Search Results (217)

In this work, ternary Mo–Ni–X (X = Al, Co, Cr, Cu, Fe, W) thin films with nominal composition Mo₈₀Ni₁₀X₁₀ (at. %) were prepared by magnetron sputtering and evaluated as electrocatalysts for the hydrogen evolution reaction (HER) in alkaline media. The influence of alloy composition, substrate type, and deposition temperature on catalytic performance was systematically investigated. Electrochemical screening revealed a strong dependence of HER activity on both substrate conductivity and ternary alloying, with Al-, Cr-, and W-containing systems showing the best performance on glassy carbon substrates. This highlights the importance of interfacial charge-transfer efficiency in determining catalytic behavior. The Mo₈₀Ni₁₀Cr₁₀/GC system was selected for detailed analysis. Deposition temperatures ≥ 500 °C resulted in enhanced HER activity, reaching an overpotential of η₁₀ = −222 mV at j = −10 mA cm⁻². The improved performance is attributed to temperature-induced microstructural optimization and electrochemically driven surface reconstruction, leading to the formation of a Ni-enriched active interface. AFM analysis confirmed surface restructuring during operation, with roughness increasing from ~1 to ~3 nm, indicating the formation of additional electrochemically accessible active sites. XPS results suggest partial depletion of Mo during cycling, while Cr mainly contributes to structural stabilization of the evolving thin film. Overall, the results demonstrate that HER performance is governed by the coupled effects of alloy composition, substrate-dependent charge transport, and in situ surface reconstruction. This work highlights magnetron sputtering as a scalable approach for designing homogeneous noble-metal-free thin-film electrocatalysts with tunable activity. Full article

Cutaneous leishmaniasis (CL) is highly prevalent in northern Ethiopia but data on community knowledge, attitudes, and health-seeking behaviours remain limited. A cross-sectional survey was conducted between November and December 2022 in CL-endemic areas of Tigray using mixed sampling and a structured questionnaire administered to 512 households. Knowledge of CL transmission was poor: only 1% correctly identified sand flies as the vector, while 25% believed the disease was genetically acquired. Approximately 67% of participants perceived CL as stigmatizing, and 63.3% reported a preference for traditional or local treatments over biomedical care. Knowledge levels were higher among rural residents and in households with prior CL experience. Gender and education were significantly associated with treatment-seeking and prevention practices, and participants from households with previous CL episodes reported better practices overall. Despite this, most participants demonstrated limited knowledge, unfavourable attitudes and suboptimal treatment-seeking and prevention behaviours. These findings highlight a disconnect between high disease burden, perceived seriousness and stigma, and limited understanding of transmission and prevention. Targeted, community-based health education interventions are needed to improve awareness of transmission, reduce stigma, and enhance access to effective treatment in CL-endemic settings. Full article

Urban planners need scalable ways to monitor pedestrian conditions across heterogeneous cities, but conventional Level-of-Service (LOS) methods are often locally calibrated and difficult to transfer. This study proposes a city-adaptive framework for pedestrian LOS mapping using spatio-temporal graph models and few-shot transfer learning. Pedestrian count data from Melbourne, Dublin, and Zurich were converted into six ordinal LOS classes using city-specific percentile thresholds computed from the training data, yielding a relative congestion measure rather than an absolute cross-city standard. We developed a spatio-temporal graph transformer with an ordinal prediction head and evaluated it under in-domain, zero-shot, few-shot, and domain-adaptive settings. The results show strong in-domain performance in Melbourne (accuracy 79.7%; Acc ± 1 99.1%) and effective adaptation to the city-adaptive ordinal classification task. Few-shot fine-tuning with only 5% labeled target city data recovered 95–99% of in-domain performance, suggesting that small amounts of local supervision can substantially reduce calibration requirements in data-scarce environments. KernelSHAP analysis indicates that short-term temporal lag features dominate predictions across cities, whereas spatial and contextual features vary more strongly with local urban structure. The findings suggest that few-shot transfer learning can support pedestrian LOS estimation in cities with limited labeled data; however, the proposed LOS formulation should be interpreted as a city-specific relative indicator rather than an absolute measure of pedestrian comfort, crowding, or service quality. While the framework was evaluated across three cities, additional validation in diverse urban contexts and against perceptual measures of pedestrian experience remains necessary. Overall, the study contributes a city-adaptive framework for transferable relative LOS prediction rather than a universal cross-city LOS standard. Full article

Diffusers in diffuser-augmented wind turbines (DAWTs) require high-camber airfoils operating at low Reynolds numbers (Re), and their laminar separation bubbles (LSB) significantly complicate aerodynamic predictions. No prior study has experimentally validated XFOIL, k-ω SST, and γ-Re_θ models against simultaneous lift, drag, and chord-wise pressure coefficient (Cp) measurements for the customized high-camber airfoil at Re = 68,000 (68k), 118,000 (118k), and 159,000 (159k). Lift, drag, and Cp distributions were measured experimentally. The γ-Re_θ model demonstrated superior performance, achieving a lift maximum absolute percent error of 1.6–3.4%, near-zero bias, and a coefficient of determination >0.99. It accurately captured the LSB pressure plateau at mid-chord, with mean gross-averaged Cp percent errors of 8.1% and 2.1% for upper and lower surfaces, respectively. The k-ω SST model overpredicted lift by up to +9.8% at Re = 68k and underpredicted drag by up to 66%. XFOIL is unreliable specifically for separated transitional flows at Re < 118k, but improves at Re = 159k. The experimental dataset and validated transition-sensitive RANS approach provide a foundation for low-Re airfoil and DAWT diffuser design. Future work should extend measurements below Re = 50k and above 200k, including post-stall conditions, and system-level design of DAWT. Full article

Cystic echinococcosis (CE) caused by the parasite Echinococcus granulosus is a zoonotic disease of global concern. Because most African countries have not yet conducted systematic studies on CE, it is difficult to determine its exact status. However, as with any parasitic zoonotic disease, the first step in developing a comprehensive management and control strategy is to identify the host range, transmission risk factors, and national and regional epidemiological data. This review evaluated and summarized articles on CE retrieved from the PubMed and Africa Journal Online (AJOL) databases. Inclusion criteria were studies (including case reports) focused on the prevalence of CE in animals and humans between 1970 and 2025. This review revealed that although numerous early studies on CE exist, only a few were conducted in Africa from 1970 to 2025. Furthermore, data regarding population genetic composition and the role of wildlife in CE transmission remain scarce. This review systematically evaluated the prevalence and transmission of CE in Africa and identified priority areas for surveillance and control. Full article

This study presents an experimental performance evaluation of an oil-based indirect solar fryer system designed for injera baking. The system consists of a receiver vessel, a closed-loop delivery and return pipe network, and a 60 cm diameter aluminum baking plate with spiral grooves on its bottom surface. Heat transfer oil circulates within the closed loop to transfer thermal energy from the receiver to the baking plate. The system was experimentally investigated under controlled electrical heating conditions using input power levels of 1.0, 1.3, 1.6, 1.75, 2.0, and 2.4 kW, representing equivalent solar thermal input scenarios with varying intensity. The results confirmed the technical feasibility of the system for injera baking across all tested conditions, with performance strongly dependent on input power. At higher input levels (≥2.0 kW), faster heating and shorter baking cycles of approximately 2.5–3 min were achieved; however, increased oil temperatures and thermal instability were observed due to limited heat redistribution within the fixed low-flow circulation system. At lower input levels (≤1.3 kW), the system remained thermally stable but exhibited long initial heating times (up to approximately 85 min) and reduced operational efficiency, limiting its practical applicability. The most balanced performance was observed at intermediate input power levels of 1.6–1.75 kW, where the system achieved approximately 45–60 min initial heating time, stable temperature behavior during operation, and consistent baking cycles of about 3 min with 1 min reheating time. This range provided an optimal compromise between thermal efficiency, operational stability, and energy utilization under the present configuration. Overall, the study demonstrates that the indirect solar fryer system is a promising alternative for energy-efficient injera baking; however, performance is strongly influenced by thermal input and circulation conditions, highlighting the need for further optimization and validation under real solar operating environments. Full article

Introduction: Despite improved health service accessibility, neonatal mortality in Ethiopia remains high at 33 per 1000 live births. Thus, improving health facilities’ readiness across infrastructure, basic amenities, equipment, medications, laboratory services, Kangaroo Mother Care, infection prevention and control, staffing, and guidelines availability is critical for improving the quality of neonatal care and survival. Objective: The aim of this study was to evaluate the readiness of Ethiopian hospitals to provide services to small and sick newborns. Methods: This was a cross-sectional study including 208 hospitals across four regions in Ethiopia in 2021–2024, prior to the implementation of the Saving Little Lives program. Data was collected using an adapted World Health Organization’s Service Availability and Readiness Assessment tool and are presented using composite scores. Results: The mean composite readiness score for the 208 hospitals for providing services to small and sick newborns in labour and delivery wards was 59%, with domain-specific scores of 47% for basic amenities, 56% for essential neonatal care, and 74% for newborn resuscitation. Significant variation was seen across hospital levels, and basic amenities were available in 68%, 49%, and 43%, essential neonatal care in 68%, 81%, and 71%, and newborn resuscitation in 68%, 66%, and 50% of referral, general, and primary hospitals, respectively. The mean composite readiness score to provide newborn care in the neonatal care units was 57%. Scores varied by hospital levels, with scores of 73%, 64%, and 50% for referral, general, and primary hospitals, respectively. Domain-specific scores were 63% for basic amenities, 65% for equipment, 67% for medications, 63% for laboratory services, 25% for Kangaroo Mother Care, 68% for infection prevention and control, 55% for staffing, and 51% for guidelines availability. Functional bCPAP machines were available in 14% of labour and delivery wards and in 35% of neonatal care units. Conclusions: There was a substantial gap in readiness to provide care for small and sick newborns, and significant variations across hospital levels. Immediate actions must be taken to address the observed gaps to reach the sustainable development goal of reducing neonatal mortality to at least 12 per 1000 live births by 2030. Full article

Rumenitis is an inflammatory condition of the rumen, typically seen in adult cattle managed on high-energy diets. In calves, it is uncommon and often linked to ruminal drinking due to esophageal groove dysfunction. Early diagnosis is challenging due to nonspecific clinical signs. A one-month-old male Limousin calf was presented with persistent non-fetid fluid regurgitation, rhythmic mastication, inappetence, and progressive neurological signs. Clinical examination revealed signs of dehydration and neurological dysfunction. Laboratory evaluation demonstrated metabolic acidosis (pH 7.16), hyperkalemia, and elevated serum urea. Endoscopy identified diffuse mucosal hyperemia, erosions, and fluid accumulation in the rumen. Symptomatic and supportive therapy was initiated; however, the calf died spontaneously. Necropsy was therefore performed, and rumen samples were collected for histological and microbiological investigations. Histopathological analysis confirmed acute suppurative rumenitis. The microbiological culture of rumen and reticulum samples yielded mixed bacterial flora, including Escherichia coli and Proteus mirabilis. The fungal culture isolated Penicillium spp., Mucoraceae, Geotrichium spp., and Aspergillus fumigatus. This case details the value of integrating clinical examination, blood gas analysis, endoscopy, histopathology, and microbiology in diagnosing rumenitis in young calves. Although Limousin calves are not considered predisposed, management and feeding practices may play a critical role in disease onset. Rumenitis should be considered in calves presenting persistent regurgitation and neurological signs. Early, minimally invasive diagnostics such as endoscopy can improve diagnostic accuracy and inform timely clinical decision-making. Full article

Improving crop productivity largely depends on understanding soil fertility constraints and the effects of nutrient management on yield performance. Accurate determination of existing soil nutrient status and targeted application of limiting nutrients are essential for enhancing wheat (Triticum spp.) productivity. However, the specific effects of omitting one of the macronutrients such as nitrogen (N), phosphorus (P), or potassium (K) on wheat yield have not been investigated in the target area. This study employed the Quantitative Evaluation of the Fertility of Tropical Soils (QUEFTS) model to estimate the N, P, and K fertilizer requirements needed to achieve a predefined wheat yield target. The objectives were to: (i) evaluate yield responses to complete versus nutrient omission (N, P, or K) fertilization treatments, and (ii) analyze corresponding nutrient uptake and use efficiency dynamics. The experimental treatments included: (1) full NPK fertilization, (2) NP only (K omitted), (3) NK only (P omitted), (4) PK only (N omitted), and (5) an unfertilized control. Topsoil samples were analyzed and used as inputs for the QUEFTS model. Yield and agronomic data, as well as nutrient uptake and use efficiency, were measured. Model performance was validated using standard statistical metrics. Results showed that full NPK application significantly (p < 0.05) improved yield, yield components, and nutrient uptake compared to omission treatments and the control. The strong agreement between QUEFTS-predicted and observed yields highlights the model’s potential as a reliable, cost-effective decision-support tool for optimizing site-specific fertilizer recommendations. These findings demonstrate that balanced NPK fertilization markedly boosts wheat yield and nutrient uptake, while the QUEFTS model provides a powerful, reliable tool for tailoring fertilizer management to local soil conditions. Full article

Ongoing conflicts in sub-Saharan Africa negatively affect the population’s mental health and weaken health care systems. Collaboration among stakeholders is recommended to strengthen mental health services in post-conflict settings, despite limited evidence on context-specific strategies. This paper aimed to identify strategies for collaboration between traditional and biomedical services to improve mental health care. An adapted nominal group technique was employed during a one-day stakeholder workshop. Fourteen participants representing traditional and biomedical mental health services discussed and prioritised strategies based on importance and feasibility to reach consensus. Five collaborative care strategies were prioritised based on stakeholder consensus regarding importance and feasibility: (1) collaborative learning, (2) formalising coordination, (3) capacity building, (4) joint intervention programs, and (5) regulatory support. Key mechanisms for implementing these strategies were also identified, including piloting integrated interventions, appointing a dedicated focal person to coordinate, providing basic psychosocial counselling skills, reducing harmful practices, and strengthening supportive supervision. Mutual learning was identified as a crucial cross-cutting component of all approaches. The conclusion was that implementing these prioritised strategies could improve mental health care. Further research is needed to evaluate the effectiveness of these strategies in enhancing collaborative care and improving mental health outcomes for individuals. Full article

Background: Neonatal mortality remains a significant public health challenge in Ethiopia. Despite efforts to implement key evidence-based interventions, their coverage and utilization remain low. The Saving Little Lives (SLL) program aims to scale-up a Minimum Care Package (MCP) of synergistic, life-saving interventions for all liveborn neonates, with a focus on preterm and low birth weight (LBW) infants, across 290 hospitals in Ethiopia (206 primary, 69 general, and 15 referral hospitals), representing 82% of all hospitals in the country at the time of the study, and evaluate the impact on neonatal mortality. Methods: A non-randomized stepped-wedge trial will be conducted to evaluate the impact of implementing the SLL MCP interventions. Quantitative evaluation data will be collected from 36 primary hospitals, selected from 206 primary hospitals across four regions, receiving the interventions. An independent evaluation research assistant will be deployed in each of the hospitals to collect data using Open Data Kit (ODK) through interviewing mothers before discharge, on the 29th day of life if discharged, and reviewing medical records. A mixed-method, cross-sectional formative assessment will be conducted prior to implementation, employing quantitative facility assessment and qualitative interviews with mothers, healthcare providers, and facility managers. This will be followed by continuous program learning assessment once implementation begins. Descriptive data will be presented using numbers, percentages, tables, and graphs. Regression modeling and generalized estimating equations (GEEs) will be used to estimate the impact of the SLL MCP interventions. Qualitative data will be gathered through in-depth interviews, digitally recorded, transcribed, and thematically analyzed using ATLAS.ti Version 7.5 software to assess facility readiness, barriers, and enablers of implementing the SLL MCP interventions. Expected Outcome: We hypothesize that achieving 80% coverage of the SLL MCP interventions among eligible neonates will result in a 35% reduction in neonatal mortality at implementation facilities. Full article

Background: Urinary proteins may reflect physiological changes occurring during the periparturient period, but reference data for goats are still lacking. This study investigated urinary protein patterns around parturition to help fill this gap and generate baseline information. Methods: Ten pregnant Alpine goats were sampled by spontaneous voiding 22 ± 3 days before delivery (T0), 7 days postpartum (T7), and 30 days postpartum (T30). Physical and chemical urine analyses were performed, and urinary proteins were separated using one-dimensional sodium dodecyl sulfate–polyacrylamide gel electrophoresis. Statistical tests (Shapiro–Wilk, repeated-measures ANOVA, or Friedman) were applied to evaluate differences among time points. Results: Significant temporal changes were observed: urine pH decreased at T30, the urine protein-to-creatinine ratio increased at T7 and T30, and urinary creatinine concentration was highest at T0. Most samples showed common protein bands at approximately 80, 70, 62, 50, 37, 29, 25, 22, and below 13 kDa, with the 62, 50, and <13 kDa bands present in all samples. Bands between 18 and 64 kDa and above 60 kDa appeared only in some samples. Protein bands between 23 and 42 kDa were more frequent at T0, suggesting immune-related variations associated with pregnancy. Conclusions: This study provides the first description of urinary protein electrophoretic profiles in goats during the periparturient period and highlights measurable changes across time. These findings offer a starting point for developing future research and may contribute to establishing reference parameters for clinical and physiological monitoring in goats. Full article

Background: Large-scale production of poultry viral vaccines increasingly requires robust suspension cell platforms. However, most avian cell lines, including DF-1, are strictly anchorage-dependent, limiting scalability. Aquaporin-1 (AQP1) regulates cell–cell adhesion and membrane dynamics, making it a potential target for engineering suspension growth. This study aimed to generate a stable DF-1 suspension cell line via AQP1 disruption and evaluate its potential for enhanced infectious bursal disease virus (IBDV) production. Methodology: DF-1 cells were engineered using a CRISPR/Cas9 ribonucleoprotein system to create a truncated AQP1 gene. DF-1/AQP1⁻ cells were assessed for morphology, tumorigenicity in nude mice, and genetic stability across 20 passages. Suspension growth, cell density, and viability were measured. Cells were infected with IBDV strain BJQ902, and viral titers were compared with wild-type DF-1 and monolayer DF-1/AQP1⁻ cells. Results: DF-1/AQP1⁻ cells maintained normal morphology, were non-tumorigenic, and retained stable AQP1 mutations. They grew as true suspension cultures without adaptation, reaching 4.0 × 10⁶ cells/mL with >95% viability. Suspension DF-1/AQP1⁻ cells cells produced significantly higher viral titers (9.0 log TCID₅₀/mL; 8.63 log EID₅₀/mL) than both monolayer DF-1/AQP1⁻ and wild-type DF-1 cells. Virus production time was shortened in suspension cultures. Conclusions: Targeted AQP1 disruption converts DF-1 cells into a stable, non-tumorigenic suspension cell line with markedly enhanced IBDV production, providing a scalable platform for next-generation avian vaccine manufacturing. Full article

The contribution of members of the agri-food system to achieving the Sustainable Development Goals is a key element in the global transition to sustainable development. The use of sustainable management systems supports the development of an integrated approach with a spirit of continuous improvement. Such organization is based on risk-management tools that are applied to multiple stakeholders, e.g., those responsible for product quality, occupational health and safety, and environmental impact, thus enabling better global performance. In this review, the term “ethical food systems” is used in our discussion of the concrete methods that can be used to endorse fairness and concern across the food chain. This comprises safeguarding equitable access to nutritious foods, defending animal welfare, assisting ecologically accountable production, and addressing social and labor justice within supply chains. Ethical factors also include transparency, cultural respect, and intergenerational responsibility. Consequently, the objective of this review is to address how these ethical values can be implemented within a One Health framework, predominantly by assimilating plant-based diets, developing governance tools, and resolving nutritional insecurity. Within the One Health framework, decoding ethical principles into practice necessitates a set of concrete interventions: (i) raising awareness of animal rights; (ii) distributing nutritional and environmental knowledge; (iii) endorsing plant-based food research, commercialization, and consumption; (iv) development of social inclusion and positive recognition of vegan/vegetarian identity. At the same time, it should be noted that this perspective represents only one side of the coin, as many populations continue to consume meat and rely on animal proteins for their nutritional value; thus, the role and benefits of meat and other animal-derived foods must also be recognized and discussed. This operational definition provides a foundation for asking how ethical perspectives can be applied. A case study from Africa shows the implementation of a sustainable and healthy future through the One Health approach. Full article

This paper investigates wind speed, wind shear ($\alpha$), and turbulence intensity (TI) characteristics using measurements from meteorological mast data from three sites in the Geba Catchment, Tigray, Ethiopia: Dera, Hagere Selam, and Mayderhu. Wind speed analysis shows significant spatial and temporal variations, with Hagere Selam exhibiting the highest annual average wind speeds (8.0 m/s), while Dera showed the lowest (4.5 m/s). Diurnal and seasonal patterns indicated that wind speeds peak in the afternoon and vary with temperature, with Dera experiencing more pronounced vertical wind shear ($\alpha$ = 0.1–0.3) due to complex terrain interactions. In contrast, Hagere Selam and Mayderhu displayed lower shear ($\alpha$ = 0.0–0.1), suggesting smoother wind flow. Dera also showed pronounced diurnal $\alpha$ variations linked to nighttime cooling. TI was highest at Dera (TI ≈ 0.5), particularly at night, while Hagere Selam and Mayderhu maintained more stable conditions (TI < 0.25). Across all locations, analysis of wind speed variability revealed that Dera experiences greater turbulence compared to the International Electrotechnical Commission (IEC) standards but remains within acceptable limits for wind turbine operations. Wind direction analysis highlighted the prevailing winds at Dera, predominantly from the north, northeast, and southeast, which correspond to higher $\alpha$ and TI levels, emphasizing the role of local topography. Further, seasonal shifts were observed at Dera and Mayderhu, whereas Hagere Selam exhibited consistent northeasterly winds. The findings underscore the influence of topography and atmospheric stability on wind dynamics, providing critical insights for wind energy deployment in similar hilly terrains. Full article