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Article

3,624 Views

21 Pages

Ras, TrkB, and ShcA Protein Expression Patterns in Pediatric Brain Tumors

Monika Prill,
Agnieszka Karkucinska-Wieckowska,
Magdalena Lebiedzinska-Arciszewska,
Giampaolo Morciano,
Agata Charzynska,
Michal Dabrowski,
Maciej Pronicki,
Paolo Pinton,
Wieslawa Grajkowska and
Mariusz R. Wieckowski

J. Clin. Med.2021, 10(10), 2219;https://doi.org/10.3390/jcm10102219

20 May 2021

Numerous papers have reported altered expression patterns of Ras and/or ShcA proteins in different types of cancers. Their level can be potentially associated with oncogenic processes. We analyzed samples of pediatric brain tumors reflecting differen...

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Article

6 Citations

12,801 Views

12 Pages

Increased Level of Phosphorylated ShcA Measured by Chemiluminescence-Linked Immunoassay Is a Predictor of Good Prognosis in Primary Breast Cancer Expressing Low Levels of Estrogen Receptor

Jonas Cicenas,
Willy Küng,
Urs Eppenberger and
Serenella Eppenberger-Castori

Cancers2010, 2(1), 153-164;https://doi.org/10.3390/cancers2010153

12 March 2010

The SH2 domain-containing adaptor protein ShcA is a proto-oncogene involved in growth factor receptor signaling. The role of phosphorylated ShcA is to link receptor tyrosine kinases with the SH2-containing adaptor protein Grb2, thus facilitating sign...

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Article

1 Citations

2,603 Views

15 Pages

P66Shc (Shc1) Zebrafish Mutant Line as a Platform for Testing Decreased Reactive Oxygen Species in Pathology

Landon Haslem,
Jennifer M. Hays,
Xin A. Zhang and
Franklin A. Hays

J. Cardiovasc. Dev. Dis.2022, 9(11), 385;https://doi.org/10.3390/jcdd9110385

9 November 2022

Reactive oxygen species (ROS) dysregulation exacerbates many pathologies but must remain within normal ranges to maintain cell function. Since ROS-mediated pathology and routine cell function are coupled, in vivo models evaluating low-ROS background...

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Review

24 Citations

5,533 Views

41 Pages

p66Shc in Cardiovascular Pathology

Landon Haslem,
Jennifer M. Hays and
Franklin A. Hays

Cells2022, 11(11), 1855;https://doi.org/10.3390/cells11111855

6 June 2022

p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc’s connections to reactive oxygen species, expression, localization, and...

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Communication

5 Citations

2,270 Views

18 Pages

Distribution of the p66Shc Adaptor Protein Among Mitochondrial and Mitochondria—Associated Membranes Fractions in Normal and Oxidative Stress Conditions

Magdalena Lebiedzinska-Arciszewska,
Barbara Pakula,
Massimo Bonora,
Sonia Missiroli,
Yaiza Potes,
Patrycja Jakubek-Olszewska,
Ines C. M. Simoes,
Paolo Pinton and
Mariusz R. Wieckowski

Int. J. Mol. Sci.2024, 25(23), 12835;https://doi.org/10.3390/ijms252312835

29 November 2024

p66Shc is an adaptor protein and one of the cellular fate regulators since it modulates mitogenic signaling pathways, mitochondrial function, and reactive oxygen species (ROS) production. p66Shc is localized mostly in the cytosol and endoplasmic reti...

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Case Report

16 Citations

7,354 Views

13 Pages

Effect of Feeding a High Calcium: Phosphorus Ratio, Phosphorous Deficient Diet on Hypophosphatemic Rickets Onset in Broilers

Lei Xu,
Ning Li,
Yuhua Z. Farnell,
Xiaoli Wan,
Haiming Yang,
Xiangqian Zhong and
Morgan B. Farnell

Agriculture2021, 11(10), 955;https://doi.org/10.3390/agriculture11100955

1 October 2021

Recently, a P-deficient diet caused rickets in commercial chicks within three days. This study aimed to investigate the duration of onset of rickets in chicks. Data were collected from 3–11 day old chicks raised on 88 commercial farms. Male day-old A...

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