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1 Citations

1,971 Views

15 Pages

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

Federica Matteucci,
Marta Ferrati,
Eleonora Spinozzi,
Alessia Piergentili,
Fabio Del Bello,
Gianfabio Giorgioni,
Leonardo Sorci,
Riccardo Petrelli and
Loredana Cappellacci

Pharmaceuticals2024, 17(6), 739;https://doi.org/10.3390/ph17060739

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6 June 2024

Nicotinamide adenine dinucleotide (NAD) cofactor metabolism plays a significant role in cancer development. Tumor cells have an increased demand for NAD and ATP to support rapid growth and proliferation. Limiting the amount of available NAD by target...

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Review

17 Citations

14,252 Views

34 Pages

Inhibitors of NAD⁺ Production in Cancer Treatment: State of the Art and Perspectives

Moustafa S. Ghanem,
Irene Caffa,
Fiammetta Monacelli and
Alessio Nencioni

Int. J. Mol. Sci.2024, 25(4), 2092;https://doi.org/10.3390/ijms25042092

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8 February 2024

The addiction of tumors to elevated nicotinamide adenine dinucleotide (NAD+) levels is a hallmark of cancer metabolism. Obstructing NAD+ biosynthesis in tumors is a new and promising antineoplastic strategy. Inhibitors developed against nicotinamide...

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Review

8 Citations

6,197 Views

14 Pages

The Role of NMNAT2/SARM1 in Neuropathy Development

Olga Tarasiuk,
Laura Molteni,
Alessio Malacrida and
Gabriella Nicolini

Biology2024, 13(1), 61;https://doi.org/10.3390/biology13010061

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22 January 2024

Chemotherapy-induced peripheral neuropathy (CIPN) commonly arises as a side effect of diverse cancer chemotherapy treatments. This condition presents symptoms such as numbness, tingling, and altered sensation in patients, often accompanied by neuropa...

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Article

30 Citations

6,708 Views

21 Pages

Targeting Nuclear NAD⁺ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells

Alexandra Kiss,
Arnold Péter Ráduly,
Zsolt Regdon,
Zsuzsanna Polgár,
Szabolcs Tarapcsák,
Isotta Sturniolo,
Tarek El‐Hamoly,
László Virág and
Csaba Hegedűs

Cancers2020, 12(5), 1180;https://doi.org/10.3390/cancers12051180

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7 May 2020

Osteosarcoma (OS) is the most common bone tumor in children and adolescents. Modern OS treatment, based on the combination of neoadjuvant chemotherapy (cisplatin + doxorubicin + methotrexate) with subsequent surgical removal of the primary tumor and...

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Article

3 Citations

2,782 Views

27 Pages

Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1

Kazuhiro Hasegawa,
Masanori Tamaki,
Yusuke Sakamaki and
Shu Wakino

Int. J. Mol. Sci.2024, 25(12), 6384;https://doi.org/10.3390/ijms25126384

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9 June 2024

Nicotinamide adenine dinucleotide (NAD) is involved in renal physiology and is synthesized by nicotinamide mononucleotide adenylyltransferase (NMNAT). NMNAT exists as three isoforms, namely, NMNAT1, NMNAT2, and NMNAT3, encoded by Nmnat1, Nmnat2, and...

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Review

1,471 Views

26 Pages

The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology

Yi-Ching Lee and
Su-Ju Lin

Int. J. Mol. Sci.2025, 26(18), 9098;https://doi.org/10.3390/ijms26189098

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18 September 2025

Nicotinamide adenine dinucleotide (NAD+) is an essential metabolite, and abnormal NAD+ metabolism has been linked to numerous human diseases. The nicotinamide mononucleotide adenylyl transferases (NMNATs) catalyze NAD+ production through both de novo...

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Article

5 Citations

4,555 Views

17 Pages

NMNAT1 Is a Survival Factor in Actinomycin D-Induced Osteosarcoma Cell Death

Alexandra Kiss,
Csaba Csikos,
Zsolt Regdon,
Zsuzsanna Polgár,
László Virág and
Csaba Hegedűs

Int. J. Mol. Sci.2021, 22(16), 8869;https://doi.org/10.3390/ijms22168869

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18 August 2021

Osteosarcoma is a frequent and extremely aggressive type of pediatric cancer. New therapeutic approaches are needed to improve the overall survival of osteosarcoma patients. Our previous results suggest that NMNAT1, a key enzyme in nuclear NAD+ synth...

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Perspective

10 Citations

6,991 Views

12 Pages

Why is NMNAT Protective against Neuronal Cell Death and Axon Degeneration, but Inhibitory of Axon Regeneration?

Bor Luen Tang

Cells2019, 8(3), 267;https://doi.org/10.3390/cells8030267

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21 March 2019

Nicotinamide mononucleotide adenylyltransferase (NMNAT), a key enzyme for NAD+ synthesis, is well known for its activity in neuronal survival and attenuation of Wallerian degeneration. Recent investigations in invertebrate models have, however, revea...

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Article

9 Citations

3,718 Views

15 Pages

NAD⁺ Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy

Xue Li,
Yankun Li,
Fengxia Li,
Qi Chen,
Zhonghua Zhao,
Xueguang Liu,
Nong Zhang and
Hui Li

Int. J. Mol. Sci.2022, 23(7), 3458;https://doi.org/10.3390/ijms23073458

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22 March 2022

The homeostasis of NAD+ anabolism is indispensable for maintaining the NAD+ pool. In mammals, the mainly synthetic pathway of NAD+ is the salvage synthesis, a reaction catalyzed by nicotinamide mononucleotide adenylyltransferase (NAMPT) and nicotinam...

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Article

2 Citations

1,562 Views

16 Pages

From Gene Networks to Therapeutics: A Causal Inference and Deep Learning Approach for Drug Discovery

Sudhir Ghandikota and
Anil G. Jegga

Pharmaceuticals2025, 18(9), 1304;https://doi.org/10.3390/ph18091304

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30 August 2025

Background/Objectives: Drug discovery is a lengthy and expensive process, taking an average of 10 years and more than USD 2 billion from target discovery to drug approval. It is even more challenging in complex diseases due to disease heterogeneity a...

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10 Results Found

Synthesis, Biological, and Computational Evaluations of Conformationally Restricted NAD-Mimics as Discriminant Inhibitors of Human NMN-Adenylyltransferase Isozymes

Inhibitors of NAD+ Production in Cancer Treatment: State of the Art and Perspectives

The Role of NMNAT2/SARM1 in Neuropathy Development

Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells

Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1

The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology

NMNAT1 Is a Survival Factor in Actinomycin D-Induced Osteosarcoma Cell Death

Why is NMNAT Protective against Neuronal Cell Death and Axon Degeneration, but Inhibitory of Axon Regeneration?

NAD+ Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy

From Gene Networks to Therapeutics: A Causal Inference and Deep Learning Approach for Drug Discovery

Inhibitors of NAD⁺ Production in Cancer Treatment: State of the Art and Perspectives

Targeting Nuclear NAD⁺ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells

NAD⁺ Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy