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Article

1,700 Views

12 Pages

Stimulation of Angiotensin II Receptor Subtype 2 Reduces Preeclampsia-like Symptoms in a Mouse Model of Preeclampsia

Keiichi Matsubara,
Yuko Matsubara,
Yuka Uchikura and
Takashi Sugiyama

Curr. Issues Mol. Biol.2024, 46(9), 9760-9771;https://doi.org/10.3390/cimb46090579

2 September 2024

Angiotensin II (AngII) receptor subtype 1 (AT1R) is involved in the pathogenesis of preeclampsia (PE). Angiotensin II receptor subtype 2 (AT2R) can antagonize the effects of AT1R, but its effects during pregnancy are not known. We investigated the ef...

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Article

7 Citations

2,643 Views

12 Pages

Evidence of Renin–Angiotensin System Receptors in Deep Fascia: A Role in Extracellular Matrix Remodeling and Fibrogenesis?

Carmelo Pirri,
Brasilina Caroccia,
Andrea Angelini,
Lucia Petrelli,
Maria Piazza,
Carlo Biz,
Pietro Ruggieri,
Raffaele De Caro and
Carla Stecco

Biomedicines2022, 10(10), 2608;https://doi.org/10.3390/biomedicines10102608

17 October 2022

Recent studies have shown that fascial fibroblasts are sensitive to different stimuli (biochemical or biophysical), promoting extracellular matrix remodeling, as well as synthetic activity. Moreover, the extensive literature on the renin–angiot...

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Article

8 Citations

2,464 Views

18 Pages

Effects of Renal Denervation on the Enhanced Renal Vascular Responsiveness to Angiotensin II in High-Output Heart Failure: Angiotensin II Receptor Binding Assessment and Functional Studies in Ren-2 Transgenic Hypertensive Rats

Zuzana Honetschlägerová,
Lucie Hejnová,
Jiří Novotný,
Aleš Marek and
Luděk Červenka

Biomedicines2021, 9(12), 1803;https://doi.org/10.3390/biomedicines9121803

30 November 2021

Detailed mechanism(s) of the beneficial effects of renal denervation (RDN) on the course of heart failure (HF) remain unclear. The study aimed to evaluate renal vascular responsiveness to angiotensin II (ANG II) and to characterize ANG II type 1 (AT1...

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Article

742 Views

16 Pages

Comparative Histopathological Evaluation of Pulmonary Arterial Remodeling in Fatal COVID-19 and H1N1 Influenza Autopsy Cases

Sergiy G. Gychka,
Sofiia I. Nikolaienko,
Nataliia V. Shults,
Volodymyr M. Vasylyk,
Bohdan O. Pasichnyk,
Iryna V. Kagan,
Yulia V. Dibrova,
Muin Tuffaha and
Yuichiro J. Suzuki

COVID2025, 5(6), 79;https://doi.org/10.3390/covid5060079

28 May 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic that devastated the world. While this is a respiratory virus, one feature of the SARS-CoV-2 infection was recognized to cause pathoge...

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