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Article

58 Citations

13,213 Views

13 Pages

Evaluation of the Activity of the Sponge Metabolites Avarol and Avarone and their Synthetic Derivatives Against Fouling Micro- and Macroorganisms

Maria Tsoukatou,
Jean Philippe Maréchal,
Claire Hellio,
Irena Novaković,
Srdan Tufegdzic,
Dusan Sladić,
Miroslav J Gašić,
Anthony S Clare,
Constantinos Vagias and
Vassilios Roussis

Molecules2007, 12(5), 1022-1034;https://doi.org/10.3390/12051022

15 May 2007

The sesquiterpene hydroquinone avarol (1) was isolated from the marine sponge Dysidea avara, whereas the corresponding quinone, avarone (2), was obtained by oxidation of avarol, and the significantly more lipophilic compounds [3’-(p-chloro-phenyl)ava...

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Article

26 Citations

5,129 Views

22 Pages

Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced Form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone

Concetta Imperatore,
Roberto Gimmelli,
Marco Persico,
Marcello Casertano,
Alessandra Guidi,
Fulvio Saccoccia,
Giovina Ruberti,
Paolo Luciano,
Anna Aiello and
Marialuisa Menna
+ 4 authors

Mar. Drugs2020, 18(2), 112;https://doi.org/10.3390/md18020112

14 February 2020

The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistos...

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Article

13 Citations

3,392 Views

24 Pages

Evidence of Insulin-Sensitizing and Mimetic Activity of the Sesquiterpene Quinone Avarone, a Protein Tyrosine Phosphatase 1B and Aldose Reductase Dual Targeting Agent from the Marine Sponge Dysidea avara

Marcello Casertano,
Massimo Genovese,
Alice Santi,
Erica Pranzini,
Francesco Balestri,
Lucia Piazza,
Antonella Del Corso,
Sibel Avunduk,
Concetta Imperatore and
Paolo Paoli
+ 1 author

Pharmaceutics2023, 15(2), 528;https://doi.org/10.3390/pharmaceutics15020528

4 February 2023

Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. First-line therapeutic options for T2DM treatment are monodrug therapies, often replaced by multidrug therapies to...

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Review

113 Citations

15,190 Views

22 Pages

Cytotoxic Terpene Quinones from Marine Sponges

Marina Gordaliza

Mar. Drugs2010, 8(12), 2849-2870;https://doi.org/10.3390/md8122849

24 November 2010

The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural...

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