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Ingramon-Depot Therapy in db/db Mice: The Impact on Local and Systemic Inflammation and Myocardial Remodeling

  • Anastasiia Yu. Filatova,
  • Natalya V. Radyukhina,
  • Andrei M. Karhov,
  • Ella V. Kurilina,
  • Natalya Yu. Ruleva,
  • Anastasia E. Yanina,
  • Ekaterina S. Ogurtsova,
  • Vladislav S. Kuzmin,
  • Maria V. Sidorova and
  • Tatiana I. Arefieva
Biomedicines2026, 14(10), 2341;https://doi.org/10.3390/biomedicines14102341

14 October 2026

Introduction. Chronic systemic inflammation is a major driver of myocardial fibrosis in patients with metabolic syndrome; accordingly, db/db mice with impaired leptin signaling are widely used to model myocardial injury associated with obesity and hy...

(This article belongs to the Special Issue Cardiometabolic Diseases: Molecular Biomarkers and Treatment Strategies)
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