035 MHz lines, precision reaches roughly 20% at the same recall. We found no statistically significant difference between the BNN and GLM in out-of-sample performance. This implies that maser occurrence may be expressed as a monotonic trend without requiring nonlinear interactions. Across different catalogs and transition lines, luminosity, luminosity-to-mass ratio ($L/M$), dust temperature, and ${\mathrm{H}}_2$ column, surface, and volume densities are the most influential features for maser prediction. These variables support a physical picture in which radiative pumping favors warm, luminous, and compact clump environments. We provide an accessible online tool that allows users to predict the likelihood of OH maser emission toward ATLASGAL or Hi-GAL sources based on coordinate lists. Full article

Formamidinium lead bromide (FAPbBr₃) quantum dots (QDs) have shown potential in light-emitting diodes (LEDs). However, their performance is constrained by surface defects and the limitations of charge transport. Zwitterionic ligands, owing to their twin functions of Lewis base coordination and electrostatic compensation, passivate surface defects of perovskite QDs. Some other zwitterionic ligands are high-cost, while amino acids, as zwitterionic ligands, are inexpensive, readily available, and have efficient passivation capabilities. Their short main chain and programmable side chain can control the volume and dipole at Å-scale range through functional group selection and feed ratio regulation, achieving interface energy level engineering. This work adopts green-emitting FAPbBr₃ QDs as the model, tuning ligand properties by modifying side-chain functional groups, thereby achieving PLQY of 87.2%. Experimental results and DFT reveal that amino acids preferentially undergo coordination and can be further fine-tuned through conjugated contacts. Without severe site competition and without affecting coordination occupation and ligand uniformity, the EQE reaches 5.6% and the luminance exceeds 9000 cd/m². This low-cost technology is easily scalable and broadly manufacturable, providing a replicable material and interface design route for green zone perovskite LEDs. Full article

Nucleic acid aptamers leverage defined tertiary structures for precise molecular recognition, positioning them as transformative biomedical tools. We engineered AP1-F, a G-quadruplex (G4)-structured aptamer that selectively binds membrane-anchored nucleolin (NCL) non-permeabilizing, overcoming a key limitation of conventional probes. Microscale thermophoresis confirmed nanomolar affinity to NCL. By means of rigorous optimization, AP1-F attained a greater than ten-fold fluorescence signal ratio between malignant and normal cells in co-cultures, exceeding the extensively researched AS1411. Dual-channel flow cytometry demonstrated over 98.78% specificity at single-cell resolution within heterogeneous cell populations, owing to AP1-F’s unique membrane localization—unlike AS1411’s intracellular uptake, which elicited erroneous signals from cytoplasmic NCL. Competitive binding experiments and Laser Confocal Imaging confirmed that AP1-F specifically identifies cancer cells by binding to the NCL recognition site on the membrane. In pathological sections, AP1-F exhibited a 40.5-fold fluorescence intensity ratio between tumor and normal tissue, facilitating accurate tissue-level differentiation. Significantly, it delineated molecular subtypes by associating membrane NCL patterns with morphometric analysis: luminal-like MCF-7 displayed consistent staining in cohesive clusters, whereas basal-like MDA-MB-468 revealed sporadic NCL with irregular outlines—characteristics imperceptible to intracellular-targeted antibodies, thus offering subtype-specific diagnostic insights. This combination biochemical–morphological approach accomplished subtype differentiation with a single-step, non-permeabilized process that maintained lower cytotoxicity and tissue integrity. AP1-F enhances diagnostic accuracy by utilizing spatial confinement to eradicate intracellular interference, connecting molecular specificity to intraoperative margin evaluation or biopsy categorization. Full article

Objectives: This paper aims to explore optical coherence tomography (OCT)-based choroidal vascular changes in patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) agents, faricimab and ranibizumab, in a pilot study. Methods: This retrospective pilot cohort study enrolled 28 treatment-naïve nAMD patients who received three consecutive intravitreal anti-VEGF injections at Nara Medical University Hospital. In total, 17 patients (61%) were Type 1 MNV and 11 patients (39%) were Type 2 MNV. Patients were divided into a faricimab group (13 eyes) and a ranibizumab group (15 eyes). The type of macular neovascularization (MNV) and the presence of polyps were recorded. The central choroidal thickness (CCT) and the ratio of luminal area to choroidal area (L/C ratio), derived from binarized OCT images, were measured at baseline after the first and third injections. Results: Type 1 MNV was observed in 61% of eyes, with polyps confirmed in 53%. There was no significant difference in best corrected visual acuity (BCVA) for both faricimab and ranibizumab during treatment (p = 0.12, 0.94, respectively). After the third injection, a dry macula was achieved in 62% of the faricimab group and 60% of the ranibizumab group. In the ranibizumab group, CCT significantly decreased after the first injection, while no significant change was observed in the faricimab group. Conversely, the L/C ratio significantly decreased in the faricimab group after the third injection (p = 0.010). Among faricimab-treated eyes, those with type 1 MNV showed a significantly greater reduction in the L/C ratio compared to type 2 MNV (p = 0.017). Conclusions: This pilot study suggests that faricimab may exert combined anti-VEGF and Ang-2 effects predominantly on type 1 MNV, potentially leading to vascular constriction. These exploratory findings warrant confirmation in larger studies. Full article

This paper presents a multiscale histogram excess-distribution strategy addressing the structural limitations (i.e., insufficient dark-region restoration, block artifacts, ringing effects, color distortion, and saturation loss) of contrast-limited adaptive histogram equalization (CLAHE) and retinex-based image-contrast enhancement techniques. This method adjusts the ratio between the uniform and weighted distribution of the histogram excess based on the average tile brightness. At the coarsest scale, excess pixels are redistributed to histogram bins initially occupied by pixels, maximizing detail restoration in dark areas. For medium and fine scales, the contrast enhancement strength is adjusted according to tile brightness to preserve local luminance transitions. Scale-specific lookup tables are bilinearly interpolated and merged at the pixel level. Background restoration corrects unnatural tone compression by referencing the original image, ensuring visual consistency. A ratio-based chroma adjustment and color-restoration function compensate for saturation degradation in retinex-based approaches. An asymmetric Gaussian offset correction preserves structural information and expands the global dynamic range. The experimental results demonstrate that this method enhances local and global contrast while preserving fine details in low light and high brightness. Compared with various existing methods, this method reproduces more natural color with superior image enhancement. Full article

Nitrogen metabolism in the human body is in a strictly balanced state, which is disturbed in pathologies, including breast cancer. The state of nitrogen balance can be judged by the content of urea and the amount of branched-chain amino acids (BCAAs) (Val, Leu, and Ile), glutamine (Gln), and glutamate (Glu). The study involved 1438 people, including patients with breast cancer (n = 543), fibroadenomas (n = 597), and healthy controls (n = 298). Saliva samples were collected from all patients before treatment, and urea levels were determined in all 1438 samples. Salivary levels of BCAAs, Gln, and Glu were determined in 116 patients with breast cancer, 24 with fibroadenomas, and 25 healthy volunteers. An increase in the concentration of urea in saliva was shown in breast cancer, most pronounced in luminal molecular biological subtypes: luminal A 10.46 [7.69; 12.62] mmol/L (p < 0.0001), luminal B HER2-negative 9.52 [6.72; 12.52] mmol/L (p = 0.0198), and luminal B HER2-positive 8.26 [5.27; 12.07] mmol/L. The Gln/Glu ratio increased in the saliva of the control group (5.43 [3.30; 10.5]) compared with breast cancer (2.22 [0.84; 5.40], p = 0.0094) and fibroadenomas (1.94 [0.89; 6.05], p = 0.0184). For luminal B HER2-positive and TNBC, the Gln/Glu ratio increased sharply to 8.23 [3.24; 10.9] (p = 0.0327) and 11.2 [4.28; 15.2] (p < 0.0001) compared with healthy controls. Thus, an increased Gln/Glu ratio in saliva may characterize a more aggressive subtype of breast cancer. Full article

Increasing the lighting luminance in the diverging zone of interchange in highway tunnels can generally enhance driving safety. However, it creates a bright–dark luminance contrast with the adjacent road. A pronounced contrast can induce new driving risks. This underlying mechanism remains unclear. Three key factors, i.e., the luminance of the dark environment, the bright–dark luminance ratio, and the position of the small target, are identified in this paper, which affect drivers’ visual recognition abilities. Based on fundamental tunnel lighting design rules, a series of naturalistic driving tests on the visual recognition distance for small targets with 132 conditions were designed. It combined three dark environment luminance levels (1.5~3.5 cd/m²), four bright–dark luminance ratios (2~5), and eleven small target positions (−50~+50 m). Twenty-four drivers were randomly selected and drove vehicles under the different scenarios. Their visual recognition distances for small targets were recorded and analyzed. The results show that visual recognition distances for small target visuals under different bright–dark lighting environments vary significantly, and the shortest distances occur exactly at the luminance boundary. Both decreasing the bright–dark luminance ratio and proportionally increasing the luminance levels of the bright and dark environments can markedly improve the visual recognition distance. A multi-parameter regression model was developed to correlate the visual recognition distance at the bright–dark luminance boundary with the luminance of the dark environment and the bright–dark luminance ratio. Based on drivers’ required safe sight distance, a method for setting lighting luminance in the diverging zone of interchange was proposed. The methodology and findings offer technical support for lighting design and safety management in the diverging zone of interchange in highway tunnels. Full article

The visual performance and photobiological effects of white LED systems based on spectral compensation are discussed, specifically focusing on the total optical power, the ratio of scotopic vision luminous flux to photopic vision luminous flux (S/P), the blue light hazard (BLH), and the circadian action factor (CAF). Theoretical models are established by integrating the spectral power distribution (SPD) with spectral sensitivity functions associated with the human visual system, and meanwhile, the impacts of LEDs’ electro-thermal characteristics on the mixed spectral structure and optical properties are analyzed. As experimental results demonstrate, an excellent agreement is shown between the calculated and measured values of the total optical power, S/P, BLH, and CAF, in terms of both values and variation trends. These proposed models are expected to serve as effective tools for understanding the visual perception and non-visual biological effects in specific illumination environments. Moreover, they can offer valuable reference frameworks for the development of lighting solutions that are more human-centered and health-oriented. Full article

Objectives: To investigate the association between the hole border morphology and choroidal structure in idiopathic macular hole (IMH) patients and its impact on visual outcomes. Methods: A retrospective case–control study of 34 IMH eyes and 34 control eyes was conducted. Spectral-domain optical coherence tomography (SD-OCT) was used to categorize the patients into groups with smooth or bumpy hole borders. Based on this classification, a further evaluation was conducted of MH morphology and choroidal structure, both before a vitrectomy and at 1 and 2 months post-surgery. The choriocapillaris, Sattler’s layer, and Haller’s layer were the divisions of each choroidal vascular layer. Then, binarization techniques were employed to calculate the choroidal area (CA), luminal area (LA), stromal area (SA), and central choroidal thickness (CCT). The L/C ratio was established as the ratio of LA to CA. Results: In the patients with IMH, the choroidal structure was associated with the morphology of the hole border. In particular, the eyes with bumpy hole borders were significantly correlated with reduced choroidal thickness and total choroidal area, as well as a reduced L/C ratio in the choriocapillaris. After surgery, visual acuity improved in both groups, but the patients with smooth hole borders achieved earlier and higher levels of visual recovery. The multivariate analysis suggested that a bumpy hole border and the basal hole diameter were independent predictors of postoperative choriocapillaris recovery. Conclusions: Bumpy idiopathic macular hole borders are associated with impaired choroidal vasculatures, particularly in the choriocapillaris, which may be a contributing factor to delayed visual acuity recovery post-surgery. Full article

Vanadium dioxide (VO₂) has become one of the most promising smart temperature-controlled thin-film materials due to its reversible phase transition between a metallic and an insulating state at approximately 68 °C, accompanied by negligible volume change and excellent optical modulation properties. However, the practical application of VO₂ is still limited by its relatively high phase transition temperature and susceptibility to oxidation. To address these two major shortcomings, this study employed a one-step hydrothermal method to prepare a VO₂ nanopowder, followed by a chemical precipitation method to form a VO₂@AlF₃ core–shell structure. The coated nanoparticles were then dispersed in a PVP ethanol solution, coated onto a glass substrate, and evaluated for performance. The experimental results indicate that when the molar ratio of VO₂ to AlF₃ reached 1:1, the phase transition temperature of VO₂@AlF₃ was effectively reduced to 50.3 °C, significantly lower than the original temperature of 68 °C. Additionally, the material exhibited favorable optical properties, with a solar modulation ability (ΔT_sol) of 17.2% and a luminous transmittance (T_lum) of 36.3%. After calcination in air at 300 °C for 3–6 h, the VO₂ core remained oxidation-resistant and maintained excellent phase-change thermal insulation properties. Full article

WWOX and HIF1α proteins are involved in cancer progression; their functions are closely related. WWOX binds HIF1α through its WW domains, sequestering it in the cytoplasm and inhibiting its transcriptional activity. This study evaluates the prognostic significance of the WWOX/HIF1A interaction across cancers, breast cancer subtypes, glioblastoma (GBM), low-grade glioma (LGG), and hepatocellular carcinoma (HCC) through gene expression and pathway analysis focused on metabolism, ECM, and epithelial–mesenchymal transition. In breast cancer, metabolic pathways correlated with good prognosis in basal subtypes. HER2 subtypes showed enrichment in DNA replication pathways. Luminal A subtypes showed favourable prognosis via TNF and PI3K/AKT signalling, while luminal B subtypes had poor prognosis tied to metabolic activity; genes associated with good prognosis mirrored those tied to poor prognosis in luminal A. In HCC, enhanced metabolic activity was associated with good prognosis. In contrast, poor prognosis involved TNF signalling and cytoskeleton-related pathways, indicating more aggressive tumour behaviour. In LGG, good prognosis was linked to metabolic and cAMP pathways, while poor outcomes involved TNF, cell cycle, apoptosis, and focal adhesion pathways. GBM showed similar patterns: metabolic and cAMP pathways indicated better outcomes, while NFKB, TNF, JAK-STAT, and PI3K/AKT pathways marked poor prognosis. These findings suggest the WWOX/HIF1A ratio is a robust prognostic marker and a possible guide for developing targeted treatments. Full article

Urban parks often represent the last viable habitats for wildlife in city centres, functioning as crucial refuges and biodiversity hotspots for a wide array of plant and animal species. This study investigates the issue of light pollution in urban parks in selected Polish cities from the perspective of sustainable urban development and dark-sky friendly ordinances. Field data conducted in 2024 and 2025 include measurements of Upward Light Output Ratio (ULOR), illuminance, luminance, correlated colour temperature (CCT), and spectral characteristics of light sources. In addition, an analysis of changes in the level of light pollution in the studied parks and their surroundings between 2012 and 2025 was performed using data from the VIIRS (Visible Infrared Imaging Radiometer Suite) located on the Suomi NPP satellite. Results highlight the mismatch between sustainable development objectives and the current practice of lighting in most of the analysed parks. The study emphasises the need for better integration of light pollution mitigation in urban spatial policies and provides recommendations for environmentally and socially responsible lighting design in urban parks. Full article

In order to improve image visual quality in high dynamic range (HDR) scenes while avoiding motion ghosting artifacts caused by exposure time differences, innovative image sensors captured two registered extreme-exposure-ratio (EER) image pairs with complementary and symmetric exposure configurations for high dynamic range imaging (HDRI). However, existing multi-exposure fusion (MEF) algorithms suffer from luminance inversion artifacts in overexposed and underexposed regions when directly combining such EER image pairs. This paper proposes a neural network-based framework for HDRI based on attention mechanisms and edge assistance to recover missing luminance information. The framework derives local luminance representations from a convolution kernel perspective, and subsequently refines the global luminance order in the fused image using a Transformer-based residual group. To support the two-stage process, multi-scale channel features are extracted from a double-attention mechanism, while edge cues are incorporated to enhance detail preservation in both highlight and shadow regions. The experimental results validate that the proposed framework can alleviate luminance inversion in HDRI when inputs are two EER images, and maintain fine structural details in complex HDR scenes. Full article