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7 Results Found

  • Article
  • Open Access
1 Citations
3,643 Views
14 Pages

28 November 2018

Motivated by known results in locally conformal symplectic geometry, we study different classes of G 2 -structures defined by a locally conformal closed 3-form. In particular, we provide a complete characterization of invariant exact locally c...

  • Article
  • Open Access
14 Citations
3,608 Views
13 Pages

Structural Basis for the Regiospecificity of a Lipase from Streptomyces sp. W007

  • Zexin Zhao,
  • Siyue Chen,
  • Long Xu,
  • Jun Cai,
  • Jia Wang and
  • Yonghua Wang

The efficiency and accuracy of the synthesis of structural lipids are closely related to the regiospecificity of lipases. Understanding the structural mechanism of their regiospecificity contributes to the regiospecific redesign of lipases for meetin...

  • Article
  • Open Access
11 Citations
3,572 Views
16 Pages

Cytochrome P450 3A7 (CYP3A7) is a fetal/neonatal liver enzyme that participates in estriol synthesis, clearance of all-trans retinoic acid, and xenobiotic metabolism. Compared to the closely related major drug-metabolizing enzyme in adult liver, CYP3...

  • Article
  • Open Access
5 Citations
2,870 Views
22 Pages

General Trends of the Camelidae Antibody VHHs Domain Dynamics

  • Akhila Melarkode Vattekatte,
  • Julien Diharce,
  • Joseph Rebehmed,
  • Frédéric Cadet,
  • Fabrice Gardebien,
  • Catherine Etchebest and
  • Alexandre G. de Brevern

24 February 2023

Conformational flexibility plays an essential role in antibodies’ functional and structural stability. They facilitate and determine the strength of antigen–antibody interactions. Camelidae express an interesting subtype of single-chain a...

  • Review
  • Open Access
28 Citations
5,429 Views
27 Pages

Proton and Heavy Particle Intracranial Radiosurgery

  • Eric J. Lehrer,
  • Arpan V. Prabhu,
  • Kunal K. Sindhu,
  • Stanislav Lazarev,
  • Henry Ruiz-Garcia,
  • Jennifer L. Peterson,
  • Chris Beltran,
  • Keith Furutani,
  • David Schlesinger and
  • Daniel M. Trifiletti
  • + 1 author

Stereotactic radiosurgery (SRS) involves the delivery of a highly conformal ablative dose of radiation to both benign and malignant targets. This has traditionally been accomplished in a single fraction; however, fractionated approaches involving fiv...

  • Article
  • Open Access
7 Citations
3,013 Views
16 Pages

26 October 2023

The robustness, safety, versatility, and high immunogenicity of virus-like particles (VLPs) make them a promising approach for the generation of vaccines against a broad range of pathogens. VLPs are recombinant macromolecular structures that closely...

  • Article
  • Open Access
7 Citations
3,635 Views
17 Pages

Potential Target Site for Inhibitors in MLSB Antibiotic Resistance

  • Hak Jin Lee,
  • Seong Tae Jhang and
  • Hyung Jong Jin

Macrolide–lincosamide–streptogramin B antibiotic resistance occurs through the action of erythromycin ribosome methylation (Erm) family proteins, causing problems due to their prevalence and high minimal inhibitory concentration, and feasibilities ha...