Search Results (2,425)

Quinoa protein isolate (QPI) and sodium alginate (SA) have excellent biocompatibility and functional properties, making them promising candidates for food-grade delivery systems. In this study, we developed, for the first time, a QPI/SA complex-stabilized Pickering emulsion for curcumin encapsulation. The coacervation behavior of QPI and SA was investigated from pH 1.6 to 7.5, and the structural and interfacial characteristics of the complexes were analyzed using zeta potential measurements, Fourier-transform infrared spectroscopy, scanning electron microscopy, and contact angle analysis. The results showed that the formation of QPI/SA complexes was primarily driven by electrostatic interactions, hydrogen bonding, and hydrophobic interactions, with enhanced amphiphilicity observed under optimal conditions (QPI/SA = 5:1, pH 5). The QPI/SA-stabilized Pickering emulsions demonstrated excellent emulsification performance and storage stability, maintaining an emulsification index above 90% after 7 d when prepared with 60% oil phase. In vitro digestion studies revealed stage-specific curcumin release, with sustained release in simulated gastric fluid (21.13%) and enhanced release in intestinal fluid (88.21%). Cytotoxicity assays using HeLa cells confirmed the biocompatibility of QPI/SA complexes (≤500 μg/mL), while curcumin-loaded emulsions exhibited dose-dependent anticancer activity. These findings suggest that QPI/SA holds significant potential for applications in functional foods and oral delivery systems. Full article

Objectives: This study assessed the effectiveness of a cognitive behavioral therapy (CBT)-based fine dust education program, grounded in the Health Belief Model (HBM), on elementary students’ fine dust knowledge, related behaviors, and mental health (depression, anxiety, stress, sleep quality). Methods: From September to November 2024, 95 students (grades 4–6) living near a coal-fired power plant in midwestern South Korea were assigned to either an intervention group (n = 44) or a control group (n = 51). The intervention group completed a three-session CBT-based education program; the control group received stress management education. Assessments were conducted at weeks 1, 2, 4, and 8 using standardized mental health and behavior scales (PHQ: Patient Health Questionnaire, GAD: Generalized Anxiety Disorder Assessment, PSS: Perceived Stress Scale, ISI: Insomnia Severity Index). Results: A chi-square test was conducted to compare pre- and post-test changes in knowledge and behavior related to PM2.5. The intervention group showed significant improvements in seven fine dust-related knowledge and behavior items (e.g., PM2.5 awareness rose from 33.3% to 75.0%; p < 0.05). The control group showed limited gains. Regarding mental health, based on a mixed-design ANCOVA, anxiety scores significantly declined over time in the intervention group, with group and interaction effects also significant (p < 0.05). Depression scores showed time effects, but group and interaction effects were not significant. No significant changes were observed for stress, sleep, or group × PM2.5 interactions. Conclusions: The CBT-based education program effectively enhanced fine dust knowledge, health behaviors, and reduced anxiety among students. It presents a promising, evidence-based strategy to promote environmental and mental health in school-aged children. Full article

Static analysis is conducted for functionally graded material (FGM) spherical shells under thermo-mechanical loads, based on the three-dimensional thermo-elasticity theory. The material properties, which vary with both the radial coordinate and temperature, introduce nonlinearity to the problem. To address this, a layer model is proposed, wherein the shell is discretized into numerous concentric spherical layers, each possessing uniform material properties. Within this framework, the nonlinear heat conduction equations are first solved iteratively. The resulting temperature field is then applied to the thermo-elastic equations, which are subsequently solved using a combined state space and transfer matrix method to obtain displacement and stress solutions. Comparison with existing literature results demonstrates good agreement. Finally, a parametric study is presented to investigate the effects of material temperature dependence and gradient index on the thermo-mechanical behaviors of the FGM spherical shells. Full article

Pavement skid resistance is of vital importance for road safety. The objective of this study is to propose and validate a texture-based image indicator to predict pavement friction. This index enables pavement friction to be predicted easily and inexpensively using digital images, with predictions correlated to Dynamic Friction Tester (DFT) measurements. Three different types of asphalt surfaces (Dense-Grade Asphalt Concrete, Open-Grade Friction Course, and Chip Seal) were evaluated subject to various tire polishing cycles. Images were taken with corresponding friction coefficients obtained using DFT in the laboratory. The aggregate protrusion area is proposed as the indicator. Statistical models are established for each asphalt surface type to correlate the proposed indicator with friction coefficients. The results show that the adjusted R-squared values of all relationships are above 0.90. Compared to other image-based indicators in the literature, the proposed image indicator more accurately reflects the changes in pavement friction with the number of polishing cycles, proving its cost-effective use for considering pavement friction in the mix design stage. Full article

This study evaluates the influence of fiber type, geometry, and interfacial behavior on the physical and mechanical performance of cementitious composites reinforced with recycled pulp from beverage cartons (RPBC), bamboo fiber (BF), and eucalyptus fiber (EF) as the sole reinforcing agents. The BF was rounded in shape and had the highest aspect ratio, while the ribbon-shaped EF exhibited the highest tensile strength index. The RPBC fibers were fibrillated and the shortest, with a ribbon shape. Flexural strength results showed that RPBCC achieved a maximum strength that was 47.6% higher than the control specimen (0% fiber), outperforming both BF- and EF-reinforced counterparts. This superior performance is attributed to the higher fibrillation level of the ribbon-shaped RPBC fibers, which promoted better fiber–matrix bonding. As the fiber content increased, the bulk density of EFC and BFC decreased linearly, while RPBC composites showed only a modest decrease in density. Porosity steadily increased in EFC and BFC, whereas a non-linear trend was observed in RPBCC, likely due to its unique morphology and fibrillation. Conversely, EFC exhibited significantly higher maximum fracture toughness (3600 J/m² at 10 wt.%) compared to PBFCC (1600 J/m² at 14 wt.%) and BFC (1400 J/m² at 14 wt.%). This enhancement is attributed to extensive fiber pullout mechanisms and increased energy absorption during crack propagation. Overall, all composite types demonstrated flexural strength values above 4 MPa, placing them in the Grade I category. Those reinforced with 10–14% RPBC exhibited strengths of 11–12 MPa, categorizing them as Grade II according to ASTM C1186-02. Full article

Background/Objectives: The 2019 WHO classification redefined high-grade gastrointestinal neuroendocrine neoplasms (GI NENs), encompassing not only poorly differentiated neuroendocrine carcinomas (NECs), but also well-differentiated grade 3 neuroendocrine tumors (NETs G3). Since both subtypes share a Ki-67 index > 20%, distinguishing them based solely on morphology is challenging. Prior studies have shown TP53 alterations in NECs but not in NETs. This study aimed to evaluate clinico-morphological parameters and the immunohistochemical (IHC) expression of p53 in high-grade GI NENs to identify relevant correlations. Methods: Tumors were stratified by Ki-67 index into two groups: >20–50% and >50%. p53 IHC expression was assessed as “wild-type” (1–20% positive tumor cells) or “non-wild-type” (absence or >20% positivity). Correlations were analyzed between Ki-67, p53 status, and various pathological features. Results: Significant correlations were found between the Ki-67 index and maximum tumor size, pT stage, lymphovascular invasion, perineural infiltration, and diagnostic classification. Similarly, p53 immunohistochemical status was significantly associated with lymphovascular invasion, lymph node metastasis, and tumor classification (NET G3 versus NEC, including NEC components of MiNENs). Conclusions: The findings support the value of Ki-67 and p53 as complementary biomarkers in the pathological evaluation of high-grade GI NENs. Their significant associations with key morphological parameters support their utility in differentiating NETs G3 from NECs, particularly in cases showing overlapping histological features. The immunohistochemical profile of p53 may serve as a useful diagnostic adjunct in routine practice. Full article

Background: Immunization is a highly effective intervention for controlling over 20 life-threatening infectious diseases, significantly reducing both morbidity and mortality rates. One notable achievement in vaccination efforts was the global eradication of smallpox, which the World Health Assembly declared on 8 May 1980. Additionally, there has been a remarkable 99.9% reduction in wild poliovirus cases since 1988, decreasing from more than 350,000 cases that year to just 30 cases in 2022. Objectives: The objective of this review was to assess the effects of various interventions designed to increase vaccination uptake among adults. Search Methods: A thorough search was conducted in the CENTRAL, Embase Ovid, Medline Ovid, PubMed, Web of Science, and Global Index Medicus databases for primary studies. This search was conducted in August 2021 and updated in November 2024. Selection Criteria: Randomized trials were eligible for inclusion in this review, regardless of publication status or language. Data Analysis: Two authors independently screened the search outputs to select potentially eligible studies. Risk ratios (RR) with 95% confidence intervals (CI) were calculated for each randomized controlled trial (RCT). A meta-analysis was conducted using a random-effects model, and the quality of the evidence was assessed using the GRADE approach. Main Results: A total of 35 randomized controlled trials met the inclusion criteria and were included in this review, with the majority conducted in the United States. The interventions targeted adults aged 18 and older who were eligible for vaccination, involving a total of 403,709 participants. The overall pooled results for interventions aimed at increasing influenza vaccination showed a risk ratio of 1.41 (95% CI: 1.15, 1.73). Most studies focused on influenza vaccination (18 studies), while the remaining studies examined various other vaccines, including those for hepatitis A, COVID-19, hepatitis B, pneumococcal disease, tetanus, diphtheria, pertussis (Tdap), herpes zoster, and human papillomavirus (HPV). The results indicate that letter reminders were slightly effective in increasing influenza vaccination uptake compared to the control group (RR: 1.75, 95% CI: 0.97, 1.16; 6 studies; 161,495 participants; low-certainty evidence). Additionally, participants who received education interventions showed increased levels of influenza vaccination uptake compared to those in the control group (RR: 1.88, 95% CI: 0.61, 5.76; 3 studies; 1318 participants; low-certainty evidence). Furthermore, tracking and outreach interventions also led to an increase in influenza vaccination uptake (RR: 1.87, 95% CI: 0.78, 4.46; 2 studies; 33,752 participants; low-certainty evidence). Conclusions: Letter reminders and educational interventions targeted at recipients are effective in increasing vaccination uptake compared to control groups. Full article

With climate change, the spatial and temporal patterns of precipitation are altered to a certain degree, which potentially affects the grey water footprint (GWF) of total nitrogen (TN) in agriculture, thereby threatening water security in the Yangtze River Basin (YRB), the largest river in China. The current study constructs an assessment framework for climate change impacts on the GWF of agricultural TN by coupling Shared Socioeconomic Pathways (SSPs) with the InVEST model. The framework consists of four components: (i) data collection and processing, (ii) simulating the two critical indicators (L_TN and W) in the GWF model based on the InVEST model, (iii) calculating the GWF and GWF index (GI) of TN, and (iv) calculating climate change impact index on GWF of agricultural TN (CI) under two SSPs. It is applied to the YRB, and the results show the following: (i) GWFs are 959.7 and 961.4 billion m³ under the SSP1-2.6 and SSP5-8.5 climate scenarios in 2030, respectively, which are both lower than that in 2020 (1067.1 billion m³). (ii) The GI values for TN in 2030 under SSP1-2.6 and SSP5-8.5 remain at “High” grade, with the values of 0.95 and 1.03, respectively. Regionally, the water pollution level of Taihu Lake is the highest, while that of Wujiang River is the lowest. (iii) The CI values of the YRB in 2030 under SSP1-2.6 and SSP5-8.5 scenarios are 0.507 and 0.527, respectively. And the CI values of the five regions in the YRB are greater than 0, indicating that the negative effects of climate change on GWFs increase. (iv) Compared with 2020, L_TN and W in YRB in 2030 under the two SSPs decrease, while the GI of TN in YRB rises from SSP1-2.6 to SSP5-8.5. The assessment framework can provide strategic recommendations for sustainable water resource management in the YRB and other regions globally under climate change. Full article

Cultivated land quality is a key factor in ensuring sustainable agricultural development. Exploring differences in cultivated land quality under distinct cropping systems is essential for developing targeted improvement strategies. This study takes place in Shenyang City—located in the typical black soil region of Northeast China—as a case area to construct a cultivated land quality evaluation system comprising 13 indicators, including organic matter, effective soil layer thickness, and texture configuration. A minimum data set (MDS) was separately extracted for paddy and upland fields using principal component analysis (PCA) to conduct a comprehensive evaluation of cultivated land quality. Additionally, an obstacle degree model was employed to identify the limiting factors and quantify their impact. The results indicated the following. (1) Both MDSs consisted of seven indicators, among which five were common: ≥10 °C accumulated temperature, available phosphorus, arable layer thickness, irrigation capacity, and organic matter. Parent material and effective soil layer thickness were unique to paddy fields, while landform type and soil texture were unique to upland fields. (2) The cultivated land quality index (CQI) values at the sampling point level showed no significant difference between paddy (0.603) and upland (0.608) fields. However, their spatial distributions diverged significantly; paddy fields were dominated by high-grade land (Grades I and II) clustered in southern areas, whereas uplands were primarily of medium quality (Grades III and IV), with broader spatial coverage. (3) Major constraint factors for paddy fields were effective soil layer thickness (21.07%) and arable layer thickness (22.29%). For upland fields, the dominant constraints were arable layer thickness (27.57%), organic matter (25.40%), and ≥10 °C accumulated temperature (23.28%). Available phosphorus and ≥10 °C accumulated temperature were identified as shared constraint factors affecting quality classification in both systems. In summary, cultivated land quality under different cropping systems is influenced by distinct limiting factors. The construction of cropping-system-specific MDSs effectively improves the efficiency and accuracy of cultivated land quality assessment, offering theoretical and methodological support for land resource management in the black soil regions of China. Full article

Research results suggest the potential of topical adenosine as a hair-promoting agent. The aim of this study was to examine the available clinical evidence of the efficacy of topical adenosine products in hair loss. This systematic review was conducted in accordance with PRISMA and PICO guidelines and included articles indexed in PubMed, Scopus, and Web of Science. The strength of evidence was assessed according to the GRADE system. Wherever feasible, data were extracted for a meta-analysis. Among 8625 articles returned by the query, 7 clinical trials were identified of topical adenosine (lotion, shampoo) in hair loss. They unanimously reported on a reduction in hair loss and increase in hair density (strength of evidence very low to moderate). A meta-analysis of three eligible trials showed a tendency to increased hair density (OR = 1.03, 95% CI: 0.89–1.20, p = 0.68), an increase in thick hair (OR = 1.4, 95% CI: 0.82–2.38, p = 0.21) and a decrease in thin hairs (OR = 0.93, 95% CI: 0.61–1.43, p = 0.75) after 6 months of alopecia treatment with a 0.75% adenosine lotion. The results from clinical trials published until now suggest that topical adenosine increases hair thickness, reduces excessive hair loss, stimulates hair regrowth, and increases hair density. The overall strength of evidence remains low due to flawed design and small sample sizes in most trials. Nevertheless, topical adenosine products seem worth trying, especially in the case of contraindications or adverse effects to approved medicinal products for hair loss. Further, better designed trials of adenosine in hair loss are warranted. Full article

Background: Renal trauma accounts for approximately 3–5% of all trauma cases, predominantly affecting young males. The most common etiology is blunt trauma, particularly due to road traffic accidents, and it frequently occurs as part of polytrauma involving multiple organ systems. Management strategies are primarily dictated by hemodynamic stability, overall clinical condition, comorbidities, and injury severity graded according to the AAST classification. This study aimed to evaluate the effectiveness of non-operative management (NOM) in high-grade renal trauma (AAST grades III–V), beyond its established role in low-grade injuries (grades I–II). Secondary endpoints included the identification of independent prognostic factors for NOM failure and in-hospital mortality. Methods: We conducted a retrospective observational study including patients diagnosed with blunt renal trauma who presented to the Emergency Department of Policlinico Umberto I in Rome between 1 January 2013 and 30 April 2024. Collected data comprised demographics, trauma mechanism, vital signs, hemodynamic status (shock index), laboratory tests, blood gas analysis, hematuria, number of transfused RBC units in the first 24 h, AAST renal injury grade, ISS, associated injuries, treatment approach, hospital length of stay, and mortality. Statistical analyses, including multivariable logistic regression, were performed using SPSS v28.0. Results: A total of 244 patients were included. Low-grade injuries (AAST I–II) accounted for 43% (n = 105), while high-grade injuries (AAST III–V) represented 57% (n = 139). All patients with low-grade injuries were managed non-operatively. Among high-grade injuries, 124 patients (89%) were treated with NOM, including observation, angiography ± angioembolization, stenting, or nephrostomy. Only 15 patients (11%) required nephrectomy, primarily due to persistent hemodynamic instability. The overall mortality rate was 13.5% (33 patients) and was more closely associated with the overall injury burden than with renal injury severity. Multivariable analysis identified shock index and active bleeding on CT as independent predictors of NOM failure, whereas ISS and age were significant predictors of in-hospital mortality. Notably, AAST grade did not independently predict either outcome. Conclusions: In line with the current international literature, our study confirms that NOM is the treatment of choice not only for low-grade renal injuries but also for carefully selected hemodynamically stable patients with high-grade trauma. Our findings highlight the critical role of physiological parameters and overall ISS in guiding management decisions and underscore the need for individualized assessment to minimize unnecessary nephrectomies and optimize patient outcomes. Full article

Kernel test weight (KTW) is one of the important assessment indexes of maize quality grade and one of the important influencing factors of yield. This study analyzed 12 traits related to KTW in 321 maize inbred lines using multivariate methods. The principal component analysis (PCA) indicated that the four PCs covered 78.176% of the information of the 12 traits in 321 maize inbred lines. Cluster analysis categorized the maize lines into six groups, identifying 16 elite inbred lines with the highest KTW. A stepwise regression model for KWT evaluation was developed using four PCA traits: starch content, amylopectin content, 100-kernel weight, and kernel circumference. The findings of this study serve as a valuable reference point for the genetic improvement of maize germplasm re-sources in kernel test weight and the creation of high kernel test weight maize resources. Full article

In this study, a magnet-integrated fabric phase sorptive extraction (MI-FPSE) protocol was developed in combination with high pressure liquid chromatography—diode array detection (HPLC-DAD) for the simultaneous determination of five phenylurea pesticides (i.e., chlorbromuron, diuron, linuron, metoxuron, monuron) in environmental water samples. To produce the MI-FPSE device, two individual sol-gel coated carbowax 20 M (CW 20 M) cellulose membranes were fabricated and stitched to each other, while a magnetic rod was inserted between them to give the resulting device the ability to spin and serve as a stand-alone microextraction platform. The adsorption and desorption step of the MI-FPSE protocol was optimized to achieve high extraction efficiency and the MI-FPSE-HPLC-DAD method was validated in terms of linearity, sensitivity, selectivity, accuracy, and precision. The limits of detection (LODs) were found to be 0.3 μg L⁻¹. The relative recoveries were 85.2–110.0% for the intra-day and 87.7–103.2% for the inter-day study. The relative standard deviations were better than 13% in all cases. The green character and the practicality of the developed procedure were assessed using ComplexGAPI and Blue Analytical Grade Index metric tools, showing good method performance. Finally, the developed method was successfully used for the analysis of tap, river, and lake water samples. Full article

Rizhao Reservoir, Shandong Province, China, as a key regional water supply hub, provides water for domestic, industrial, and agricultural uses in and around Rizhao City by intercepting runoff, which plays a central role in guaranteeing water supply security and supporting regional development. This study systematically collected 66 surface water samples to elucidate the hydrochemical characteristics within the reservoir area, identify the principal influencing factors, and clarify the sources of dissolved ions, aiming to enhance the understanding of the prevailing water quality conditions. A systematic analysis of hydrochemical facies, solute provenance, and governing processes in the study area’s surface water was conducted, employing an integrated mathematical and statistical approach, comprising Piper trilinear diagrams, correlation analysis, and ionic ratios. Meanwhile, the entropy weight-based water quality index (EWQI) and irrigation water quality evaluation methods were employed to assess the surface water quality in the study area quantitatively. Analytical results demonstrate that the surface water system within the study area is classified as freshwater with circumneutral to slightly alkaline properties, predominantly characterized by Ca-HCO₃ and Ca-Mg-SO₄-Cl hydrochemical facies. The evolution of solute composition is principally governed by rock–water interactions, whereas anthropogenic influences and cation exchange processes exert comparatively minor control. Dissolved ions mostly originate from silicate rock weathering, carbonate rock dissolution, and sulfate mineral dissolution processes. Potability assessment via the entropy-weighted water quality index (EWQI) classifies surface waters in the study area as Grade I (Excellent), indicating compliance with drinking water criteria under defined boundary conditions. Irrigation suitability analysis confirms minimal secondary soil salinization risk during controlled agricultural application, with all samples meeting standards for direct irrigation use. Full article

This study explored the potential of chitosan (CH)/bacterial cellulose (BC) complexes (0.5% w/v) as novel emulsifiers to stabilize oil-in-water (o/w) Pickering emulsions (20% v/v sunflower oil), with a focus on their gel-like behavior. Emulsions were prepared using CH combined with BNC derived via H₂SO₄ (BNC1) or H₂SO₄-HCl (BNC2) hydrolysis. Increasing BNC content improved stability by reducing phase separation and enhancing viscosity, while CH contributed interfacial activity and electrostatic stabilization. CH/BNC1_25:75 emulsions showed the highest stability, maintaining an emulsion stability index (ESI) of up to 100% after 3 days, with minimal change in droplet size (R_h ~8.5–8.8 μm) and a positive ζ-potential (15.1–29.8 mV), as confirmed by dynamic/electrophoretic light scattering. pH adjustment to 4 and 10 had little effect on their ESI, while ionic strength studies showed that 0.1 M NaCl caused only a slight increase in droplet size combined with the highest ζ-potential (−35.2 mV). Higher salt concentrations led to coalescence and disruption of their gel-like structure. Rheological analysis of CH/BNC1_25:75 emulsions revealed shear-thinning behavior and dominant elastic properties (G′ > G″), indicating a soft gel network. Incorporating sunflower-seed protein isolates into CH/BNC1 (25:75) emulsions led to coacervate formation (three-layer system), characterized by a decrease in droplet size and an increase in ζ-potential (up to 32.8 mV) over 7 days. These findings highlight CH/BNC complexes as sustainable stabilizers for food-grade Pickering emulsions, supporting the development of biopolymer-based emulsifiers aligned with bioeconomy principles. Full article