Search Results (427)

Phacelia tanacetifolia Benth. is a species of annual plant that has been gaining importance in recent years. Initially, it was treated as an ornamental plant and valuable only to bees. Over the years, this species has become more widely known, and many more of its advantages have been discovered. The aim of this study was to learn about the contemporary economic importance of Phacelia tanacetifolia Benth. The extraordinary, rapid increase in the plant’s biomass means that it is valued as a fodder plant and at the same time is included in the group of leaders among catch crops. It is characterized by low requirements for soil quality. The main advantage of this plant is its high resistance to drought and frost. A great advantage of this plant is its high drought resistance. It is recommended for sowing both in monoculture and in mixtures with other species. In the light of current standards and assumptions, it fits perfectly into the framework of sustainable development. It is a valuable link in the biodiversity chain, as well as support for a number of ecosystem services such as CO₂ sequestration, retention of nutrients in the soil or protection of its structure. Phacelia is seen as having great potential as a plant that provides food for a number of pollinators. The latest research also focuses on assessing the possibility of using it for energy purposes (biogas). Efforts are being made to introduce phacelia on a wider scale to eliminate crop monocultures and significantly strengthen biodiversity in a given area. Phacelia plays an important role in various agronomic systems and effectively supports the protection of the natural environment. The contribution of this species to the development of ecosystem services to date is undeniable. It should be assumed that this plant will continue to significantly support a number of activities for sustainable development. Full article

Objectives: The primary objective of this study was to determine whether motor disorders are significantly more prevalent in children with Autism Spectrum Disorder (ASD) without co-occurring genetic or neurological conditions compared to neurotypical children. Another aim was to explore the applicability of the MABC-2 test for assessing motor skills in a Polish cohort of children with ASD. Additionally, this study sought to develop a basic framework for motor skill assessment in children with autism. Methods: This study included 166 Caucasian children, both sexes, aged 5–12 years, without intellectual disability (IQ ≥ 70), without concomitant genetic or neurological disorders, particularly epilepsy or cerebral palsy. The study group consisted of children with ASD (n = 71), and the control group consisted of neurotypical children (n = 95). The participants were assessed with the Movement Assessment Battery for Children–second edition (MABC-2), MABC-2 checklist and the Developmental Coordination Disorder Questionnaire (DCDQ), used as a reference point. Results: The children with ASD obtained significantly lower MABC-2 test results in all subtests in comparison with the control group. The children with suspected or diagnosed coordination disorders were characterized by a significantly greater number of co-occurring non-motor factors than the other participants of this study. MABC-2 test showed greater consistency with DCDQ than with the MABC-2 questionnaire. Conclusions: Children with ASD present a lower level of manual dexterity and balance and greater difficulties in performing tasks, including throwing and catching, in comparison with neurotypical children. The MABC-2 test with the MABC-2 checklist and DCDQ questionnaire constitute a complementary diagnostic tool. Full article

The evaluation of climate change effects on airport infrastructures is important to maintain safety and flexibility in air travel operations. Airports are particularly vulnerable to extreme weather events and temperature fluctuations, which can disrupt operations, compromise passenger safety, and cause economic losses. Issues such as flooded runways and the disruption of power supplies highlight the need for strong adaptation strategies. The study focuses on the application of the high-resolution regional model COSMO-CLM to assess climate change impacts on Roma Fiumicino airport (Italy) under the IPCC RCP8.5 scenario. The complex topography of Italy requires fine-scale simulation to catch localized climate dynamics. By employing advanced statistical methods, such as fractal analysis, this research aims to increase an understanding of climate change and improve the model prediction capability. The findings provide valuable insights for designing resilient airport infrastructures and updating operational protocols in view of evolving climate risks. A consistent increase in daily temperatures is projected, along with a modest positive trend in annual precipitation. The use of advanced statistical methods revealed insights into the fractal dimensions and frequency components of climate variables, showing an increasing complexity and variability of future climatic patterns. Full article

Background/Objectives: Adult vaccination remains suboptimal, particularly among older adults and individuals with chronic conditions. Hospitals represent a strategic setting for improving vaccination coverage among these high-risk populations. This systematic review and meta-analysis evaluated hospital-based interventions aimed at enhancing vaccine uptake in adults aged ≥60 years or 18–64 years with at-risk medical conditions. Methods: We conducted a systematic review and meta-analysis following PRISMA and MOOSE guidelines. Searches in PubMed, EMBASE, and Scopus identified studies published in the last 10 years evaluating hospital-based interventions reporting vaccination uptake. The risk of bias was assessed using validated tools (NOS, RoB 2, ROBINS-I, QI-MQCS). A meta-analysis was conducted for categories with ≥3 eligible studies reporting pre- and post-intervention vaccination coverage in the same population. Results: We included 44 studies. Multi-component strategies (n = 21) showed the most consistent results (e.g., pneumococcal uptake from 2.2% to 43.4%, p < 0.001). Reminder-based interventions (n = 4) achieved influenza coverage increases from 31.0% to 68.0% and a COVID-19 booster uptake boost of +38% after SMS reminders. Educational strategies (n = 11) varied in effectiveness, with one study reporting influenza coverage rising from 1.6% to 12.2% (+662.5%, OR 8.86, p < 0.01). Standing order protocols increased pneumococcal vaccination from 10% to 60% in high-risk adults. Hospital-based catch-up programs improved DTaP-IPV uptake from 56.2% to 80.8% (p < 0.001). For patient education, the pooled OR was 2.11 (95% CI: 1.96–2.27; p < 0.001, I² = 97.2%) under a fixed-effects model, and 2.47 (95% CI: 1.53–3.98; p < 0.001) under a random-effects model. For multi-component strategies, the OR was 2.39 (95% CI: 2.33–2.44; p < 0.001, I² = 98.0%) with fixed effects, and 3.12 (95% CI: 2.49–3.92; p < 0.001) with random effects. No publication bias was detected. Conclusions: Hospital-based interventions, particularly those using multi-component approaches, effectively improve vaccine coverage in older and high-risk adults. Embedding vaccination into routine hospital care offers a scalable opportunity to reduce disparities and enhance population-level protection. Future policies should prioritize the institutional integration of such strategies to support healthy aging and vaccine equity. Full article

Introduction: In 2008, Mexico initiated its national HPV vaccination program targeting adolescent girls. This study aims to evaluate the current status of the program, analyzing trends in vaccine acquisition, administration, and coverage over a 16-year period. Materials and Methods: A retrospective longitudinal study was conducted using secondary data from 2008 to 2023. Official records from three major public health institutions—IMSS, ISSSTE, and SSA—were reviewed to assess HPV vaccine procurement and administration. Results: Significant fluctuations were identified in the number of doses acquired, administered, and the corresponding coverage rates. A marked decline was observed between 2019 and 2021, followed by a sharp increase in 2022 and 2023. Over the entire period, an estimated 6.8 million doses were not administered to the intended target population. Furthermore, 2.6 million doses were administered in excess of the number officially acquired, indicating possible discrepancies in data reporting or vaccine inventory management. Discussion: The findings revealed substantial inconsistencies in vaccine procurement, administration, and coverage across institutions. While IMSS and ISSSTE consistently reported coverage below the theoretical target, SSA occasionally exceeded expectations, potentially compensating for deficits elsewhere. Nevertheless, national coverage remained inadequate in several years, with notable disparities between institutions. These gaps highlight systemic weaknesses in program coordination, planning, and data transparency, contributing to millions of unvaccinated individuals. Conclusions: This study offers a comprehensive analysis of Mexico’s HPV vaccination program, uncovering critical irregularities in its implementation. Challenges include inaccurate target population estimation, inconsistencies between vaccine acquisition and administration, and limited data reliability. Despite some progress in recent years, particularly in the post-pandemic years, the program requires urgent restructuring. This includes implementing a national catch-up strategy, expanding vaccine eligibility, and strengthening surveillance systems to ensure equitable and effective coverage toward the elimination of cervical cancer. Full article

We have previously shown a difference between the gut microbiota composition of stunted and non-stunted children in East Nusa Tenggara, Indonesia. The current study aimed to perform an intervention with a probiotic, Lactiplantibacillus plantarum IS-10506, and its UHT-treated postbiotic compared to placebo in order to accomplish catch-up growth in the stunted children, possibly through modulation of the gut microbiota. Apart from the maltodextrin (placebo), probiotic, and postbiotic in chocolate milk, all groups also received a functional and nutritional biscuit and had access to newly constructed water wells as well as soap to improve hygiene. The results show that independent of treatment, the stunted children had a significantly higher increase in height and zlen (corrected for age) compared with their age- and gender-matched controls but a significantly lower increase in weight. Several potential pathogenic taxa declined in all groups, among which was Escherichia/Shigella (adjusted.p = 6.44 × 10⁻¹⁵), but so did some beneficial taxa, such as Bifidobacterium and Akkermansia. Faecalibacterium, which was already higher in the stunted children at baseline, increased independent of treatment. Changes in the relative abundance of several taxa of the microbiota correlated with the changes in anthropometric measures. In conclusion, although there was no difference between the interventions, understanding the dynamics and the role of the gut microbiota in this process might allow healthcare providers to develop targeted nutritional strategies aimed at optimizing health outcomes for children at risk of stunting, thereby addressing a critical global health issue. Full article

The aim of this research was to clarify the concept of vulnerable micro-enterprises (MEs) and develop a set of indicators for identifying and analyzing developments in vulnerable MEs in “catching up” economies in the context of the regulation on the Social Climate Fund (SCF). The case of Lithuania is studied. A retrospective analysis of business structure research indicators during the period from 2010 to 2023 was carried out. The method of the median was applied to determine thresholds of indicators above (below) which a ME is considered vulnerable. Absolute and relative business structure research indicators were calculated to provide estimates of the number of vulnerable MEs and reveal their role in the economy. The results revealed the number and share of vulnerable MEs which experienced high fuel expenditure (above the median (1M), 1.5M, or 2M). Historically, these MEs created a share of added value and provided employment opportunities. The share was found to vary in accordance with economic activity and the Lithuanian municipality, suggesting that the distribution of financing from the SCF should consider aspects of economic activity and regionality. A number of MEs had an essential share of fuel expenditure in their total operating costs. Vulnerable MEs demonstrate low or negative profitability, and may be insolvent; therefore, they cannot invest in building renovation or environmentally friendly transport. Thus, the research results indicate the need for discussions regarding financing vulnerable MEs in Lithuania. Full article

Ground beetles (Coleoptera, Carabidae) are common predators found in agricultural ecosystems. They feed on crop pests and help reduce pest population. Additionally, they are used as bioindicators to determine the impact of human activities on entomofauna and habitat conditions. The aim of this study was to investigate the ground beetles that inhabit chemically protected (CP) and non-chemically protected (NCP) potato crops and to assess the impact of pesticide use on these beneficial insects. This study was conducted in Poland, on potato fields where ground beetles were caught during four-year crop rotation cycles in 2004, 2008, 2012, and 2016. Two fields with potato crops were chosen: one without chemical protection and the other with chemical protection. Soil traps were used to catch insects, resulting in 7095 individuals of Carabidae, belonging to 41 species, caught throughout the study. The abundance and species richness of ground beetles fluctuated depending on the year of the study and the type of crop protection. Results showed that pesticide use in potato crops decreased ground beetle abundance while species richness remained unaffected. Furthermore, the use of chemical plant protection (CP) induced changes in some life traits of the carabids, leading to a decrease in the abundance of hemizoophages and autumn-breeding carabids. The abundance of the other ecological groups of Carabidae was also year-dependent. Full article

The dynamic nature of infectious diseases introduces inherent challenges to the design of vaccine clinical trials, which consequently makes vaccine indirect treatment comparisons (ITCs) and meta-analyses (MAs) more challenging compared with regular pharmaceuticals. However, comparisons of efficacy and safety between vaccines are being frequently required in vaccine decision making due to a low number of head-to-head clinical trials in the vaccine landscape. The introduction of the European Union Health Technology Assessment (HTA) Regulation (EU HTAR) aims to harmonize HTA efforts across Europe. However, the EU HTAR could also escalate existing challenges for conducting vaccine MAs and ITCs. Such challenges include generating efficacy evidence in time for Joint Clinical Assessment (JCA), incorporating high levels of heterogeneity due to infectious disease-specific characteristics, and tackling a high number of PICOs per submission—likely driven by heterogeneity in the available data and differences in national vaccine calendars. Opportunities to tackle these challenges include introducing a stepwise approach to vaccine assessment in JCA, best-practice recommendations for conducting/interpreting vaccine MAs and ITCs, and condensing the number of PICOs to create larger ‘catch-all’ ITC networks. This perspective article explores these challenges and opportunities further. Full article

Cricket is a dynamic sport, making the selection of key performance indicators (KPIs) challenging. Objective: The study aims to identify KPIs in Twenty-20 (T20) cricket affecting match outcomes. Methods: Cricket performance data was analysed from three seasons of male T20 matches, identifying 136 performance indicators (PIs). The random forest algorithm and lasso logistic regression were used to develop a model to predict match outcomes. Results: The hybrid model achieved 85.9% accuracy with leave-one-out cross-validation statistical analyses. Sixteen KPIs were identified and ranked by importance including wickets lost in the last six overs, two or more wickets in the second innings, run rate in the last six overs, wickets by seam and spin bowling, batting strike rate, singles percentage in the second innings, sixes in the first innings, overs bowled by seam, runs in last six overs, sixes in middle overs, total catches in second innings, dot ball percentage, opening partnership runs, dot balls in the opening six, and singles in the last six. Conclusions: Cricket match performance in the final overs, especially bowling strike rate and scoring runs, were crucial for successful match outcomes. These KPIs offer insights into team strategy, player selection, and match performance evaluation in T20 cricket. Full article

The Bay of Bengal (BoB) is a global hub for marine elasmobranchs, particularly sharks and rays. These apex predators maintain and structure the balanced marine ecosystem and food webs. Marine elasmobranchs in Bangladesh are under-researched and under-managed, and face threats such as habitat degradation, global warming, pollution, illegal fishing, and overexploitation. This study aimed to evaluate the stock status of marine elasmobranches in the Bay of Bengal (BoB), Bangladesh. This research used catch and effort (CE) data for a period of 21 years (2002–2022). Both the Monte Carlo CMSY and BSM models were applied to assess biomass, exploitation rates, and sustainable yields. The BSM estimated a maximum carrying capacity (k) of 134,000 mt, which is larger than the CMSY estimate of 119,000 mt. The estimated intrinsic annual growth (r) from CMSY was 0.282. The MSY values ranged from 5110 mt (BSM) to 8420 mt (CMSY), with BSM indicating overexploitation, as the 2022 catch (7017 mt) exceeded the BSM-derived MSY. Both models suggested depleted and overfishing stock conditions, with B/B_MSY ratios < 1.0 and F/F_MSY ratios > 1.0. Effective management is crucial to prevent overfishing and ensure sustainable practices. Elasmobranch catches must be kept below the BSM-estimated maximum sustainable yield (MSY) of 5110 metric tons with fishing pressure maintained at or below F/F_MSY = 1.0. It is vital to regulate illegal and unlicensed fishing activities. Because of the aggregation of CE data, the results should be interpreted cautiously and never serve as a substitute for species-level assessments. Full article

Wine markets have deeply changed in recent decades in many regards. In particular, wine trade patterns have been deeply reshaped, and this also affects traditional EU exporters, who operate in a more competitive environment, with new players challenging their position and forcing them to readjust their strategies. This study analyzes recent trends in the wine exports of major EU producers. Its goal is to contribute to assessing to what extent their positioning in the international wine markets differs, and to understand the kind of competition they engage in within destination markets, with a focus on the role of their export quality as a major competitive advantage. This analysis only looks at bottled wines, both still and sparkling. It combines the use of traditional trade indicators—such as export quotas, penetration rates, and the average unit value of exports (AUV) with an innovative indicator, called C-Consy, aimed at measuring the sophistication levels of the destination markets. The results show that EU competitors behave in different ways and move along different paths. Some of them show an increasing ability to sell their products in higher segments of sophisticated markets. Others are also quite well positioned in the global arena, but they are fighting to fully catch up with the increasing demand for more sophisticated products from their clients. Some have managed to improve quality and hence advance to higher market segments, while others have shown greater weakness in facing global competition. Looking at typologies, exporters do not always show the same positioning and trends for still and sparkling wines. Full article

Canning is an excellent solution to provide convenient, affordable, nutritious, and safe seafood with a long shelf life. However, many canned products use tuna, sardines, and Atlantic chub mackerel, species that raise sustainability concerns and whose overuse can put additional pressure on them. Hence, this study aimed to i) develop and assess a nutritious and sustainable canned meal prototype using the Atlantic horse mackerel (Trachurus trachurus) (whose EU allowable-catch amounts have increased, particularly, in Iberian waters) and vegetables in light brine in terms of stability, sterility, and physicochemical and sensory properties over a 4-month period at room temperature and ii) evaluate its nutritional contribution for different population groups. After preparation, the meal was stored for one month at ≈20 °C and ≈40 °C (to simulate the 4 months). Although the pH was not stable, the meal was considered commercially sterile according to the challenge accelerated tests. Moreover, aging did not significantly affect the meal’s physicochemical and sensory properties. This innovative meal prototype can be claimed to be “low-fat”, “reduced in NaCl/Na”, a “source of protein, phosphorus, iron, selenium and vitamin D”, and “high in vitamin B12”. It proved to be both nutritious and appealing for consumption, with potential to be scaled up. Full article

Background: Given the significant impact of population immunity on the measles epidemic, understanding immunity differences among populations with varying immunity backgrounds is necessary for identifying immunity gaps and informing vaccination policies. In this study, we aimed to determine the distinct dynamics of vaccine-induced and naturally acquired antibodies, with specific focus on difference in vaccine-induced antibody responses across different birth cohorts. Methods: Based on two cohorts and one cross-sectional study conducted in Anhua County, Hunan Province, China, serum samples from children who followed China’s routine measles vaccination schedule (i.e., two-dose schedule at 8/18 months) and adults who acquired immunity through natural infection were tested for measles IgG antibodies using an enzyme-linked immunosorbent assay. The generalized additive mixed model and a mechanistic model were employed to describe antibody dynamics following vaccination and infections. Wavelet analysis was used to investigate the temporal relationship between the measles epidemic and long-term antibody levels after natural infection. Results: A total of 408 children (0–12 years) and 222 adults (54–84 years) were included in the present study. Vaccine-induced antibody levels following 8 m/18 m vaccination were estimated to fall below the protective threshold of 200 mIU/mL by age of 15.8, whereas antibody levels following infections remained high. The decay rate of vaccine-induced antibodies was estimated at 3.0 × 10⁻³ log-log mIU/mL per year, whereas naturally acquired measles antibodies persisted lifelong with a significantly lower decay rate of 2.30 × 10⁻⁵ log-log mIU/mL per year. Moreover, vaccine-induced antibody levels in children born after 2010—a period of low measles incidence—declined more rapidly (duration of protective immunity: 12.5 years), compared to those born before 2010. Discussion: Our findings revealed immunity heterogeneity among individuals with difference measles immunity backgrounds. In particular, the birth-cohort specific differences in vaccine-induced immunity highlighted the key role of young generations born in settings with low measles incidence in contributing to population immunity gaps. This underlines that greater attention should be given to this group in future catch-up vaccination efforts. Full article

Objective: Malnutrition remains a global challenge to child development, with urban slums in India experiencing high rates of protein deficiency. This study aimed to evaluate the effectiveness of a low-cost, fish bycatch-derived protein supplement in supporting catch-up growth among malnourished children. Methods: Using the Sustainable Community Partnership and Empowerment (SCOPE) model, we implemented a 90-day intervention with daily 10 g of Advanced Protein Powder (APP), produced from underutilized fish bycatch. Forty-six malnourished children (aged 3–6) from Bengaluru slums were randomized into a Control group receiving caloric support or an APP supplement group. Growth indicators, cognition, and caregiver perspectives were assessed. Results: Children receiving the APP supplement showed a significant increase in the weight-for-age percentile (underweight), rising by 7.59%, compared to 0.59% in the Control group (p = 0.02185). Muscle growth, measured by mid-upper arm circumference, also improved significantly in the APP Group (p < 0.05). In the first month, APP supplementation led to a significant height gain of 1.86 cm (p < 0.001), whereas the Control group showed no change (p > 0.05). Additionally, APP supplementation enhanced cognitive function, visual processing, short-term memory, and planning ability, with sustained effects at six months (p < 0.05). Caregivers reported noticeable improvements in children’s vitality, appetite, focus, and engagement in social and learning activities. Conclusions: Bycatch-derived protein supplementation, implemented through the SCOPE model, enhanced physical growth, behavior, and cognition in malnourished children in urban slums. Future studies should investigate the long-term effects, scalability, and adaptability of this sustainable solution for addressing child malnutrition. Full article