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Article

2 Citations

2,956 Views

14 Pages

Expression of BARD1 β Isoform in Selected Pediatric Tumors

Anna Jasiak,
Natalia Krawczyńska,
Mariola Iliszko,
Katarzyna Czarnota,
Kamil Buczkowski,
Joanna Stefanowicz,
Elżbieta Adamkiewicz-Drożyńska,
Grzegorz Cichosz and
Ewa Iżycka-Świeszewska

Genes2021, 12(2), 168;https://doi.org/10.3390/genes12020168

26 January 2021

Currently, many new possible biomarkers and mechanisms are being searched and tested to analyse pathobiology of pediatric tumours for the development of new treatments. One such candidate molecular factor is BARD1 (BRCA1 Associated RING Domain 1)—a t...

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Brief Report

5 Citations

4,311 Views

10 Pages

Differential Expression of BARD1 Isoforms in Melanoma

Lorissa I. McDougall,
Ryan M. Powell,
Magdalena Ratajska,
Chi F. Lynch-Sutherland,
Sultana Mehbuba Hossain,
George A. R. Wiggins,
Agnieszka Harazin-Lechowska,
Bożena Cybulska-Stopa,
Jyoti Motwani and
Michael R. Eccles
+ 4 authors

Genes2021, 12(2), 320;https://doi.org/10.3390/genes12020320

23 February 2021

Melanoma comprises <5% of cutaneous malignancies, yet it causes a significant proportion of skin cancer-related deaths worldwide. While new therapies for melanoma have been developed, not all patients respond well. Thus, further research is requir...

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Article

8 Citations

4,047 Views

22 Pages

HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms

Aditi Jain,
Matthew McCoy,
Carolyn Coats,
Samantha Z. Brown,
Sankar Addya,
Carl Pelz,
Rosalie C. Sears,
Charles J. Yeo and
Jonathan R. Brody

Cancers2022, 14(7), 1848;https://doi.org/10.3390/cancers14071848

6 April 2022

Human Antigen R (HuR/ELAVL1) is known to regulate stability of mRNAs involved in pancreatic ductal adenocarcinoma (PDAC) cell survival. Although several HuR targets are established, it is likely that many remain currently unknown. Here, we identified...

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Review

18 Citations

6,320 Views

25 Pages

The Effects of Genetic and Epigenetic Alterations of BARD1 on the Development of Non-Breast and Non-Gynecological Cancers

Andrea K. Watters,
Emily S. Seltzer,
Danny MacKenzie,
Melody Young,
Jonathan Muratori,
Rama Hussein,
Andrej M. Sodoma,
Julie To,
Manrose Singh and
Dong Zhang

Genes2020, 11(7), 829;https://doi.org/10.3390/genes11070829

21 July 2020

Breast Cancer 1 (BRCA1) gene is a well-characterized tumor suppressor gene, mutations of which are primarily found in women with breast and ovarian cancers. BRCA1-associated RING domain 1 (BARD1) gene has also been identified as an important tumor su...

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Review

19 Citations

5,460 Views

12 Pages

BARD1 and Breast Cancer: The Possibility of Creating Screening Tests and New Preventive and Therapeutic Pathways for Predisposed Women

Marcin Śniadecki,
Michał Brzeziński,
Katarzyna Darecka,
Dagmara Klasa-Mazurkiewicz,
Patryk Poniewierza,
Marta Krzeszowiec,
Natalia Kmieć and
Dariusz Wydra

Genes2020, 11(11), 1251;https://doi.org/10.3390/genes11111251

24 October 2020

Current oncological developments are based on improved understanding of genetics, and especially the discovery of genes whose alterations affect cell functions with consequences for the whole body. Our work is focused on the one of these genes, BRCA1...

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Review

1,569 Views

23 Pages

BARD1: A Friend or Foe in Pancreatic Ductal Adenocarcinoma?

Lily Zekavat and
Aditi Jain

Int. J. Mol. Sci.2025, 26(18), 9041;https://doi.org/10.3390/ijms26189041

17 September 2025

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive solid malignancy with poor overall prognosis and limited response to standard treatments. Growing interest in the modulation of DNA repair mechanisms, including the homologous recombination (HR...

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