Search Results (1,268)

The development of photonic-integrated circuits (PICs) for data communication, sensing, and quantum computing is hindered by the high complexity and cost of traditional fabrication methods, which rely on expensive equipment, limiting accessibility for research and prototyping. This study introduces a Direct Laser Writing (DLW) system designed as a low-cost alternative, utilizing an XY platform for precise substrate movement and an optical system comprising a collimator and lens to focus the laser beam. Operating on a single layer, the system employs SU-8 photoresist to fabricate polymer-based structures on substrates such as ITO-covered glass. Preparation involves thorough cleaning, spin coating with photoresist, and pre- and post-baking to ensure material stability. This approach reduces dependence on costly infrastructure, making it suitable for academic settings and enabling rapid prototyping. A user interface and custom slicer process standard .dxf files into executable commands, enhancing operational flexibility. Experimental results demonstrate a resolution of 10 µm, with successful patterning of structures, including diffraction grids, waveguides, and multimode interference devices. This system aims to transform PIC prototype fabrication into a cost-effective, accessible process. Full article

We report a defect-selective luminescence response in calcium-deficient hydroxyapatite (HAp) induced by electron and ion irradiation. Compacted HAp pellets prepared from hydrothermally grown nanofibers were investigated to analyze defect-related luminescence using photoluminescence (PL) and cathodoluminescence (CL) techniques, both before and after compaction. Low-energy electron beam irradiation (15 keV) produced a two-stage luminescent response, an initial enhancement arising from field-assisted activation of OH-channel vacancies (V_OH and V_OH + H_i), followed by an exponential decay attributed to defect annealing. Monochromatic transient CL measurements show that this rise–decay behavior is selective to the OH-related bands at 2.57 and 2.95 eV, whereas the 3.32 and 3.67 eV emissions exhibit only a monotonic exponential decay. The corresponding decay constants further indicate that the activated OH-channel vacancies anneal more rapidly than the other centers, consistent with their higher electron-capture probability and lower structural stability. In contrast, ${\mathrm{Ga}}^{+}$ ion irradiation (30 keV, 1.4 × 10⁻¹³ A/µm²) induced progressive monotonic luminescence quenching, primarily driven by selective annealing of oxygen vacancies in $\mathrm{P}{\mathrm{O}}_4^{3-}$ groups. These complementary pathways, electron-induced activation and ion-driven suppression, demonstrate that irradiation serves as a versatile tool for defect engineering in hydroxyapatite. Beyond providing fundamental insights into vacancy stability, these results open new routes for tailoring the optical, sensing, and bioimaging functionalities of HAp through controlled irradiation. Full article

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by age-dependent degeneration of dopaminergic neurons in the substantia nigra, a process mediated by α-synuclein aggregation, mitochondrial dysfunction, and impaired proteostasis. While BAP31—an endoplasmic reticulum protein critical for protein trafficking and degradation—has been implicated in neuronal processes, its role in PD pathogenesis remains poorly understood. To investigate the impact of BAP31 deficiency on PD progression, we generated dopamine neuron-specific BAP31 conditional knockout with DAT-Cre (cKO) mice (Slc6a3cre-BAP31^fl/fl) and subjected them to MPTP-lesioned Parkinsonian models. Compared to BAP31^fl/fl controls, Slc6a3cre-BAP31^fl/fl mice exhibited exacerbated motor deficits following MPTP treatment, including impaired rotarod performance, reduced balance beam traversal time, and diminished climbing and voluntary motor capacity abilities. BAP31 conditional deletion showed no baseline phenotype, with deficits emerging only after MPTP. Our results indicate that these behavioral impairments correlated with neuropathological hallmarks: decreased NeuN neuronal counts, elevated GFAP astrogliosis, reduced tyrosine hydroxylase levels in the substantia nigra, and aggravated dopaminergic neurodegeneration. Mechanistically, BAP31 deficiency disrupted mitochondrial homeostasis by suppressing the PINK1–Parkin mitophagy pathway. Further analysis revealed that BAP31 regulates PINK1 transcription via the transcription factor Engrailed Homeobox 1. Collectively, our findings identify BAP31 as a neuroprotective modulator that mitigates PD-associated motor dysfunction by preserving mitochondrial stability, underscoring its therapeutic potential as a target for neurodegenerative disorders. Full article

Optical image stabilization (OIS) is crucial for improving airborne opto-electronic imaging performance under dynamic conditions. This study presents a two-dimensional piezoelectric-driven OIS platform capable of compensating linear image shift errors. A motion platform integrating a bridge amplification mechanism and right-angle guiding beams was developed, and its theoretical model was validated through finite element analysis (FEA). To enhance the platform’s repeatability, the hysteresis of the piezoelectric actuator was described using the Bouc-Wen model, and was optimized using a Hybrid Genetic Algorithm and Particle Swarm Optimization (HGAPSO). Experimental results demonstrated that the platform achieves a workspace of 53.92 μm × 53.76 μm, a motion resolution of 30 nm, a maximum coupling error of 2.28%, and a first-order resonant frequency of 356.69 Hz. A composite controller incorporating HGAPSO attained submicron tracking accuracy, with errors of 0.43 μm and 0.47 μm along the X and Y axes, respectively. Strong agreement among theoretical analysis, FEA, and experimental results confirms the platform’s precision and effectiveness meeting the requirements of the OIS. This work provides valuable guidance for the development of high-frequency OIS systems in highly dynamic operational environments. Full article

Wind-induced response poses a significant challenge to the stability of extra-large-span heavy steel box girders during synchronous lifting operations. This study adopted a method combining numerical simulation with on-site monitoring to investigate the aerodynamic characteristics the beam during the overall hoisting process of the Xiaotun Bridge. A high-fidelity finite element model was established using Midas NFX 2024 R1, and fluid–structure interaction (FSI) analysis was conducted, utilizing the RANS k-ε turbulence model to simulate stochastic wind fields. The results show that during the lifting stage from 3 m to 25 m, the maximum horizontal displacement of the steel box girder rapidly increases at wind angles of 90° and 60°, and the peak displacement is reached at 25 m. Under a strong breeze at a 90° wind angle and 25 m lifting height, the maximum lateral displacement was 42.88 mm based on FSI analysis, which is approximately 50% higher than the 28.58 mm obtained from linear static analysis. Subsequently, during the 25 m to 45 m lifting stage, the displacement gradually decreases and exhibits a linear correlation with lifting height. Concurrently, the maximum stress of the lifting lug of the steel box girder increases rapidly in the 3–25 m lifting stage, reaches the maximum at 25 m, and gradually stabilizes in the 25–45 m lifting stage. The lug stress under the same critical condition reached 190.80 MPa in FSI analysis, compared with 123.83 MPa in static analysis, highlighting a significant dynamic amplification. Furthermore, the detrimental coupling effect between mechanical vibrations from the lifting platform and wind loads was quantified; the anti-overturning stability coefficient was reduced by 10.48% under longitudinal vibration compared with lateral vibration, and a further reduction of up to 39.33% was caused by their synergy with wind excitation. Field monitoring validated the numerical model, with stress discrepancies below 9.7%. Based on these findings, a critical on-site wind speed threshold of 9.38 m/s was proposed, and integrated control methods were implemented to ensure construction safety. During on-site lifting, lifting lug stresses were monitored in real time, and if the predefined threshold was exceeded, contingency measures were immediately activated to ensure a controlled termination. Full article

Flexible photovoltaic (PV) support systems, referring to cable-supported structural systems that carry conventional rigid PV modules rather than flexible thin-film modules, have attracted increasing attention as a promising solution for photovoltaic construction in complex terrains due to their advantages of broad-span design and simplified installation. However, the deformation behavior of flexible PV supports remains insufficiently understood, which restricts its application and engineering optimization. To address this issue, a three-dimensional finite element model of a flexible PV support system was developed using an in-house Python code to investigate its deformation characteristics. The model discretizes the structure into beam and cable elements according to their mechanical properties, and the coupling relationship between their degrees of freedom is established by means of a multi-point constraint. The validation of the proposed model is confirmed by comparison with theoretical solutions. Simulation results reveal that the deformation of flexible PV supports is more sensitive to horizontal loads, indicating that their overall deformation performance is primarily governed by lateral rather than vertical loading. Furthermore, dynamic analyses show that higher loading frequencies induce noticeable torsional de-formation of the structure, which may compromise the stability of the PV panels. These findings provide valuable theoretical guidance for the design and optimization of flexible PV support systems deployed in complex terrains. Full article

To investigate the in situ irradiation effects of gallium nitride at varying temperatures, we combined ion beam-induced luminescence spectroscopy with variable-temperature irradiation using a home-built IBIL system and a GIC4117 2 × 1.7 MV tandem accelerator. Unlike previous static studies—limited to post-irradiation or single-temperature luminescence—we in situ tracked dynamic luminescence changes throughout irradiation, directly capturing the real-time responses of luminescent centers to coupled temperature-dose variations—a rare capability in prior work. To clarify how irradiation and temperature affect the luminescent centers of GaN, we integrated density functional theory (DFT) calculations with literature analysis, then resolved the yellow luminescence band into three emission centers via Gaussian deconvolution: 1.78 eV associated with C/O impurities, 1.94 eV linked to VGa, and 2.2 eV corresponding to CN defects. Using a single-exponential decay model, we further quantified the temperature- and dose-dependent decay rates of these centers under dual-variable temperature and dose conditions. Experimental results show that low-temperature irradiation such as at 100 K suppresses the migration and recombination of V_Ga/C_N point defects, significantly enhancing the radiation tolerance of the 1.94 eV and 2.2 eV emission centers; meanwhile, it reduces non-radiative recombination center density, stabilizing free excitons and donor-bound excitons, thereby improving near-band-edge emission center resistance. Notably, the 1.94 eV emission center linked to gallium vacancies exhibits superior cryogenic radiation tolerance due to slower defect migration and more stable free exciton/donor-bound exciton states. Collectively, these findings reveal a synergistic regulation mechanism of temperature and radiation fluence on defect stability, addressing a key gap in static studies, providing a basis for understanding degradation mechanisms of gallium nitride-based devices under actual operating conditions (coexisting temperature fluctuations and continuous radiation), and offering theoretical/experimental support for optimizing radiation-hardened gallium nitride devices for extreme environments such as space or nuclear applications. Full article

In this study, MIL-88A(Fe)-X (X = 300, 500, 600) was successfully synthesized via electron beam irradiation and employed to activate periodate (PI) for tetracycline (TC) degradation. Experimental results indicated that the optimal irradiation dosage was 300 kGy for MIL-88A(Fe)-X. And 99.0% of TC could be degraded under the optimum reaction conditions (catalyst dosage of 20 mg, PI concentration of 1.0 mM, initial TC concentration of 10 mg/L, pH = 6.8, and temperature of 25 °C) in MIL-88A(Fe)-300/PI system. Furthermore, quenching experiments were conducted to investigate the degradation mechanism, revealing IO₃· and IO₄· radicals played predominant roles in MIL-88A(Fe)-300/PI system. The system exhibited excellent stability and recyclability, maintaining a degradation efficiency of over 90% after three consecutive cycles. This study demonstrated that the MIL-88A(Fe)/PI system achieved rapid degradation and high reproducibility for TC removal. The proposed method could effectively reduce antibiotic residues in the environment, offering a promising strategy for addressing antibiotic pollution. Future work can be conducted to assess its practical application performance under various environmental conditions. Full article

This study comprehensively analyzes the free vibration and transient response for a sandwich piezoelectric laminated beam with elastic boundaries in a thermal environment. Quasi-3D shear deformation beam theory (Q3DBT) and Hamilton’s principle are used to obtain the thermo-electro-mechanical coupling equations, and the method of reverberation-ray matrix (MRRM) is utilized to integrate the phase and scattering relationship of the structure in a unified approach. Specifically, the scattering relationship established by the Mixed Rigid-Rod Model (MRRM) via dual coordinate systems describes the general dynamic model of the beam using generalized displacements and generalized forces at the two endpoints. This analytical solution is compared with the finite element numerical results based on Solid5 and Solid45 elements. The similarity of this approach lies in the fact that solid elements can account for the Poisson effect of thick beams, while the difference is that solid elements have a certain width; here, the error is minimized by adopting a single-element division in the width direction. Comparison of the numerical results under different geometric parameters and boundary conditions with the simulation software proves that MRRM has good accuracy and stability in analyzing the dynamic performance of sandwich piezoelectric laminated beams. On this basis, a spring-supported boundary technology is introduced to expand the flexibility of classical boundary conditions, and a detailed parameterization study is conducted on the material properties of the base layer, including the material parameters, geometric property, and the external temperature. The study in this article provides many new results for sandwich-type piezoelectric laminated structures to help further research. Full article

Maintaining the stability of the mine roadway is of paramount importance, as it is critical in ensuring the daily operational continuity, personnel safety, long-term economic viability, and sustainability of the entire mining operation. Significant instability can trigger serious disruptions—such as production stoppages, equipment damage, and severe safety incidents—which ultimately compromise the project’s financial returns and future prospects. Therefore, the proactive assessment and rigorous control of roadway stability constitute a foundational element of successful and sustainable resource extraction. In China, thick and extra-thick coal seams constitute over 44% of the total recoverable coal reserves. Consequently, their safe and efficient extraction is considered vital in guaranteeing energy security and enhancing the efficiency of resource utilization. The surrounding rock of gob-side roadways in typical coal seams is often fractured due to high ground stress, intensive mining disturbances, and overhanging goaf roofs. Consequently, asymmetric failure patterns such as bolt failure, steel belt tearing, anchor cable fracture, and shoulder corner convergence are common in these entries, which pose a serious threat to mine safety and sustainable mining operations. This deformation and failure process is associated with several parameters, including the coal seam thickness, mining technology, and surrounding rock properties, and can lead to engineering hazards such as roof subsidence, rib spalling, and floor heave. This study proposes countermeasures against asymmetric deformation affecting gob-side entries under intensive mining pressure during the fully mechanized caving of extra-thick coal seams. This research selects the 8110 working face of a representative coal mine as the case study. Through integrated field investigation and engineering analysis, the principal factors governing entry stability are identified, and effective control strategies are subsequently proposed. An elastic foundation beam model is developed, and the corresponding deflection differential equation is formulated. The deflection and stress distributions of the immediate roof beam are thereby determined. A systematic analysis of the asymmetric deformation mechanism and its principal influencing factors is conducted using the control variable method. A support approach employing a mechanical constant-resistance single prop (MCRSP) has been developed and validated through practical application. The findings demonstrate that the frequently observed asymmetric deformation in gob-side entries is primarily induced by the combined effect of the working face’s front abutment pressure and the lateral pressure originating from the neighboring goaf area. It is found that parameters including the immediate roof thickness, roadway span, and its peak stress have a significant influence on entry convergence. Under both primary and secondary mining conditions, the maximum subsidence shows an inverse relationship with the immediate roof thickness, while exhibiting a positive correlation with both the roadway span and the peak stress. Based on the theoretical analysis, an advanced support scheme, which centers on the application of an MCRSP, is designed. Field monitoring data confirm that the peak roof subsidence and two-side closure are successfully limited to 663 mm and 428 mm, respectively. This support method leads to a notable reduction in roof separation and surrounding rock deformation, thereby establishing a theoretical and technical foundation for the green and safe mining of deep extra-thick coal seams. Full article

Background: Orofacial myofunctional therapy (OMT) is an emerging adjunctive treatment for obstructive sleep apnea (OSA), but its effects on upper airway structural support, particularly the hyoid complex, are not well defined. This study assessed the short-term effects of OMT on hyoid bone position and sleep-related indices in adults with mild to moderate OSA. Methods: In this assessor-blinded randomized controlled trial (ClinicalTrials.gov Identifier: NCT06079073), 13 adults with mild to moderate OSA were randomized to a 12-week web-based OMT program (n = 9) or a waitlist control group (n = 4). Cone-beam computed tomography (CBCT) and three-night home sleep testing were performed at baseline and follow-up. The primary outcome was change in axis-based cephalometric hyoid position measures; secondary outcomes included sleep parameters such as the apnea–hypopnea index (AHI). Results: No significant within- or between-group differences were observed in AHI, oxygen desaturation index, or mean nocturnal SpO₂ after 12 weeks (all p > 0.05). However, several cephalometric variables showed significant between-group differences. The waitlist group exhibited greater posterior–inferior hyoid displacement than the OMT group, with large effect sizes across multiple vector measures (all p ≤ 0.045; r = 0.56–0.66). Posterior and inferior hyoid displacement was associated with higher AHI and lower SpO₂, whereas increased lower pharyngeal airway width was associated with lower AHI. Conclusions: Short-term OMT did not improve sleep-disordered breathing indices but was associated with stabilization of hyoid bone position. These findings suggest that structural stabilization may precede functional improvement and highlight the clinical relevance of vector-based hyoid analysis. Full article

Background/Objectives: The aim of this study is to evaluate pretreatment osseous changes in the temporomandibular joint (TMJ) in orthognathic surgery patients using cone-beam computed tomography (CBCT) and to determine the distribution of the findings according to sagittal skeletal malocclusion groups. Methods: CBCT images of 103 patients (206 condyles) were retrospectively analyzed. Patients were classified as Class I, II, and III based on ANB angles. Condylar morphology was assessed for flattening, sclerosis, erosion, osteophyte formation, and subchondral bone cysts. All evaluations were performed by a single investigator (κ = 0.87). Group differences were analyzed using the chi-square test with Bonferroni correction (p < 0.05). Results: The most frequent alteration was flattening (29.6%), followed by sclerosis (11.2%), erosion (10.7%), osteophyte formation (8.3%), and subchondral bone cysts (4.4%). No significant sex-related differences were found (p > 0.05). A significant difference was observed only in sclerosis (p = 0.049), which was more prevalent in Class I than Class III. Flattening predominated in all groups, while erosion and osteophytes were more common in Class II, and sclerosis was more frequent in Class I. Conclusions: This study demonstrated that condylar flattening was the most common morphological alteration in orthognathic patients across all skeletal malocclusion groups. The higher prevalence of sclerosis in Class I compared with Class III suggests that mandibular positioning may influence adaptive and degenerative remodeling processes of the TMJ. This study emphasizes the importance of CBCT evaluation for detecting osseous changes in TMJ before orthognathic surgery and demonstrates that pre-existing alterations may impact surgical stability and postoperative functional outcomes. Full article

The RADFET VT06 developed by Varadis (Cork, Ireland), which is aimed at high-dose applications, mainly for spacecraft missions, has been characterized by low- and high-energy proton beams at two different facilities, the Accelerator National Centre (Sevilla, Spain) and the Paul Scherrer Institute (PSI) located in Villigen (Switzerland), using a reader unit system developed by the University of Granada (Spain). The devices have been characterized with proton energies of 1, 2, 3, 150, and 230 MeV, with accumulated doses from 130 to 512 Gy, where the RADFET was unbiased during the irradiation while the source voltage was measured before and after irradiation to monitor the radiation dose. Excellent linearity has been obtained with a minimum correlation factor R² of 0.996, with a sensitivity that can vary from (0.691 ± 0.007) mV/Gy for 1 MeV to (1.143 ± 0.023) mV/Gy for 230 MeV without any build-up layer. An excellent stability was found in the studied cases, with dispersion being lower than 4% after a dose accumulation higher than 500 and 200 Gy for protons of 1 and 3 MeV, respectively. The detectors demonstrated linear responses, very low sensitivity dispersion per set of samples, and excellent stability after irradiation. This shows that, with an appropriate readout system, the RADFET can become an excellent system for high-dose proton beams. Full article

Additive manufacturing (AM) of titanium alloys enables the production of complex, high-performance components, but the steep thermal gradients and rapid solidification involved make it challenging to control crystallographic texture and phase evolution. This review synthesizes the current understanding of how these thermal conditions influence grain morphology, texture intensity, and solid-state transformations in key alloys such as Ti-6Al-4V (Ti64), Ti-6Al-2Sn-4Zr-2Mo (Ti6242), Ti-5Al-5Mo-5V-3Cr (Ti5553), and metastable β-Ti systems processed by powder bed fusion-based processes (PBF) such as laser powder bed fusion (LPBF) and electron beam powder bed fusion (EBPBF/EBM). Emphasis is placed on mechanisms governing epitaxial columnar β-grain growth, α′ martensite formation, and the development of heterogeneous α/β distributions. The impact of processing variables on texture development and transformation kinetics is critically examined, alongside phase fractions. Across studies, AM-induced textures are consistently linked to mechanical anisotropy, with performance strongly dependent on build direction and alloy chemistry. Post-processing strategies, including tailored heat treatments and hot isostatic pressing (HIP), show clear potential to modify grain structure, reduce texture intensity, and stabilize desirable phase balances in titanium alloys. These insights highlight the emerging ability to deliberately engineer microstructures for reliable, application-specific properties in powder-based AM titanium alloys. Full article

The mechanical performance of rail fasteners plays a crucial role in the track–structure interaction of high-speed railways. A reasonable lateral stiffness of the fastener system can enhance the stability and safety of train operation and prevent derailment accidents. Under seismic action, adjacent bridge spans undergo reciprocating displacement, causing the rail-fastener system near the beam ends to be subjected to lateral cyclic forces. To investigate the mechanical and deformation behavior of the WJ-8B fastener system under lateral loading, low-cycle reciprocating loading tests were conducted on the rail-fastener system considering different bolt torques. The load–displacement curves and torque–rotation curves of the fastener system were obtained, and formulas for calculating the characteristic values of the mechanical properties of the WJ-8B fastener system were fitted, which show good agreement with the experimental results. The results indicate that the lateral mechanical behavior of the WJ-8B fastener exhibits significant nonlinear characteristics, marked by three distinct inflection points in the load–displacement curve that delineate five stages: initial stage, rail shearing stage, rail sliding stage, rail contact stage, and three-point contact. The bolt torque is positively correlated with the lateral stiffness of the fastener system. Increasing the torque from 115 N·m to 190 N·m enhances the lateral bearing capacity by 29.06% in the push direction and by 38.74% in the pull direction. Meanwhile, the system torque decreases by 21.45% in the push direction and increases by 21.14% in the pull direction. Full article