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5 Results Found

  • Article
  • Open Access
2 Citations
1,654 Views
18 Pages

5 August 2024

The yak (Bos grunniens) is a valuable livestock animal endemic to the Qinghai–Tibet Plateau in China with low reproductive rates. Cryptorchidism is one of the primary causes of infertility in male yaks. Compared with normal testes, the tight ju...

  • Article
  • Open Access
28 Citations
6,634 Views
18 Pages

Macrophage colony-stimulating factor (M-CSF or CSF-1) is known to have a broad range of actions on myeloid cells maturation, including the regulation of macrophage differentiation, proliferation and survival. Macrophages generated by M-CSF stimulus h...

  • Article
  • Open Access
6 Citations
2,630 Views
14 Pages

Targeting RAF Isoforms and Tumor Microenvironments in RAS or BRAF Mutant Colorectal Cancers with SJ-C1044 for Anti-Tumor Activity

  • Sungpyo Hong,
  • Myeongjin Jeon,
  • Jeonghee Kwon,
  • Hanbyeol Park,
  • Goeun Lee,
  • Kilwon Kim and
  • Soonkil Ahn

Colorectal cancer (CRC) is a significant global health issue characterized by a high prevalence of KRAS gene mutations. The RAS/MAPK pathway, involving KRAS, plays a crucial role in CRC progression. Although some RAS inhibitors have been approved, th...

  • Article
  • Open Access
1 Citations
3,331 Views
43 Pages

Restorative Effects of Synbiotics on Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic Enteropathy

  • Dipak Kumar Sahoo,
  • Tracey Stewart,
  • Emily M. Lindgreen,
  • Bhakti Patel,
  • Ashish Patel,
  • Jigneshkumar N. Trivedi,
  • Valerie Parker,
  • Adam J. Rudinsky,
  • Jenessa A. Winston and
  • Agnes Bourgois-Mochel
  • + 4 authors

Synbiotics can be used to reduce intestinal inflammation and mitigate dysbiosis in dogs with chronic inflammatory enteropathy (CIE). Prior research has not assessed the colonic mucosal ultrastructure of dogs with active CIE treated with synbiotics, n...

  • Article
  • Open Access
7 Citations
2,634 Views
15 Pages

Progression of Thoracic Aortic Dissection Is Aggravated by the hsa_circ_0007386/miR-1271-5P/IGF1R/AKT Axis via Induction of Arterial Smooth Muscle Cell Apoptosis

  • Xinsheng Xie,
  • Xiang Hong,
  • Shichai Hong,
  • Yulong Huang,
  • Gang Chen,
  • Yihui Chen,
  • Yue Lin,
  • Weifeng Lu,
  • Weiguo Fu and
  • Lixin Wang

Background: The molecular mechanisms associated with thoracic aortic dissection (TAD) remain poorly understood. A comprehensive high-throughput sequencing-based analysis of the circRNA–miRNA–mRNA competitive endogenous RNA (ceRNA) regulat...