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Article

9 Citations

3,313 Views

16 Pages

Morin Disrupts Cytoskeleton Reorganization in Osteoclasts through an ROS/SHP1/c-Src Axis and Grants Protection from LPS-Induced Bone Loss

Hyun-Jung Park,
Jung-Nam Park,
Sun-Young Yoon,
Rina Yu,
Jae-Hee Suh and
Hye-Seon Choi

Antioxidants2022, 11(5), 963;https://doi.org/10.3390/antiox11050963

12 May 2022

Morin is a naturally occurring flavonoid with anti-inflammatory and antioxidative properties. Therefore, we hypothesized that morin may prevent inflammatory bone loss by reducing oxidative stress. To investigate the effect of morin on inflammatory bo...

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Review

13 Citations

5,960 Views

17 Pages

Consideration of SHP-1 as a Molecular Target for Tumor Therapy

Seyeon Lim,
Ki Won Lee,
Jeong Yoon Kim and
Kwang Dong Kim

Int. J. Mol. Sci.2024, 25(1), 331;https://doi.org/10.3390/ijms25010331

26 December 2023

Abnormal activation of receptor tyrosine kinases (RTKs) contributes to tumorigenesis, while protein tyrosine phosphatases (PTPs) contribute to tumor control. One of the most representative PTPs is Src homology region 2 (SH2) domain-containing phospha...

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Review

32 Citations

10,551 Views

28 Pages

Beyond the Cell Surface: Targeting Intracellular Negative Regulators to Enhance T cell Anti-Tumor Activity

Poojitha Sitaram,
Bradley Uyemura,
Subramaniam Malarkannan and
Matthew J. Riese

Int. J. Mol. Sci.2019, 20(23), 5821;https://doi.org/10.3390/ijms20235821

20 November 2019

It is well established that extracellular proteins that negatively regulate T cell function, such as Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4) and Programmed Cell Death protein 1 (PD-1), can be effectively targeted to enhance cancer immuno...

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Article

3 Citations

2,239 Views

17 Pages

Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity

Spike Murphy Müller,
Nina Nelson and
Manfred Jücker

Biomolecules2025, 15(1), 105;https://doi.org/10.3390/biom15010105

10 January 2025

The Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a multidomain protein consisting of two protein–protein interaction domains, the Src homology 2 (SH2) domain, and the proline-rich region (PRR), as well as three phosphoin...

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Article

41 Citations

5,709 Views

18 Pages

SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma

Chao-Yuan Huang,
Li-Ju Chen,
Grace Chen,
Tzu-I Chao and
Cheng-Yi Wang

Int. J. Mol. Sci.2022, 23(19), 11092;https://doi.org/10.3390/ijms231911092

21 September 2022

Ferroptosis is a type of iron-dependent cell death pertaining to an excess of lipid peroxidation. It has been suggested that sorafenib—an anti-angiogenic medication for hepatocellular carcinoma (HCC)—induces ferroptosis, but the underlyin...

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