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Article

9 Citations

3,541 Views

25 Pages

Arginine Gemini-Based Surfactants for Antimicrobial and Antibiofilm Applications: Molecular Interactions, Skin-Related Anti-Enzymatic Activity and Cytotoxicity

Francisco Fábio Oliveira de Sousa,
Aurora Pinazo,
Zakaria Hafidi,
María Teresa García,
Elena Bautista,
Maria del Carmen Moran and
Lourdes Pérez

Molecules2023, 28(18), 6570;https://doi.org/10.3390/molecules28186570

11 September 2023

The antimicrobial and antibiofilm properties of arginine-based surfactants have been evaluated. These two biological properties depend on both the alkyl chain length and the spacer chain nature. These gemini surfactants exhibit good activity against...

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Article

13 Citations

4,131 Views

31 Pages

Zein Nanoparticles Containing Arginine-Based Surfactants: Physicochemical Characterization and Effect on the Biological Properties

Lourdes Pérez,
Adrià Sentís,
Zakaria Hafidi,
Aurora Pinazo,
Maria Teresa García,
Manuel Martín-Pastor and
Francisco Fábio Oliveira de Sousa

Int. J. Mol. Sci.2023, 24(3), 2568;https://doi.org/10.3390/ijms24032568

29 January 2023

Cationic surfactants carry antimicrobial activity, based on their interaction and disruption of cell membranes. Nonetheless, their intrinsic toxicity limits their applicability. To overcome this issue, a feasible strategy consists of using solid nano...

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Article

23 Citations

4,889 Views

24 Pages

Biocompatible Catanionic Vesicles from Arginine-Based Surfactants: A New Strategy to Tune the Antimicrobial Activity and Cytotoxicity of Vesicular Systems

Aurora Pinazo,
Ramon Pons,
Ana Marqués,
Maribel Farfan,
Anderson da Silva and
Lourdes Perez

Pharmaceutics2020, 12(9), 857;https://doi.org/10.3390/pharmaceutics12090857

9 September 2020

Their stability and low cost make catanionic vesicles suitable for application as drug delivery systems. In this work we prepared catanionic vesicles using biocompatible surfactants: two cationic arginine-based surfactants (the monocatenary Nα-...

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Article

1 Citations

1,775 Views

17 Pages

Preventive Activity of an Arginine-Based Surfactant on the Formation of Mixed Biofilms of Fluconazole-Resistant Candida albicans and Extended-Spectrum-Beta-Lactamase-Producing Escherichia coli on Central Venous Catheters

Lourdes Pérez,
Cecília Rocha da Silva,
Lívia Gurgel do Amaral Valente Sá,
João Batista de Andrade Neto,
Vitória Pessoa de Farias Cabral,
Daniel Sampaio Rodrigues,
Lara Elloyse Almeida Moreira,
Maria Janielly Castelo Branco Silveira,
Thais Lima Ferreira and
Anderson Ramos da Silva
+ 4 authors

Antibiotics2025, 14(3), 227;https://doi.org/10.3390/antibiotics14030227

24 February 2025

Background/Objectives: Mixed bloodstream infections associated with central venous catheter (CVC) use are a growing problem. The aim of this study was to evaluate the activity of a cationic arginine-based gemini surfactant, C9(LA)2, against mixed bio...

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