Search Results (31)

This study focuses on the numerical analysis of a centrifugal pump’s suction capability, aiming to reliably predict its suction performance characteristics. The main emphasis of the research was placed on the influence of different turbulence models, the quality of the computational mesh, and the comparison between steady-state and unsteady numerical approaches. The results indicate that steady-state simulations provide an unreliable description of cavitation development, especially at lower flow rates where strong local pressure fluctuations are present. The unsteady k–ω SST model provides the best overall agreement with experimental NPSH₃ characteristics, as confirmed by the lowest mean deviation (within the ISO 9906 tolerance band, corresponding to an overall uncertainty of ±5.5%) and by multiple operating points falling entirely within this range. This represents one of the first detailed unsteady CFD verifications of NPSH prediction in centrifugal pumps operating at high rotational speeds (above 2900 rpm), achieving a mean deviation below ±5.5% and demonstrating improved predictive capability compared to conventional steady-state approaches. The analysis also includes an evaluation of the cavitation volume fraction and a depiction of pressure conditions on the impeller as functions of flow rate and inlet pressure. In conclusion, this study highlights the potential of advanced hybrid turbulence models (such as SAS or DES) as a promising direction for future research, which could further improve the prediction of complex cavitation phenomena in centrifugal pumps. Full article

Cadmium (Cd) is a toxic metal that affects living organisms even at low concentrations, causing physiological alterations and biomass reduction in plants. Arbuscular mycorrhizal fungi (AMF) represent a biological strategy that increases tolerance to heavy metals, although their specific mechanisms in sugarcane remain poorly understood. To address this knowledge gap, an open-field experiment was conducted to evaluate the effects of AMF on Cd accumulation, oxidative stress, photosynthetic pigments, enzymatic antioxidant system, and non-enzymatic antioxidant compounds in sugarcane variety CC 01-1940, using a randomized block design. Results showed that AMF established symbiosis with plants, retaining Cd in the roots and reducing its translocation to leaves. Additionally, they decreased Cd-induced oxidative stress by reducing lipid peroxidation (MDA) and proline content. Although an initial decrease in photosynthetic capacity was observed, AMF helped maintain stable levels of photosynthetic pigments, preserving photosynthetic efficiency. They also activated antioxidant enzymes and increased antioxidant compounds such as reduced glutathione (GSH), non-protein thiols (NP-SH), ascorbic acid (AA), and phytochelatins (PC). These findings demonstrate that symbiosis with AMF protects sugarcane plants from cellular oxidative damage and reduces Cd concentrations in leaves. Therefore, the use of AMF represents an effective strategy to improve the antioxidant defense and resistance of sugarcane plants to cadmium stress. Full article

This paper investigates the influence of airfoil parameters on the cavitation performance of water jet propulsion pumps through numerical simulation methods. The effects of a varying inlet pressure and different airfoil structures on the critical net positive suction head (NPSH), head, and efficiency were systematically studied. Subsequently, the impact pattern of the airfoil structure on the cavitation performance was analyzed. The results demonstrate that the NACA0009-16_0004-16 airfoil exhibited the lowest required NPSH and superior cavitation resistance relative to the other tested airfoils. Nevertheless, the NACA0009-13_0004-13 airfoil demonstrated an optimal comprehensive performance, balancing the efficiency, head, and cavitation resistance. By extracting a water velocity isosurface of 23.6 m/s, we further investigated the flow characteristics of the suction surfaces of different airfoils at different cavitation conditions and found that the cavitation mainly includes TIP cavitation and sheet cavitation. With an increasing cavitation intensity, the sheet cavitation region progressively develops axially from the blade tip towards the blade outlet, extends radially from the shroud to the hub, and eventually nearly extends over the entire blade surface. The area of the TIP cavitation also expands, spreading downward in the same direction as the impeller rotation. The velocity vector exhibits a significantly higher density near the shroud and blade tips, suggesting potential flow separation and complex vortex structures in these regions. Near the blade leading edge, the water velocity isosurface area contracts, whereas near the trailing edge, it expands. These alterations indicate that the cavitation development modifies the flow field velocity distribution and adversely affects the impeller performance. This study establishes a theoretical foundation and offers practical guidelines for the multi-objective collaborative design of water jet propulsion pumps. Full article

Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial tumors. Evidence suggests that these types of tumors may have high recurrence rates. In this context, the purinergic system, oxidative stress, and inflammation are important signaling pathways involved in the cancer’s pathophysiology. This study aimed to evaluate the sociodemographic and diagnostic profiles, as well as assess the purinergic signaling, immunological, and redox profiles, of patients after PitNET resection. We collected sociodemographic data and the patients’ diagnostic profiles. We also collected blood samples to analyze glycemia, triglycerides, albumin, and ATP levels. The ectonucleotidase activity was determined in peripheral blood mononuclear cells (PBMCs). In addition, we evaluated their redox and immunological profiles. There was a prevalence of gonadotropic macroadenoma derived from PIT-1 cells. We found that patients included in the PitNET group had increased glycemia, serum ATP levels, and ATP hydrolysis in PBMCs. Analyzing their immunological profiles, we found that patients had increased levels of IL-6, IL-10, and TNF, while the IL-27 level was decreased. Regarding their redox profiles, PitNET patients had increased levels of ROS and protein carbonylation. Unexpectedly, patients also showed increased levels of non-protein thiols (NPSHs), total thiols (PSHs), and ascorbic acid. Thus, the dysregulation of purinergic signaling sustained chronic inflammation and oxidative imbalance in PitNET patients for a long time after surgical resection. These data suggest that patients with PitNETs require long-term accompanying to prevent cancer recurrence prognosis. The biomarkers highlighted in this study may be good tools to help the medical approaches. Full article

The Northwestern Pacific Subtropical High (NPSH), usually enhanced by the basin-scale warming of the Indian Ocean (IOBW), plays a major role in controlling the summertime East Asian climate. To assess factors contributing to the decadal modulation of the NPSH and IOBW relationship in recent years, we conducted sensitivity experiments using an atmospheric general circulation model. We particularly focused on decadal-scale differences between the periods of 1982–2001 and 2002–2021, with the contribution of the climatological sea surface temperature (SST) as the background, in combination with the tropical Pacific SST anomaly in relation to the rapid or slow decay of the El Niño Southern Oscillation (ENSO). The results indicate that the IOBW-related SST anomalies in the Indian and tropical Pacific Oceans—which, overall, represent the well-known characteristics of the so-called Indo-western Pacific Ocean Capacitor effects—cooperatively enhanced the NPSH in the earlier period (1982–2001). On the other hand, the suppressed and westward-shifted SST anomalies in the tropical Pacific Ocean and the resultant changes in the diabatic heating of cumulus convection suppressed the NPSH enhancement in recent years (2002–2021). These results indicate that the modulation in the NPSH responses linked to the IOBW is primarily due to the so-called ENSO diversity rather than climatology. Full article

The objective was to determine whether dairy cows may activate traditional and alternative inflammatory pathways by consuming a combination of a phytogenic diet (essential oil and pepper resin). Twenty pregnant Jersey cows in the final (third) lactation phase (260 days in milk) were divided into two groups: control, with no additive consumption, and test, with the addition of the phytogenic to the concentrate portion of the diet (150 mg/day/kg dry matter). Blood samples were collected on experimental days 1, 7, 14, 21, 28, 35, and 42 by coccygeal vein puncture to assess the complete blood count, serum biochemistry of levels of total protein, albumin, and globulin, as well as carbohydrate metabolism (glucose), lipid metabolism (cholesterol and triglycerides), protein metabolism (urea), activities of hepatic enzymes (gamma-glutamyl transferase (GGT) and aspartate aminotransferase (AST)), cytokine levels (interleukins IL-1β, IL-6, and IL-10), antioxidant response [thiobarbituric acid reactive substances (TBARS), reactive oxygen species (ROS), total thiol (PSH), and non-protein thiol (NPSH), and glutathione S(GST)], cholinergic system [total cholinesterase (ChE) and acetylcholinesterase (AChE)], purinergic signaling [NTPDase, 5′ectonucleotidase and adenosine deaminase (ADA)], and energetic metabolism enzymes [creatine kinase (CK), pyruvate kinase (PK), and adenylate kinase (AK)]. Productive performance was assessed through feed intake and milk production. The results revealed that the use of phytogenic compounds significantly influenced the cholinergic system and purinergic signaling associated with immunology. The reduction in cholinesterase (ChE) activity and the increase in acetylcholinesterase (AChE) activity in lymphocytes suggest the modulation of the cholinergic system, enhancing the immune response. Furthermore, the elevated activity of adenosine deaminase (ADA) in lymphocytes and platelets, together with increased ATP and ADP hydrolysis in platelets, indicates the beneficial regulation of purinergic signaling, potentially contributing to inflammatory modulation. These effects were accompanied by a lower production of pro-inflammatory cytokines (IL-1β and IL-6) and a higher production of IL-10, reinforcing an anti-inflammatory profile. The reduced leukocyte and lymphocyte counts may reflect a lower inflammatory demand, while the increased levels of NPSH and GST antioxidants suggest cellular protection. Despite these physiological changes, productive performance and milk quality remained unaffected. In summary and practical terms, including this additive in the cows’ diet benefits the cow’s health in the final third of gestation when the animal already has a reduced immune response due to advanced gestation. Full article

Background: The role of sulfur-containing drugs, disulfiram (DSF) and N-acetylcysteine (NAC), in alleviating neuroinflammation is poorly understood. The objective of this study was to examine the effect of DSF and NAC on memory and on the metabolism of L-cysteine and inflammation-related parameters in the cerebral cortex of rats in a model of neuroinflammation induced by the administration of lipopolysaccharide (LPS). Methods: All the treatments were administered intraperitoneally for 10 days (LPS at a dose of 0.5 mg/kg b.w., DSF at a dose of 100 mg/kg b.w, and NAC at a dose of 100 mg/kg b.w.). Behavior was evaluated by the novel object recognition (NOR) test and object location (OL) test, and the level of brain-derived neurotrophic factor (BDNF) was assayed to evaluate neuronal functioning. Cerebral cortex homogenates were tested for hydrogen sulfide (H₂S), sulfane sulfur, sulfates, non-protein sulfhydryl groups (NPSH), nitric oxide (NO), and reactive oxygen species (ROS) by biochemical analysis. Results: Neither DSF nor NAC alleviated LPS-induced memory disorders estimated by the NOR test and OL test. The studied compounds also did not affect significantly the levels of BDNF, ROS, NO, H₂S, and sulfane sulfur in the cerebral cortex. However, we observed an increase in sulfate concentration in brain tissues after LPS treatment, while DSF and NAC caused an additional increase in sulfate concentration. On the other hand, our study showed that the administration of DSF or NAC together with LPS significantly enhanced the cortical level of NPSH, of which glutathione is the main component. Conclusions: Our study did not confirm the suggested potential of DSF and NAC to correct memory disorders; however, it corroborated the notion that they reduced oxidative stress induced by LPS by increasing the NPSH level. Additionally, our study showed an increase in sulfate concentration in the brain tissues after LPS treatment, which means the upregulation of sulfite and sulfate production in inflammatory conditions. Full article

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in therapy due to their anti-inflammatory and analgesic properties. However, their clinical use is often associated with gastrointestinal complications. Thus, this study aimed to investigate the protective effect of a sulfated iota-carrageenan isolated from the marine alga Solieria filiformis (IC-Sf) against naproxen-induced gastrointestinal injury. Methods: Parameters of gastrointestinal injury, secretory and motor functions, and toxicity were evaluated. Results: The results demonstrated that IC-Sf significantly reduced naproxen-induced gastrointestinal macroscopic injury, with a maximum effect observed at 30 mg/kg. IC-Sf also preserved gastrointestinal antioxidant defense and prevented lipid peroxidation, with a reduction in the non-protein sulfhydryl group (NP-SH) and malondialdehyde (MDA) concentrations induced by naproxen. Additionally, IC-Sf mitigated naproxen-induced gastrointestinal inflammation, as evidenced by reduced myeloperoxidase (MPO) activity, tumor necrosis factor-alpha (TNF-α), and interleukin-1 beta (IL-1β). IC-Sf did not alter gastric secretion or gastrointestinal motility. In addition, the animals treated with IC-Sf did not present toxic effects. Conclusions: In conclusion, IC-Sf protected the gastrointestinal tract against the harmful effects of naproxen by inhibiting the inflammatory response and lipid peroxidation, suggesting its potential as a new therapeutic agent or food additive. Full article

Cavitation phenomena in pumps are major determinants of the lifespan of both the impeller and the pump itself, causing significant vibration and noise, which are critical concerns for pump designers. This study focuses on the influence of various geometric factors of the impeller, including the shape of the blade leading edge, blade inlet angle, number and thickness of blades, surface roughness, wrap angle, impeller outlet width, inlet hub diameter, and tip clearance. The pump analyzed in this study, which exhibited issues of vibration and noise in actual industrial settings, was evaluated by varying only the shroud diameter based on Gulich’s theory, while keeping other parameters constant, to assess the effects on cavitation phenomena across five different impellers. Single-phase analysis was initially conducted to evaluate the performance of each pump model, with the reliability of the numerical analysis methods validated by comparison with experimental data. Furthermore, to analyze cavitation phenomena, a multiphase flow analysis was performed using the Rayleigh–Plesset model within a computational fluid dynamics framework. Quantitative analysis of cavitation occurrence, NPSH3% head-drop performance, and bubble volume was conducted. The results confirmed that the M1 model, featuring a shroud diameter of 560 mm, exhibited superior cavitation resistance. Variations in cavitation occurrence observed under three different flow conditions demonstrated a nonlinear trend, but overall, improvements were noted within a specific diameter range. This study offers valuable insights and data for pump design applicable in real-world industrial settings. Full article

Some high-specific-speed centrifugal pumps exhibit instability in terms of hydraulic performance and cavitation characteristics, and there’s a lack of reliable numerical models to guide the optimization of cavitation instability. This paper, by conducting a study on mesh independence, analyzes the cavitation curves and cavitation counters for various mesh combinations in the numerical model, The findings indicate that the boundary layer grid not only influences the location of peak points but also the size of the peak. To achieve a stable NPSH peak position, the y+ at the blade leading edge of high-specific-speed centrifugal pumps needs to be controlled between 20–80. The turbulence model, evaporation coefficient, and condensation coefficient were simulated using the orthogonal experimental design method, analyzing the impact of these parameters on the NPSH peak. A visual high-speed photography test rig was established, and rotating cavitation and sheet cavitation is found at part-load. By comparing the cavitation and pressure counters with high-speed photography images, a numerical model was obtained that closely mirrors the experimental cavitation characteristics. Full article

We assessed the effect of non-protein thiols (NPSH), reduced glutathione (GSH) and n-acetylcysteine (NAC), on resin shear bond strength (SBS) to hydrogen peroxide (H₂O₂)-treated dentin, and their effects on the characteristics of dentin in comparison to ascorbic acid (AA) and sodium thiosulfate (STS). H₂O₂-treated dentin was conditioned with 5% AA, GSH, NAC, or STS applied for 1 or 5 min. The positive control group received H₂O₂ without antioxidant application, and the first negative control group received distilled water (DW). The specimens received resin bonding immediately after treatment except for the second negative control group (delayed bonding). Microhardness, roughness, and topography were studied. The SBS values of all antioxidants were statistically greater than the positive control group (p < 0.05); however, NAC and AA applied for 1 min demonstrated the highest values, which were comparable to delayed bonding. All treatments removed the smear layer except DW, H₂O₂, and STS. The negative effect of H₂O₂ on resin–dentin bonding was mitigated by the application of the antioxidants; however, their efficiencies were dependent on the antioxidant type and time of application. NAC was more effective in optimizing resin bonding to bleached dentin compared to GSH at 1 min application and STS at both application times but was comparable to AA. Negligible negative effects on the substrate’s roughness and microhardness were detected. The antioxidant properties of the agent and its capacity to remove the smear layer are the processes underpinning the ability of a certain antioxidant to reverse the effect of H₂O₂ on bonding. Full article

Using the RNG k-ε turbulence model and a full cavitation model, this study numerically simulated cavitating flow-induced pressure fluctuations in a gerotor pump and analyzed the relationship between cavitating flow and pressure fluctuations. The results demonstrate that, as the inlet pressure decreases, the cavitation phenomenon in the gerotor pump intensifies, and the cavitation range in the rotor increases. Some of the vapor even spreads into the oil inlet groove, leading to high vapor content in the chamber that is in contact with the oil inlet groove. The pressure fluctuation characteristics of the flow field in the pump exhibit evident periodic changes. Under different cavitation conditions, the pressure fluctuation amplitude at the monitoring point decreases with increasing inlet pressure, whereas the main frequency of pressure fluctuation remains unaffected by cavitation conditions. The pressure fluctuation amplitude is the strongest at point O₁ of demarcation between the low-pressure and high-pressure zones in the chamber, and the volume between the oil inlet groove and the oil outlet groove serves as the main vibration source in the rotor pump. To ensure the stable and efficient operation of the gerotor pump, it is recommended to operate it at a larger NPSH. Full article

The effective and reliable performance of any pump can be significantly impacted by the piping system design. One of the essential points is the pump suction pipe. Poor design and dimension of the suction piping can lead to cavitation in the pump which affects its head and efficiency. The primary objective is to reduce the hydraulic losses of the suction piping in order to maintain a Net Positive Suction Head required by the pump. Suction piping is recommended to be short and straight, and branch connections, valves and elbows should be avoided, which is not always possible. In addition, cavitation can occur in the actual hydraulic elements installed on the pump suction. This work is focused on the investigation of cavitating hydraulic element in the suction pipe on the pump performance. A converging-diverging nozzle with a circular cross-section was used for this purpose. A straight pipe segment of constant diameter and the same length was used for comparison. Both elements were characterized by the loss coefficient and the cavitation number. Their influence on the pump head and the Net Positive Suction Head Available (NPSHA) was investigated. Full article

Pump-jet propellers are currently the mainstream propulsion method for underwater vehicles, and cavitation is an important factor limiting the high speed and miniaturization of pump-jet propellers. In order to explore the cavitation performance of high-speed pump-jet propellers, based on the modified SST turbulence model and the Zwart cavitation model, a three-dimensional numerical simulation of unsteady internal cavitation flow was carried out by comparing the impeller with specific speed n_s = 1920 using FLUENT 2020R2 software. At the same time, the occurrence and development process of cavitation under 0.95 Q, 1.0 Q, and 1.05 Q conditions were analyzed (Q is the mass flow), the changes in gas volume fraction in the impeller channel were captured, the distribution characteristics of cavitation under different NPSH values were explored, and the change law of cavitation with time was determined. The results show that, when NPSH dropped to 95 m, the impeller cavitation first occurred under the 1.05 Q operating condition, and the impeller cavitation volume fraction was 0.0379525. When NPSH dropped to 85 m, the impeller cavitation occurred under the 1.0 Q operating condition, and the impeller cavitation volume fraction was 0.0185164. When NPSH dropped to 80 m, the impeller cavitation occurred under the condition of 0.95 Q, and the volume fraction of the impeller cavitation was 0.013541. The high-speed pump-jet propeller had better anti-cavitation ability with a small flow rate. The cavitation distribution law under the three operating conditions was similar; cavitation was first generated on the impeller inlet edge and near the shroud, and the vacuoles with large volumes were mostly concentrated on the impeller inlet side. As the NPSH gradually decreased, the entire flow channel was gradually occupied by vacuoles. As the flow decreased, the corresponding NPSH also decreased. When NPSH dropped to 50 m, the volume fraction of the impeller under all three operating conditions reached around 0.4. As the cavitation only occurred on the suction surface, the volume fraction of the cavitation on the suction surface exceeded 0.8, at which time the impeller had already undergone severe cavitation. Within a complete cycle, bubbles first appeared at the inlet edge of the impeller (measured near the shroud) and gradually spread toward the middle and rear of the impeller, ultimately covering the suction surface of the impeller. Under the design condition, the experimental results of the model pump were consistent with the numerical simulation results, and the error was only 2.68%, thus verifying the reliability of the numerical simulation. The research results provide a reference for the in-depth study of the cavitation performance of high-speed pump-jet propellers and provide a good theoretical basis and practical significance in the engineering field for the high-speed and miniaturization process of high-speed pump-jet propellers. Full article

Over the years, Computational Fluid Dynamics (CFD) has been an integral part of most pump design processes. Unfortunately, as calculation schemes and flow investigations become more complicated, the cost of conducting numerical simulations also becomes more expensive in terms of computational time. To remedy this, cutting-edge technology, together with novel calculation techniques, are continuously introduced with the end target of producing more accurate results and faster computing time. In this paper, CFD simulations are run on a numerical model of a double-volute double-suction pump prepared using ANSYS Fluent Mosaic meshing technology. Poly-Hexcore, the first application of Mosaic technology, fills the bulk region with octree hexes, keeps a high-quality layered poly-prism mesh in the boundary layer, and conformally connects these two meshes with general polyhedral elements. This technology promises to provide a lower number of cells along with a significant increase in computing speed. In this paper, steady state results of the model with Mosaic Poly-Hexcore mesh with ~37% fewer cells produced comparable results with a similarly sized model prepared with multi-block structured hexagonal mesh. The predicted pump head, efficiency and shaft power under the design conditions were within 1% for both models, while calculation time was reduced by ~25%. Additional simulations using the Poly-Hexcore mesh showed that the model was able to closely predict the pump’s NPSH3 for $0.8Q_D$, $1.0Q_D$, and $1.2Q_D$ compared with the manufacturer’s data. Under cavitating flow conditions, the formation of vapor bubbles was observed on the suction side, starting at the leading edge of the blade and slowly forming as thin sheets towards the trailing edge as the suction pressure is reduced. Lastly, pressure fluctuations were observed from pressure coefficient data collected at several monitoring points in the volute and the impeller. It was seen that due to the interaction between the stationary casing and the rotating impeller, pulsations were equivalent to the blade passing frequency and its harmonics. Full article