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Article

Biocompatible Catanionic Vesicles from Arginine-Based Surfactants: A New Strategy to Tune the Antimicrobial Activity and Cytotoxicity of Vesicular Systems

1
Department of Surfactant and Nanobiotecnnology, Institute of Advanced Chemistry of Catalonia, IQAC-CSIC, c/Jordi Girona, 18-26, 08034 Barcelona, Spain
2
Department of Biology, Healthcare and the Environment, Section Microbiology, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(9), 857; https://doi.org/10.3390/pharmaceutics12090857
Received: 23 July 2020 / Revised: 1 September 2020 / Accepted: 5 September 2020 / Published: 9 September 2020
(This article belongs to the Special Issue Nanocarriers for Drug Delivery Systems)
Their stability and low cost make catanionic vesicles suitable for application as drug delivery systems. In this work we prepared catanionic vesicles using biocompatible surfactants: two cationic arginine-based surfactants (the monocatenary Nα-lauroyl-arginine methyl ester—LAM and the gemini Nα,Nϖ-bis(Nα-lauroylarginine) α, ϖ-propylendiamide—C3(CA)2) and three anionic amphiphiles (the single chain sodium dodecanoate, sodium myristate, and the double chain 8-SH). The critical aggregation concentration, colloidal stability, size, and charge density of these systems were comprehensively studied for the first time. These catanionic vesicles, which form spontaneously after mixing two aqueous solutions of oppositely charged surfactants, exhibited a monodisperse population of medium-size aggregates and good stability. The antimicrobial and hemolytic activity of the vesicles can be modulated by changing the cationic/anionic surfactant ratio. Vesicles with a positive charge efficiently killed Gram-negative and Gram-positive bacteria as well as yeasts; the antibacterial activity declined with the decrease of the cationic charge density. The catanionic systems also effectively eradicated MRSA (Methicillin-resistant Staphylococcus Aureus) and Pseudomonas aeruginosa biofilms. Interestingly, the incorporation of cholesterol in the catanionic mixtures improved the stability of these colloidal systems and considerably reduced their cytotoxicity without affecting their antimicrobial activity. Additionally, these catanionic vesicles showed good DNA affinity. Their antimicrobial efficiency and low hemolytic activity render these catanionic vesicles very promising candidates for biomedical applications. View Full-Text
Keywords: catanionic vesicles; amino acids; biocompatible surfactants; antimicrobial activity; antibiofilm activity; hemolysis; bacterial selectivity catanionic vesicles; amino acids; biocompatible surfactants; antimicrobial activity; antibiofilm activity; hemolysis; bacterial selectivity
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MDPI and ACS Style

Pinazo, A.; Pons, R.; Marqués, A.; Farfan, M.; da Silva, A.; Perez, L. Biocompatible Catanionic Vesicles from Arginine-Based Surfactants: A New Strategy to Tune the Antimicrobial Activity and Cytotoxicity of Vesicular Systems. Pharmaceutics 2020, 12, 857. https://doi.org/10.3390/pharmaceutics12090857

AMA Style

Pinazo A, Pons R, Marqués A, Farfan M, da Silva A, Perez L. Biocompatible Catanionic Vesicles from Arginine-Based Surfactants: A New Strategy to Tune the Antimicrobial Activity and Cytotoxicity of Vesicular Systems. Pharmaceutics. 2020; 12(9):857. https://doi.org/10.3390/pharmaceutics12090857

Chicago/Turabian Style

Pinazo, Aurora, Ramon Pons, Ana Marqués, Maribel Farfan, Anderson da Silva, and Lourdes Perez. 2020. "Biocompatible Catanionic Vesicles from Arginine-Based Surfactants: A New Strategy to Tune the Antimicrobial Activity and Cytotoxicity of Vesicular Systems" Pharmaceutics 12, no. 9: 857. https://doi.org/10.3390/pharmaceutics12090857

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