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8 Results Found

  • Feature Paper
  • Review
  • Open Access
70 Citations
14,906 Views
20 Pages

Synthesis of Glycosides by Glycosynthases

  • Marc R. Hayes and
  • Jörg Pietruszka

30 August 2017

The many advances in glycoscience have more and more brought to light the crucial role of glycosides and glycoconjugates in biological processes. Their major influence on the functionality and stability of peptides, cell recognition, health and immun...

  • Article
  • Open Access
10 Citations
3,888 Views
20 Pages

A Fungal Versatile GH10 Endoxylanase and Its Glycosynthase Variant: Synthesis of Xylooligosaccharides and Glycosides of Bioactive Phenolic Compounds

  • Ana Pozo-Rodríguez,
  • Juan A. Méndez-Líter,
  • Laura I. de Eugenio,
  • Manuel Nieto-Domínguez,
  • Eva Calviño,
  • Francisco Javier Cañada,
  • Andrés G. Santana,
  • Jaime Díez,
  • Juan L. Asensio and
  • Jorge Barriuso
  • + 2 authors

26 January 2022

The study of endoxylanases as catalysts to valorize hemicellulosic residues and to obtain glycosides with improved properties is a topic of great industrial interest. In this work, a GH10 β-1,4-endoxylanase (XynSOS), from the ascomycetous fungus...

  • Review
  • Open Access
9 Citations
7,689 Views
17 Pages

13 June 2013

In the early days of biocatalysis, limitations of an enzyme modeled the enzymatic applications; nowadays the enzyme can be engineered to be suitable for the process requirements. This is a general bird’s-eye view and as such cannot be specific for ar...

  • Review
  • Open Access
6 Citations
2,289 Views
18 Pages

13 September 2023

Chitooligosaccharides (COSs) are b-1,4-linked homo-oligosaccharides of N-acetylglucosamine (GlcNAc) or glucosamine (GlcN), and also include hetero-oligosaccharides composed of GlcNAc and GlcN. These sugars are of practical importance because of their...

  • Article
  • Open Access
5 Citations
3,296 Views
16 Pages

Synthesis and Characterization of a Novel Resveratrol Xylobioside Obtained Using a Mutagenic Variant of a GH10 Endoxylanase

  • Ana Pozo-Rodríguez,
  • Juan A. Méndez-Líter,
  • Rocío García-Villalba,
  • David Beltrán,
  • Eva Calviño,
  • Andrés G. Santana,
  • Laura I. de Eugenio,
  • Francisco Javier Cañada,
  • Alicia Prieto and
  • Jorge Barriuso
  • + 2 authors

30 December 2022

Resveratrol is a natural polyphenol with antioxidant activity and numerous health benefits. However, in vivo application of this compound is still a challenge due to its poor aqueous solubility and rapid metabolism, which leads to an extremely low bi...

  • Review
  • Open Access
13 Citations
7,578 Views
24 Pages

24 September 2015

Most of the reports in literature dedicated to the use of glycosyl hydrolases for the preparation of glycosides are about gluco- (α- and β-form) and galacto-sidase (β-form), reflecting the high-availability of both anomers of glucosides and of β-gala...

  • Article
  • Open Access
9 Citations
3,053 Views
16 Pages

Glycosylation of Epigallocatechin Gallate by Engineered Glycoside Hydrolases from Talaromyces amestolkiae: Potential Antiproliferative and Neuroprotective Effect of These Molecules

  • Juan A. Méndez-Líter,
  • Ana Pozo-Rodríguez,
  • Enrique Madruga,
  • María Rubert,
  • Andrés G. Santana,
  • Laura I. de Eugenio,
  • Cristina Sánchez,
  • Ana Martínez,
  • Alicia Prieto and
  • María Jesús Martínez

Glycoside hydrolases (GHs) are enzymes that hydrolyze glycosidic bonds, but some of them can also catalyze the synthesis of glycosides by transglycosylation. However, the yields of this reaction are generally low since the glycosides formed end up be...

  • Review
  • Open Access
32 Citations
8,492 Views
28 Pages

Enzymatic Glycosylation Strategies in the Production of Bioactive Compounds

  • Alicia Andreu,
  • Marija Ćorović,
  • Carla Garcia-Sanz,
  • A. Sofia Santos,
  • Ana Milivojević,
  • Clara Ortega-Nieto,
  • Cesar Mateo,
  • Dejan Bezbradica and
  • Jose M. Palomo

11 October 2023

Enzymatic glycosylation is a versatile and sustainable biotechnological approach that plays a pivotal role in the production of bioactive compounds. This process involves the enzymatic transfer of sugar moieties onto various acceptor molecules, such...