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38,221 Results Found

  • Review
  • Open Access
17 Citations
9,201 Views
35 Pages

Status and Challenges of Marine Current Turbines: A Global Review

  • Yajing Gu,
  • Tian Zou,
  • Hongwei Liu,
  • Yonggang Lin,
  • He Ren and
  • Qingjun Li

Over the past few decades, marine current energy utilization has transitioned from conceptual demonstrations to industrial-scale prototypes. This progression now approaches a crucial phase emphasizing the need for industrialization and commercializat...

  • Review
  • Open Access
2 Citations
7,163 Views
16 Pages

17 April 2025

Background and Objectives: Severe Traumatic Brain Injury (TBI) is one of the devastating injuries occurring in all ages across the globe. Despite many advancements in the management of severe TBI, mortality and morbidities remain high. Evidence-based...

  • Review
  • Open Access
92 Citations
11,596 Views
29 Pages

Current Challenges and Innovative Developments in Hydroxyapatite-Based Coatings on Metallic Materials for Bone Implantation: A Review

  • Bilal Beig,
  • Usman Liaqat,
  • Muhammad Farooq Khan Niazi,
  • Inamullah Douna,
  • Muhammad Zahoor and
  • Muhammad Bilal Khan Niazi

18 December 2020

Biomaterials are in use for the replacement and reconstruction of several tissues and organs as treatment and enhancement. Metallic, organic, and composites are some of the common materials currently in practice. Metallic materials contribute a big s...

  • Article
  • Open Access
116 Citations
14,903 Views
18 Pages

The severity of climate change and the urgency of ecological environment protection make the transformation of coal power imperative. In this paper, the relevant policies of coal-biomass co-firing power generation are combed, and the technical and ec...

  • Review
  • Open Access
390 Views
21 Pages

1 February 2026

This review examines the status, challenges, and future trajectories of global mussel aquaculture within the blue food system. Despite steady production growth, mussels’ relative contribution to total bivalve output has significantly declined o...

  • Review
  • Open Access
5 Citations
6,409 Views
13 Pages

Current Challenges in Pediatric Asthma

  • Andrija Miculinić,
  • Iva Mrkić Kobal,
  • Tin Kušan,
  • Mirjana Turkalj and
  • Davor Plavec

Asthma is a chronic lung disease characterized by reversible bronchoconstriction and inflammation of the bronchi. Its increasing prevalence in childhood as well as different triggers make asthma a challenging disease in several ways: defining its phe...

  • Review
  • Open Access
16 Citations
6,434 Views
12 Pages

Current Challenges in Breast Implantation

  • Zuzanna Pelc,
  • Magdalena Skórzewska,
  • Andrzej Kurylcio,
  • Paweł Olko,
  • Joanna Dryka,
  • Piotr Machowiec,
  • Marcela Maksymowicz,
  • Karol Rawicz-Pruszyński and
  • Wojciech Polkowski

7 November 2021

Breast implantation (BI) is the most common plastic surgery worldwide performed among women. Generally, BI is performed both in aesthetic and oncoplastic procedures. Recently, the prevalence of breast implant-associated anaplastic large cell lymphoma...

  • Review
  • Open Access
116 Citations
8,516 Views
41 Pages

Current Challenges and Opportunities of Photodynamic Therapy against Cancer

  • Ruben V. Huis in ‘t Veld,
  • Jeroen Heuts,
  • Sen Ma,
  • Luis J. Cruz,
  • Ferry A. Ossendorp and
  • Martine J. Jager

BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are generated that ultimately induce cell death and disruption of the tumor area. Moreover,...

  • Review
  • Open Access
3 Citations
3,161 Views
16 Pages

Current Challenges in Coronary Bifurcation Interventions

  • Panayot Panayotov,
  • Niya Mileva and
  • Dobrin Vassilev

3 September 2024

Coronary bifurcation lesions account for a significant proportion of all percutaneous coronary interventions (PCIs). Interventional treatment of coronary bifurcations is related to significant technical challenges, high complication rates, and worse...

  • Editorial
  • Open Access
4 Citations
2,035 Views
2 Pages

Chronic Diabetic Complications: Current Challenges and Opportunities

  • Ilias N. Migdalis,
  • Leszek Czupryniak,
  • Nebojsa Lalic,
  • Nikolaos Papanas and
  • Paul Valensi

28 January 2022

The Special Issue, “Chronic Diabetic Complications: Current Challenges and Opportunities”, is rich in scientific content, covering a wide field of diabetic complications via both original studies and reviews [...]

  • Review
  • Open Access
190 Citations
26,374 Views
22 Pages

Algal Biofuels: Current Status and Key Challenges

  • Marwa G. Saad,
  • Noura S. Dosoky,
  • Mohamed S. Zoromba and
  • Hesham M. Shafik

20 May 2019

The current fossil fuel reserves are not sufficient to meet the increasing demand and very soon will become exhausted. Pollution, global warming, and inflated oil prices have led the quest for renewable energy sources. Algal biofuels represent a pote...

  • Article
  • Open Access
83 Citations
15,927 Views
20 Pages

20 July 2018

This study presents a critical analysis of the environmental challenges regarding global environmental policies and current practices in China. The study provides imperative evidence about the current emission control strategies, environmental planni...

  • Perspective
  • Open Access
3,505 Views
15 Pages

19 November 2025

Biopharmaceuticals are medical drugs produced by means of biotechnology. In contrast with small-molecule (traditional) drugs, which are usually synthesized chemically, biopharmaceuticals are derived from biological sources, including tissues, cells,...

  • Review
  • Open Access
14 Citations
6,042 Views
19 Pages

Current Challenges and Issues in the Application of Astaxanthin

  • Limin Peng,
  • Zhiqiang Zhang,
  • Qing Li and
  • Hui Yang

4 April 2025

Astaxanthin, a xanthophyll carotenoid, exhibits potent biological functions, including antioxidant, immune regulation, growth promotion, improved reproductive capacity, and enhancement of the body color of aquatic animals. In recent years, with the r...

  • Review
  • Open Access
61 Citations
8,819 Views
19 Pages

Antioxidant Therapeutics in Parkinson’s Disease: Current Challenges and Opportunities

  • Ana Patricia Duarte-Jurado,
  • Yareth Gopar-Cuevas,
  • Odila Saucedo-Cardenas,
  • Maria de Jesus Loera-Arias,
  • Roberto Montes-de-Oca-Luna,
  • Aracely Garcia-Garcia and
  • Humberto Rodriguez-Rocha

Oxidative stress is considered one of the pathological mechanisms that cause Parkinson’s disease (PD), which has led to the investigation of several antioxidants molecules as a potential therapeutic treatment against the disease. Although preclinical...

  • Review
  • Open Access
44 Citations
13,177 Views
17 Pages

Enteric Fever Diagnosis: Current Challenges and Future Directions

  • Durga P. Neupane,
  • Hari P. Dulal and
  • Jeongmin Song

Enteric fever is a life-threatening systemic febrile disease caused by Salmonella enterica serovars Typhi and Paratyphi (S. Typhi and S. Paratyphi). Unfortunately, the burden of the disease remains high primarily due to the global spread of various d...

  • Review
  • Open Access
148 Citations
21,996 Views
20 Pages

Enzyme Therapy: Current Challenges and Future Perspectives

  • Miguel de la Fuente,
  • Laura Lombardero,
  • Alfonso Gómez-González,
  • Cristina Solari,
  • Iñigo Angulo-Barturen,
  • Arantxa Acera,
  • Elena Vecino,
  • Egoitz Astigarraga and
  • Gabriel Barreda-Gómez

25 August 2021

In recent years, enzymes have risen as promising therapeutic tools for different pathologies, from metabolic deficiencies, such as fibrosis conditions, ocular pathologies or joint problems, to cancer or cardiovascular diseases. Treatments based on th...

  • Review
  • Open Access
80 Citations
13,295 Views
33 Pages

26 March 2022

Ultrasonic ranging has been widely used in automobiles, unmanned aerial vehicles (UAVs), robots and other fields. With the appearance of micromachined ultrasonic transducers (MUTs), the application of ultrasonic ranging technology presents a more ext...

  • Article
  • Open Access
79 Citations
38,813 Views
11 Pages

2 July 2018

The study seeks to explore and synthesize current issues in Slow Fashion and discuss potential future directions of the industry. While there are multiple definitions of the term, Slow Fashion typically describes long-lasting, locally manufactured cl...

  • Review
  • Open Access
38 Citations
8,150 Views
18 Pages

Recycling Technologies for Biopolymers: Current Challenges and Future Directions

  • Adenike A. Akinsemolu,
  • Adetola M. Idowu and
  • Helen N. Onyeaka

30 September 2024

Plastic pollution is a major driver of climate change that is associated with biodiversity loss, greenhouse gas emissions, and negative soil, plant, animal, and human health. One of the solutions that has been proposed and is currently reducing the a...

  • Opinion
  • Open Access
43 Citations
7,124 Views
15 Pages

Current Challenges and Opportunities for Improved Cannabidiol Solubility

  • Khondker Rufaka Hossain,
  • Amani Alghalayini and
  • Stella M. Valenzuela

25 September 2023

Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to its potential therapeutic benefits. However, one of the challenges associated with CBD administration is its low bioavailability, which refers to the fraction...

  • Review
  • Open Access
33 Citations
7,085 Views
23 Pages

Immunotherapy for Glioblastoma: Current State, Challenges, and Future Perspectives

  • Minfeng Yang,
  • In Young Oh,
  • Arpan Mahanty,
  • Wei-Lin Jin and
  • Jung Sun Yoo

19 August 2020

Glioblastoma is the most lethal intracranial primary malignancy by no optimal treatment option. Cancer immunotherapy has achieved remarkable survival benefits against various advanced tumors, such as melanoma and non-small-cell lung cancer, thus trig...

  • Review
  • Open Access
10 Citations
7,306 Views
18 Pages

Oligometastatic NSCLC: Current Perspectives and Future Challenges

  • Sara Torresan,
  • Jacopo Costa,
  • Carol Zanchetta,
  • Lorenzo De Marchi,
  • Simona Rizzato and
  • Francesco Cortiula

Oligometastatic non-small cell lung cancer (NSCLC) represents a separate entity with a different biology and prognosis compared to stage IV NSCLC. Challenges range from the very definition of oligometastatic disease to the timing and techniques of lo...

  • Review
  • Open Access
76 Citations
37,188 Views
34 Pages

Water Resources in Jordan: A Review of Current Challenges and Future Opportunities

  • Mohammad Al-Addous,
  • Mathhar Bdour,
  • Mohammad Alnaief,
  • Shatha Rabaiah and
  • Norman Schweimanns

25 October 2023

Jordan is facing significant challenges related to water scarcity, including overexploitation of groundwater, increasing demand, and wasteful practices. Despite efforts to manage water resources, inadequate planning has resulted in ongoing water secu...

  • Review
  • Open Access
8 Citations
4,937 Views
9 Pages

Current AI Applications and Challenges in Oral Pathology

  • Zaizhen Xu,
  • Alice Lin and
  • Xiaoyuan Han

6 January 2025

Artificial intelligence (AI), particularly through machine learning (ML) and deep learning (DL) techniques such as convolutional neural networks (CNNs) and natural language processing (NLP), has shown remarkable promise in image analysis and clinical...

  • Article
  • Open Access
4 Citations
5,509 Views
17 Pages

Challenges in Contacting Metal–Polymer Current Collectors in Pouch Cells

  • Hakon Gruhn,
  • Tobias Krüger,
  • Malte Mund,
  • Maja W. Kandula and
  • Klaus Dilger

Recent research focuses on replacing metal current collectors with metallized polymer foils. However, this introduces significant challenges during cell production, as manufacturing steps must be adapted. Currently, copper is used as the current coll...

  • Review
  • Open Access
27 Citations
17,137 Views
35 Pages

Current State and Challenges of Tissue and Organ Cryopreservation in Biobanking

  • Irina V. Khaydukova,
  • Valeria M. Ivannikova,
  • Dmitry A. Zhidkov,
  • Nikita V. Belikov,
  • Maria A. Peshkova,
  • Peter S. Timashev,
  • Dmitry I. Tsiganov and
  • Aleksandr V. Pushkarev

16 October 2024

Recent years have witnessed significant advancements in the cryopreservation of various tissues and cells, yet several challenges persist. This review evaluates the current state of cryopreservation, focusing on contemporary methods, notable achievem...

  • Commentary
  • Open Access
38 Citations
7,978 Views
11 Pages

Soundscape research is attracting an ever-increasing worldwide interest from different disciplines and stakeholders. This brief commentary paper aims at offering some insights into the new directions this research (and practice) field will likely go,...

  • Review
  • Open Access
45 Citations
16,048 Views
21 Pages

The Skin Microbiome: Current Techniques, Challenges, and Future Directions

  • Tasha M. Santiago-Rodriguez,
  • Brice Le François,
  • Jean M. Macklaim,
  • Evgueni Doukhanine and
  • Emily B. Hollister

Skin acts as a barrier that promotes the colonization of bacteria, fungi, archaea, and viruses whose membership and function may differ depending on the various specialized niches or micro-environments of the skin. The group of microorganisms inhabit...

  • Review
  • Open Access
1 Citations
4,621 Views
33 Pages

29 September 2025

The Orthoflavivirus genus belongs to the Flaviviridae family. Orthoflaviviruses include major clinically relevant arthropod-borne human viruses such as Dengue, Zika, yellow fever, West Nile and tick-borne encephalitis virus. These viruses pose an inc...

  • Feature Paper
  • Communication
  • Open Access
11 Citations
6,070 Views
13 Pages

16 August 2019

Mechanobiology studies from the last decades have brought significant insights into many domains of biological research, from development to cellular signaling. However, mechano-regulation of subcellular components, especially membranous organelles,...

  • Article
  • Open Access
17 Citations
5,711 Views
15 Pages

Biocorrosion of Concrete Sewers in Greece: Current Practices and Challenges

  • Georgios Fytianos,
  • Vasilis Baltikas,
  • Dimitrios Loukovitis,
  • Dimitra Banti,
  • Athanasios Sfikas,
  • Efthimios Papastergiadis and
  • Petros Samaras

26 March 2020

This paper is intended to review the current practices and challenges regarding the corrosion of the Greek sewer systems with an emphasis on biocorrosion and to provide recommendations to avoid it. The authors followed a holistic approach, which incl...

  • Review
  • Open Access
8 Citations
9,186 Views
19 Pages

Maternal Immunization: Current Evidence, Progress, and Challenges

  • Veronica Santilli,
  • Mayla Sgrulletti,
  • Giorgio Costagliola,
  • Alessandra Beni,
  • Maria Felicia Mastrototaro,
  • Davide Montin,
  • Caterina Rizzo,
  • Baldassarre Martire,
  • Michele Miraglia del Giudice and
  • Viviana Moschese

24 April 2025

Maternal immunization is a key strategy for protecting pregnant individuals and newborns from infectious diseases. This review examines the mechanisms and benefits of maternal immunization, with a focus on transplacental IgG transfer and immune syste...

  • Review
  • Open Access
38 Citations
15,298 Views
20 Pages

23 October 2023

Prehospital care plays a critical role in improving patient outcomes, particularly in cases of time-sensitive emergencies such as trauma, cardiac failure, stroke, bleeding, breathing difficulties, systemic infections, etc. In recent years, there has...

  • Article
  • Open Access
3 Citations
3,433 Views
26 Pages

Additive Manufacturing of Copper—A Survey on Current Needs and Challenges

  • Moritz Benedikt Schäfle,
  • Michel Fett,
  • Julian Gärtner and
  • Eckhard Kirchner

Additive manufacturing (AM) of copper is subject to dynamic development regarding available processes and the quality of produced parts. While challenging, AM processes for copper provide parts with a quality comparable to other metallic material gro...

  • Review
  • Open Access
330 Citations
21,844 Views
10 Pages

Bladder Cancer: Current Challenges and Future Directions

  • Jakub Dobruch and
  • Maciej Oszczudłowski

24 July 2021

Bladder cancer (BCa) is the most common malignancy of the urinary tract and one of the most prevalent cancers worldwide. While the clinical approach to BCa has remained largely unchanged for many years, recent discoveries have paved the way to a new...

  • Review
  • Open Access
3 Citations
2,072 Views
24 Pages

Orchard Soil Health—Current Challenges and Future Perspectives

  • Jiale Huang,
  • Tianhao Wang,
  • Chengshu Xin,
  • Dongyang Wu,
  • Jia Wang,
  • Zhuang Ge and
  • Xin Lou

Globally, orchard soils are facing multiple severe health issues. However, different countries and regions have adopted their own soil classification standards, making many studies only useful for improving soil health in local orchards but not widel...

  • Article
  • Open Access
89 Citations
19,435 Views
29 Pages

Current Challenges and Future Research Directions in Augmented Reality for Education

  • Muhammad Zahid Iqbal,
  • Eleni Mangina and
  • Abraham G. Campbell

The progression and adoption of innovative learning methodologies signify that a respective part of society is open to new technologies and ideas and thus is advancing. The latest innovation in teaching is the use of Augmented Reality (AR). Applicati...

  • Review
  • Open Access
20 Citations
6,461 Views
9 Pages

Zika virus is an emergent pathogen that gained significant importance during the epidemic in South and Central America as unusual and alarming complications of infection were recognized. Although initially considered a self-limited benign infection,...

  • Article
  • Open Access
1,784 Views
5 Pages

Although an electric snowmobile can be constructed, there are several technical challenges to make it viable for end-users. The energy requirements are extremely variable and depend on the weather conditions. Both temperature and snow conditions add...

  • Review
  • Open Access
1,330 Views
21 Pages

2 December 2025

This paper presents a review of current trends and challenges in greywater use in buildings, with particular emphasis on toilet = flushing applications. It discusses the quantitative and qualitative characteristics of greywater, including its generat...

  • Review
  • Open Access
8 Citations
4,862 Views
13 Pages

Current Situations and Challenges in the Development of Health Information Literacy

  • Qiulin Wang,
  • Chunhua Tao,
  • Yuan Yuan,
  • Song Zhang and
  • Jingyan Liang

Health information literacy (HIL) is a significant concept that has gradually become known to the broader public in recent years. Although the definitions of HIL and health literacy seem to overlap, as an independent subconcept, HIL still shows a uni...

  • Review
  • Open Access
58 Citations
14,854 Views
17 Pages

Ebola Virus Disease Vaccines: Development, Current Perspectives & Challenges

  • Sumira Malik,
  • Shristi Kishore,
  • Sagnik Nag,
  • Archna Dhasmana,
  • Subham Preetam,
  • Oishi Mitra,
  • Darwin A. León-Figueroa,
  • Aroop Mohanty,
  • Vijay Kumar Chattu and
  • Ranjit Sah
  • + 2 authors

26 January 2023

The global outgoing outbreaks of Ebola virus disease (EVD) in different regions of Sudan, Uganda, and Western Africa have brought into focus the inadequacies and restrictions of pre-designed vaccines for use in the battle against EVD, which has affir...

  • Review
  • Open Access
16 Citations
7,708 Views
18 Pages

Amyloidoses include a large variety of local and systemic diseases that share the common feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are those directly involved in neurodegenerative diseases, while others...

  • Review
  • Open Access
73 Citations
15,678 Views
36 Pages

Secure Cloud Infrastructure: A Survey on Issues, Current Solutions, and Open Challenges

  • Yara Alghofaili,
  • Albatul Albattah,
  • Noura Alrajeh,
  • Murad A. Rassam and
  • Bander Ali Saleh Al-rimy

27 September 2021

Cloud computing is currently becoming a well-known buzzword in which business titans, such as Microsoft, Amazon, and Google, among others, are at the forefront in developing and providing sophisticated cloud computing systems to their users in a cost...

  • Review
  • Open Access
48 Citations
9,971 Views
14 Pages

12 April 2022

Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressively debilitating, rare disease associated with high mortality. ATTR-CM occurs when TTR amyloid protein builds up in the myocardium along with different organs, most commonly the peripheral...

  • Review
  • Open Access
33 Citations
7,141 Views
15 Pages

21 May 2021

Vitamin D is a micronutrient with pleiotropic effects in humans. Due to sedentary lifestyles and increasing time spent indoors, a growing body of research is revealing that vitamin D deficiency is a global problem. Despite the routine measurement of...

  • Review
  • Open Access
18 Citations
7,664 Views
28 Pages

The Current Challenges for Drug Discovery in CNS Remyelination

  • Sonia Balestri,
  • Alice Del Giovane,
  • Carola Sposato,
  • Marta Ferrarelli and
  • Antonella Ragnini-Wilson

The myelin sheath wraps around axons, allowing saltatory currents to be transmitted along neurons. Several genetic, viral, or environmental factors can damage the central nervous system (CNS) myelin sheath during life. Unless the myelin sheath is rep...

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