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Sci. Pharm.Scientia Pharmaceutica
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  • Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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14 March 2009

The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities

,
and
1
Faculty of pharmacy, October University for Modern Sciences & Arts, Elwahaat Road, October City, A. R. Egypt
2
Faulty of Science, Chemistry Department, Cairo University, A. R. Egypt
3
National Organization of Drug Control & Research (NODCAR), P.O. 29, Cairo, A. R. Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm.2009, 77(2), 355-366;https://doi.org/10.3797/scipharm.0901-20
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Abstract

The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2–10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs.

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