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8 Results Found

  • Article
  • Open Access
24 Citations
5,822 Views
11 Pages
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Distribution Assessments of Coumarins from Angelicae Pubescentis Radix in Rat Cerebrospinal Fluid and Brain by Liquid Chromatography Tandem Mass Spectrometry Analysis

  • Yan-Fang Yang,
  • Lei Zhang and
  • Xiu-Wei Yang
Molecules2018, 23(1), 225;https://doi.org/10.3390/molecules23010225

20 January 2018

Angelicae Pubescentis Radix (APR) is a widely-used traditional Chinese medicine. Pharmacological studies have begun to probe its biological activities on neurological disorders recently. To assess the brain penetration and distribution of APR, a vali...

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  • Open Access
26 Citations
5,072 Views
15 Pages
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Separation and Enrichment of Three Coumarins from Angelicae Pubescentis Radix by Macroporous Resin with Preparative HPLC and Evaluation of Their Anti-Inflammatory Activity

  • Yuqiao Yang,
  • Ruichao Zhu,
  • Jin Li,
  • Xuejing Yang,
  • Jun He,
  • Hui Wang and
  • Yanxu Chang
Molecules2019, 24(14), 2664;https://doi.org/10.3390/molecules24142664

23 July 2019

In order to enrich and separate three coumarins (columbianetin acetate, osthole and columbianadin) from Angelicae Pubescentis Radix (APR), an efficient method was established by combining macroporous resins (MARs) with preparative high-performance li...

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  • Open Access
43 Citations
7,877 Views
14 Pages
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Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability

  • Yan-Fang Yang,
  • Wei Xu,
  • Wei Song,
  • Min Ye and
  • Xiu-Wei Yang
Molecules2015, 20(7), 11719-11732;https://doi.org/10.3390/molecules200711719

25 June 2015

Angelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine, is reported to have central nervous system activities. The purpose of this study was to characterize the blood-brain barrier permeability of twelve coumarins from APR incl...

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  • Open Access
1,301 Views
18 Pages
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Angelicae Pubescentis Radix Remitted Intestine Damage in Mice Induced by Escherichia coli via Mediating Antioxidant Defense, Inflammatory Mediators, and Restoring Gut Microbiota

  • Kehong Deng,
  • Chang Xu,
  • Qing He,
  • Muhammad Safdar,
  • Mudassar Nazar,
  • Xiaocong Li and
  • Kun Li
Vet. Sci.2025, 12(4), 354;https://doi.org/10.3390/vetsci12040354

10 April 2025

This study aims to explore the therapeutic potential of Angelicae Pubescentis Radix (APR), a traditional Chinese medicine that is widely known for its anti-inflammatory, anti-oxidative, and anti-microbial properties, using a mouse model. In this stud...

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  • Open Access
39 Citations
6,747 Views
12 Pages
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Rapid Authentication of the Herbal Medicine Plant Species Aralia continentalis Kitag. and Angelica biserrata C.Q. Yuan and R.H. Shan Using ITS2 Sequences and Multiplex-SCAR Markers

  • Wook Jin Kim,
  • Byeong Cheol Moon,
  • Sungyu Yang,
  • Kyeong Suk Han,
  • Goya Choi and
  • A Yeong Lee
Molecules2016, 21(3), 270;https://doi.org/10.3390/molecules21030270

29 February 2016

Accurate identification of the plant species that are present in herbal medicines is important for quality control. Although the dried roots of Aralia continentalis (Araliae Continentalis Radix) and Angelica biserrata (Angelicae Pubescentis Radix) ar...

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  • Open Access
6 Citations
2,790 Views
14 Pages
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Graphene Assisted in the Analysis of Coumarins in Angelicae Pubescentis Radix by Dispersive Liquid–Liquid Microextraction Combined with 1H-qNMR

  • Yanmei Feng,
  • Qian Li,
  • Daiyu Qiu and
  • Guichen Li
Molecules2021, 26(9), 2416;https://doi.org/10.3390/molecules26092416

21 April 2021

The content of active components in traditional Chinese medicine is relatively small, and it is difficult to detect some trace components with modern analytical instruments, so good pretreatment and extraction are very important in the experiment. Gr...

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  • Open Access
19 Citations
3,030 Views
16 Pages
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Osthole Suppresses Knee Osteoarthritis Development by Enhancing Autophagy Activated via the AMPK/ULK1 Pathway

  • Teng Ma,
  • Xiangpeng Wang,
  • Wenjing Qu,
  • Lingsen Yang,
  • Cheng Jing,
  • Bingrui Zhu,
  • Yongkui Zhang and
  • Wenpeng Xie
Molecules2022, 27(23), 8624;https://doi.org/10.3390/molecules27238624

6 December 2022

Knee osteoarthritis (KOA) is an increasingly prevalent heterogeneous disease characterized by cartilage erosion and inflammation. As the main chemical constituent of Angelicae Pubescentis Radix (APR), an anti-inflammatory herbal medicine, the potenti...

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  • Open Access
5 Citations
2,471 Views
14 Pages
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Anti-Inflammatory Effect of Columbianadin against D-Galactose-Induced Liver Injury In Vivo via the JAK2/STAT3 and JAK2/p38/NF-κB Pathways

  • Zhe Ma,
  • Lin Peng,
  • Yaoyao Sheng,
  • Wenhui Chu and
  • Yongqian Fu
Pharmaceuticals2024, 17(3), 378;https://doi.org/10.3390/ph17030378

15 March 2024

Angelicae pubescentis radix (APR) has been traditionally used for thousands of years in China to treat rheumatoid arthritis (RA), an autoimmune disorder. As the main active coumarin of APR, columbianadin (CBN) exhibits a significant anti-inflammatory...

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