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7 Results Found

  • Article
  • Open Access
140 Citations
18,750 Views
12 Pages

23 December 2010

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the n...

  • Article
  • Open Access
36 Citations
3,204 Views
12 Pages

14 March 2009

The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylid...

  • Article
  • Open Access
81 Citations
10,471 Views
15 Pages

Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

  • Milan Čačić,
  • Maja Molnar,
  • Bojan Šarkanj,
  • Elizabeta Has-Schön and
  • Valentina Rajković

29 September 2010

A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their...

  • Article
  • Open Access
22 Citations
17,630 Views
12 Pages

The Reaction of Ethyl 2-oxo-2H-chromene-3-carboxylate with Hydrazine Hydrate

  • Hatem A. Abdel-Aziz,
  • Tilal Elsaman,
  • Mohamed I. Attia and
  • Amer M. Alanazi

6 February 2013

Although salicylaldehyde azine (3) was reported in 1985 as the single product of the reaction of ethyl 2-oxo-2H-chromene-3-carboxylate (1) with hydrazine hydrate, we identified another main reaction product, besides 3, which was identified as malono...

  • Article
  • Open Access
119 Citations
19,192 Views
14 Pages

7 March 2006

(7-Hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide (2) was prepared from (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid ethyl ester (1) and 100% hydrazine hydrate. Compound 2, is the key intermediate for the synthesis of several series of new com...

  • Article
  • Open Access
14 Citations
2,840 Views
16 Pages

Radical Scavenging Activity and Pharmacokinetic Properties of Coumarin–Hydroxybenzohydrazide Hybrids

  • Marko R. Antonijević,
  • Edina H. Avdović,
  • Dušica M. Simijonović,
  • Žiko B. Milanović,
  • Ana D. Amić and
  • Zoran S. Marković

Free radicals often interact with vital proteins, violating their structure and inhibiting their activity. In previous studies, synthesis, characterisation, and the antioxidative properties of the five different coumarin derivatives have been investi...

  • Article
  • Open Access
13 Citations
2,557 Views
21 Pages

An Effective, Green Synthesis Procedure for Obtaining Coumarin–Hydroxybenzohydrazide Derivatives and Assessment of Their Antioxidant Activity and Redox Status

  • Edina H. Avdović,
  • Žiko Milanović,
  • Dušica Simijonović,
  • Marko Antonijević,
  • Milena Milutinović,
  • Danijela Nikodijević,
  • Nenad Filipović,
  • Zoran Marković and
  • Radiša Vojinović

1 December 2023

In this study, green synthesis of two derivatives of coumarin–hydroxybenzohydrazide, (E)-2,4-dioxo-3-(1-(2-(2,3,4-trihydroxybenzoyl)hydrazyl)ethylidene)-chroman-7-yl acetate (C–HB1), and (E)-2,4-dioxo-3-(1-(2-(3,4,5-trihydroxybenzoyl)hydr...