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22 pages, 2209 KB  
Systematic Review
Insurance Payor Status and Outcomes in Foot and Ankle Surgery
by Emily J. Luo, Dana G. Rowe, Kevin A. Wu, Aaron D. Therien, Mikhail Bethell, Kwabena Adu-Kwarteng, Sarah Lu, Samantha Kaplan, Samuel B. Adams and Albert Anastasio
Osteology 2026, 6(2), 7; https://doi.org/10.3390/osteology6020007 - 2 Apr 2026
Viewed by 363
Abstract
Background/Objectives: The increasing prevalence of foot and ankle procedures in the United States has coincided with rising costs of care, exposing socioeconomic disparities within this area of orthopedics. Insurance payor status is one such factor that can affect the quality and accessibility of [...] Read more.
Background/Objectives: The increasing prevalence of foot and ankle procedures in the United States has coincided with rising costs of care, exposing socioeconomic disparities within this area of orthopedics. Insurance payor status is one such factor that can affect the quality and accessibility of medical care and has been implicated in orthopaedic patient outcomes. While previous studies in other fields of orthopaedics have demonstrated an association between insurance status and access to treatment, length of hospital stay, post-operative outcomes and complication rates, no comprehensive review has yet explored this relationship in foot and ankle surgery. Thus, the goal of this study is to examine the association between insurance payor status and outcomes in foot and ankle procedures. Methods: A systematic review of five databases was conducted, focusing on the interplay between insurance coverage and foot/ankle procedures. Included studies reported on insurance payor status and patient outcomes following foot and ankle surgery. Extracted outcomes included time to be seen by a provider, complication and revision rates, post-operative Emergency Department (ED)/Urgent Care utilization, readmission rates, hospital length of stay, pain, functional scores, discharge destinations, return to work/activity, and follow-up. Meta-analyses were performed using the Revman 5.3 software. Studies that did not qualify for meta-analyses were described qualitatively. Results: Of 1401 studies identified, 24 texts met inclusion and exclusion criteria. Across the 24 studies, there were a total of 20,950 patients. Noninsured patients had a 59% higher risk of ED/urgent care utilization within 30 days of surgery compared to insured patients [Risk Ratio (RR) = 1.59, 95% Confidence Interval (CI) = 1.18 to 2.12, p < 0.05]. Privately insured patients were seen 3.65 days earlier than patients with government insurance [95% CI = 2.02 to 5.27, p < 0.0001]. Worker’s Compensation patients had statistically significant findings for poorer outcomes, higher pain scores, and lower functional scores. Similarly, Medicaid patients also fared worse on functional scores and had delayed access to appointments and treatments. Conclusions: Patients without private insurance have worse pain and functional outcomes, delayed access to care, and increased utilization of emergency resources following foot and ankle procedures. It is crucial for providers to be cognizant of these discrepancies when caring for patients. Further research is needed to better understand the nuances of these insurance-related disparities within foot and ankle subspecialties. Full article
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13 pages, 763 KB  
Review
Management of the Patella in Revision Total Knee Arthroplasty: A Narrative Review of Available Techniques
by Giorgio Carrozzi, Luca Saccone, Luca La Verde, Angelo Baldari, Antonio Caldaria, Gian Mauro De Angelis D’Ossat, Alessio Palumbo, Matteo Guzzini and Francesco Franceschi
Osteology 2026, 6(2), 6; https://doi.org/10.3390/osteology6020006 - 25 Mar 2026
Viewed by 502
Abstract
Background: In revision total knee arthroplasty (rTKA), clinical focus is mainly on the femoral and tibial components, while patellar complications are often underemphasized. However, patellar bone deficiency is a significant issue that can negatively affect surgical outcomes, especially in septic revisions. Objective: [...] Read more.
Background: In revision total knee arthroplasty (rTKA), clinical focus is mainly on the femoral and tibial components, while patellar complications are often underemphasized. However, patellar bone deficiency is a significant issue that can negatively affect surgical outcomes, especially in septic revisions. Objective: This review provides an overview of contemporary approaches to the evaluation and treatment of patellar bone loss in rTKA, emphasizing preoperative planning, classification frameworks, and treatment options. Methods: A narrative review of the literature was conducted. Studies published between 2000 and 2024 addressing preoperative assessment, surgical techniques, and outcomes in the management of patellar bone loss in rTKA were screened. Discussion: A recent consensus has addressed the evaluation, classification, and treatment of significant bone loss after total knee arthroplasty (TKA), providing specific recommendations for the management of patellar bone loss and extensor mechanism involvement in cases of severe bone deficiency. In this review, the principal surgical strategies described in the literature are summarized, including patellar component retention or revision, the use of biconvex inlay and trabecular metal implants, bone grafting, various augmentation techniques, resection arthroplasty, gull-wing osteotomy, and patellectomy. Conclusions: Despite various surgical strategies, no consensus exists on a universally superior approach. Ongoing research is essential to establishing standardized, evidence-based protocols for effective management of patellar bone loss in rTKA. Full article
(This article belongs to the Special Issue New Trends in Arthroplasty)
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14 pages, 5800 KB  
Article
Stepping Up: Accessory Bones of the Foot in the 21st Century Identified Skeletal Collection (Portugal)
by Larisa Sambú, Francisco Curate and Ana Maria Silva
Osteology 2026, 6(1), 5; https://doi.org/10.3390/osteology6010005 - 3 Mar 2026
Viewed by 791
Abstract
Background/Objectives: The anatomical variability of the human foot represents a subject of substantial interest, offering valuable insights in anthropological research as well as in clinical practice. The aim of this study is to document anatomical variants of the tarsal bones in a [...] Read more.
Background/Objectives: The anatomical variability of the human foot represents a subject of substantial interest, offering valuable insights in anthropological research as well as in clinical practice. The aim of this study is to document anatomical variants of the tarsal bones in a CISC//XXI skeletal sample (21st Century Identified Skeletal Collection), with a particular focus on the prevalence of accessory ossicles. Methods: The studied sample consisted of 163 individuals (83 females and 80 males). The prevalence of six accessory tarsal bones was recorded (os trigonum, calcaneum secundarium, the accessory navicular bone, os sustentaculum, os vesalianum and os intermetatarseum). Results: A total of 35 individuals (21.4%; 35/163) exhibited at least one accessory ossicle, with 13 females (15.7%; 13/83) and 22 males (27.5%; 22/80). The os trigonum and calcaneum secundarium were the most frequently observed accessory bones, respectively, in 9.3% (15/162) and 6.9% (11/159) of the individuals. No sex differences were observed. All accessory bones occurred more frequently unilaterally, and no co-occurrences of accessory bones were observed. Conclusions: These findings are crucial in both the biomedical and anthropological fields, where a detailed knowledge of foot anatomy and its variations is relevant. Full article
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14 pages, 1772 KB  
Article
Accuracy of Deep Learning-Driven MR Arthrography of the Shoulder: Compressed 3D in Comparison to Standard FSE Sequences
by Gianluca Tripodi, Flavio Spoto, Giuseppe Ocello, Leonardo Monterubbiano, Paolo Avanzi and Giovanni Foti
Osteology 2026, 6(1), 4; https://doi.org/10.3390/osteology6010004 - 27 Feb 2026
Viewed by 480
Abstract
Background/Objectives: Magnetic resonance arthrography is the reference standard for evaluating glenoid labral lesions. Deep learning (DL) reconstruction algorithms may accelerate 3D acquisitions while maintaining image quality. This study assesses the diagnostic accuracy of DL-based isotropic 3D MR imaging for detecting glenoid labral lesions. [...] Read more.
Background/Objectives: Magnetic resonance arthrography is the reference standard for evaluating glenoid labral lesions. Deep learning (DL) reconstruction algorithms may accelerate 3D acquisitions while maintaining image quality. This study assesses the diagnostic accuracy of DL-based isotropic 3D MR imaging for detecting glenoid labral lesions. Methods: This prospective study included 128 consecutive patients (79 men, 49 women; mean age 38.4 years) undergoing shoulder MR arthrography between June 2023 and April 2025. DL-based 3D sequences (acquisition time: 3:26) were compared with conventional multiplanar TSE and PD-FS sequences (acquisition time: 24–28 min). Two independent radiologists assessed glenoid labral lesions, bone marrow edema, and rotator cuff abnormalities using a four-point Likert scale. Sensitivity, specificity, and interobserver agreement were calculated. Results: DL-based 3D sequences demonstrated 94.7–95.1% sensitivity and 100% specificity for glenoid labral lesions, with excellent interobserver agreement (κ = 0.812). The area under the ROC curve was 0.894. Combined 3D protocols (T1 + PD-FS) showed superior accuracy (97.8%) compared to single sequences (90.5%, p = 0.012). For bone marrow edema, sensitivity was 82.9% with 100% specificity. Rotator cuff evaluation achieved 75% sensitivity with 100% specificity. Conclusions: DL-based isotropic 3D sequences provide high diagnostic accuracy for glenoid labral pathology while reducing scan time by 75%. Combined T1 and PD-FS protocols optimize performance. These findings support selective implementation of DL-accelerated 3D protocols in shoulder MR arthrography, particularly for labral assessment, while acknowledging that conventional protocols may remain preferable in specific clinical scenarios. Full article
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11 pages, 3230 KB  
Case Report
Bone Healing After Tooth Extraction in a Patient on Oral Bisphosphonates: A Case Report
by Antonello Falco, Lorenzo Vittorini Orgeas, Roberta Di Pietro, Loredana Masciotra, Sergio Rexhep Tari, Calogero Bugea and Antonio Scarano
Osteology 2026, 6(1), 3; https://doi.org/10.3390/osteology6010003 - 16 Feb 2026
Viewed by 798
Abstract
Background: The present case report study aims to describe, from both clinical and histological aspects, the bone healing pattern in a patient under oral bisphosphonates therapy. Case Presentation: an 82-year-old female patient has been under oral nitrogen bisphosphonates therapy for two [...] Read more.
Background: The present case report study aims to describe, from both clinical and histological aspects, the bone healing pattern in a patient under oral bisphosphonates therapy. Case Presentation: an 82-year-old female patient has been under oral nitrogen bisphosphonates therapy for two years. She underwent a tooth extraction. After four months, two bone biopsies were harvested, during standard implant drilling procedures. The first one corresponded to the healed alveolar socket of the previously extracted tooth (specimen A), while the second one corresponded to the bone ridge that was edentulous before starting the bisphosphonates therapy (specimen B). Morphometric and histologic analyses were performed. Results: In both, the bone resulted vital and no evidence of empty lacunae was detected. A reduction in the haversian canal diameter was observed in specimen B. The present case report highlights histological findings suggesting that patients undergoing oral bisphosphonates therapy may be eligible for surgical therapy. A pre-operative careful anamnesis and the observance of international guidelines for treating patients taking bisphosphonates are mandatory. Conclusions: These preliminary results will be used to plan a large clinical study in order to better understand the influence of bisphosphonates on the bone healing process. Full article
(This article belongs to the Special Issue Biomechanics of Bone and Dental Implants)
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18 pages, 4475 KB  
Review
A Comprehensive Review of Bone Remodeling After Trauma and Operative Treatment in Orthopedic Surgery
by Sarah E. Rabin, Ian P. Marshall, Benjamin A. Nelson, Justine N. Li, Madison M. Baldauf, Ashley B. Bozzay and Benjamin W. Hoyt
Osteology 2026, 6(1), 2; https://doi.org/10.3390/osteology6010002 - 13 Feb 2026
Viewed by 1459
Abstract
Bone remodeling is a dynamic process involving bone resorption and formation that is regulated on a cellular level and impacted by mechanical stress. A variety of Orthopedic surgery treatment strategies can affect bone remodeling, which can in turn may have long-term impacts on [...] Read more.
Bone remodeling is a dynamic process involving bone resorption and formation that is regulated on a cellular level and impacted by mechanical stress. A variety of Orthopedic surgery treatment strategies can affect bone remodeling, which can in turn may have long-term impacts on skeletal stress tolerance and function. This review provides a comprehensive overview of bone remodeling involved in Orthopedic surgery. Materials related to bone remodeling principles across Orthopedic surgery domains were selected and compiled using databases including PubMed, MEDLINE, AccessMedicine, and CINAHL; case studies were not included. Relevant literature was summarized for a general review of bone remodeling and as it relates to treatment principles in trauma, arthroplasty, and amputation with the aim of providing a relevant, comprehensive review. Overall, the purpose of this review is to provide an overview of bone remodeling principles that are implicated in various techniques within Orthopedic surgery. Full article
(This article belongs to the Special Issue Advances in Bone and Cartilage Diseases)
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14 pages, 296 KB  
Article
Young People’s Knowledge of Factors Associated with Bone Health in New Zealand: A Qualitative Study
by Hansa Patel, Maya Patel, Leah Clark, Hayley Denison, Paul Teesdale-Spittle and Elaine Dennison
Osteology 2026, 6(1), 1; https://doi.org/10.3390/osteology6010001 - 14 Jan 2026
Viewed by 967
Abstract
Background: Low peak bone mass (PBM) is a major contributor to later osteoporosis risk. This study sought to understand young people’s knowledge of factors associated with bone health. Methods: Young people in Aotearoa New Zealand were approached. Eight focus groups (26 [...] Read more.
Background: Low peak bone mass (PBM) is a major contributor to later osteoporosis risk. This study sought to understand young people’s knowledge of factors associated with bone health. Methods: Young people in Aotearoa New Zealand were approached. Eight focus groups (26 participants in total, aged 11 to 17 years) were conducted using a semi-structured approach with open-ended questions and prompts. Transcripts were thematically coded using an inductive content analysis approach. Results: Knowledge of factors associated with good bone health was limited. There was a general awareness of the positive and negative impacts of many lifestyle behaviours on health generally, but not specifically PBM. Dairy intake was commonly mentioned as being beneficial for bone health. Some participants reported potential benefits of sport, but most did not know that weight bearing activity specifically was beneficial. Conclusions: Knowledge of osteoporosis and lifestyle factors that impact PBM was limited. Educational interventions involving promotion of bone health knowledge and supporting weight bearing physical activity in adolescents may be an important contributor to public health strategies. Full article
14 pages, 474 KB  
Article
The Effect of Age and Symptom Duration on Patient-Reported Outcomes at 2- and 5-Year Follow-Up in Patients Undergoing Hip Arthroscopy for Femoroacetabular Impingement Syndrome
by Michael Moore, Samuel R. Montgomery, Larry Chen, Andrew Lehman, Sarah Levitt, Daniel J. Kaplan and Thomas Youm
Osteology 2025, 5(4), 37; https://doi.org/10.3390/osteology5040037 - 10 Dec 2025
Viewed by 1194
Abstract
Background/Objectives: To determine whether patients under 30 years of age who have experienced symptoms for a duration of less than 1 year before undergoing hip arthroscopy (HA) for femoracetabular impingement (FAI) have better patient-reported outcomes than patients aged 40 years or older who [...] Read more.
Background/Objectives: To determine whether patients under 30 years of age who have experienced symptoms for a duration of less than 1 year before undergoing hip arthroscopy (HA) for femoracetabular impingement (FAI) have better patient-reported outcomes than patients aged 40 years or older who have experienced symptoms for a duration of more than 1 year. Methods: This is a single-center, single-surgeon, retrospective analysis performed between August 2007 and May 2023 analyzing patients who underwent hip arthroscopy. Patients were divided into those who were 18 to 30 years old and patients that were 40 years and older. All patients who underwent primary hip arthroscopy for FAI and had completed mHHS or NAHS surveys prior to surgery with at least a 2-year follow-up were initially included in the study. Patients were excluded if they had no symptom duration information documented in their electronic medical record, a history of inflammatory arthritis, previous ipsilateral hip surgery, or future conversion to total hip arthroplasty (THA) before final follow-up. Results: A total of 236 hip arthroscopies were analyzed, including 147 patients ≥40 years and 89 patients 18–30 years, with symptom duration being significantly longer in the older cohort (28.4 vs. 17.5 months, p < 0.001). At 2 years, there was no difference in mHHS or NAHS between groups; however, younger patients with shorter symptom duration were more likely to achieve PASS for NAHS (87.5% vs. 58.7%, p = 0.036). At 5 years, the older cohort showed greater improvement in mHHS (33.1 vs. 22.9, p = 0.048), while patients 18–30 years continued to demonstrate higher absolute mHHS and NAHS at both 2 and 5 years. Regression analysis confirmed that increasing age was associated with lower PROs at follow-up. Conclusions: There was a significantly greater number of patients who achieved PASS for NAHS at 2-year follow-up for patients who were 18–30 years old with symptom duration ≤ 1 year compared to those aged 40+ years old with symptom duration ≥ 1 year. Additionally, patients ≥40 years old experienced a significantly longer symptom duration before surgery and had worse outcomes for mHHS and NAHS at 2- and 5-year follow-up compared to the 18–30 year cohort. Full article
(This article belongs to the Special Issue New Trends in Arthroplasty)
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21 pages, 635 KB  
Systematic Review
Outcomes of Primary Fusion vs. Reconstruction of Pediatric Cavus Foot in Charcot-Marie-Tooth Disease: A Systematic Review
by Waleed Kishta, Karim Gaber, Zhi Li, Bahaaldin Helal, Khubaib Wariach, Ahmad Ibrahim and Juliana Onesi
Osteology 2025, 5(4), 36; https://doi.org/10.3390/osteology5040036 - 9 Dec 2025
Viewed by 1250
Abstract
Background/Objectives: Charcot-Marie-Tooth (CMT) disease, the most common hereditary peripheral neuropathy, often causes cavovarus foot deformity in children. Surgical interventions to correct deformity or improve function can involve either primary fusion or reconstruction. However, the optimal surgical approach remains contested. This systematic review [...] Read more.
Background/Objectives: Charcot-Marie-Tooth (CMT) disease, the most common hereditary peripheral neuropathy, often causes cavovarus foot deformity in children. Surgical interventions to correct deformity or improve function can involve either primary fusion or reconstruction. However, the optimal surgical approach remains contested. This systematic review aims to present and evaluate existing data on both fusion and reconstruction surgical interventions in treating pediatric CMT cavus foot. Methods: A PRISMA-guided search of five electronic databases was conducted (from inception to 17 February 2025). Studies were eligible if they reported surgical outcomes for CMT pediatric patients (18 years) with cavovarus foot treated by primary fusion or reconstruction. Titles, abstracts and full texts were screened by four independent reviewers, and data were extracted on patient demographics, procedures, follow-up, functional scores, radiographic correction and complications. Results: Fourteen studies met inclusion criteria, encompassing 169 patients and 276 feet, with a mean age at surgery of ~13.5 years. Nine studies evaluated joint-sparing reconstruction, three assessed primary fusion, and two combined both reconstruction and fusion. Both interventions yielded improved outcomes post-operatively. Reconstruction generally produced high patient satisfaction and near-normal radiographic parameters but carried recurrence or reoperation rates of 10–40%. Fusion provided durable correction of rigid deformities but was associated with nonunion, adjacent joint arthritis and higher revision rates. Conclusions: Joint-sparing reconstruction is an effective first-line approach for flexible cavovarus deformities in pediatric CMT patients, while fusion should be reserved for severe, rigid or recurrent cases. A patient-specific staged approach is recommended, and higher-quality comparative studies are needed to refine surgical decision-making. Full article
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14 pages, 376 KB  
Article
Validation of Combined Indicator Using Joint Index Vector and Pain Score for Risk Weight Calculation of Incident Bone Fragility Fracture in Patients with Rheumatoid Arthritis
by Ichiro Yoshii, Naoya Sawada and Tatsumi Chijiwa
Osteology 2025, 5(4), 35; https://doi.org/10.3390/osteology5040035 - 20 Nov 2025
Viewed by 643
Abstract
Background: Risk factors, including Joint Index Vector (JIV), a new disease activity indicator based on three-axis coordinates, and a pain score using a visual analog scale (PS-VAS), were evaluated for incident bone fragility fractures (inc-BFF) in patients with rheumatoid arthritis (RA) in [...] Read more.
Background: Risk factors, including Joint Index Vector (JIV), a new disease activity indicator based on three-axis coordinates, and a pain score using a visual analog scale (PS-VAS), were evaluated for incident bone fragility fractures (inc-BFF) in patients with rheumatoid arthritis (RA) in a retrospective case–control study. Methods: RA patients who were followed for at least two consecutive years (RA) and a control group consisting of patients without RA but with similar background demographics (non-RA) were recruited and monitored. The prevalence of inc-BFF was compared between the two groups. Common potential risk factors in both groups and RA-specific factors within the RA group regarding inc-BFF were analyzed statistically. Results: A total of 278 patients were studied in each group. There was no significant difference in the prevalence of inc-BFF between the two groups. Presenting RA was not a major factor in developing inc-BFF. Higher Vz in the JIV, which reflects the difference in the involvement ratio between large and small joints, and higher PS-VAS showed significantly higher hazard ratios in a univariate model. Vz > 0.01, PS-VAS ≥ 25.5, and simplified disease activity index ≥ 2.11 at follow-up, along with PS-VAS at baseline > 21.0, are the key cutoff indices for RA-specific risk factors. When two of these factors were combined, the combination of Vz and PS-VAS at follow-up resulted in the highest hazard ratio (4.25; p < 0.001). Conclusions: These results suggest that combining Vz and PS-VAS is the key risk indicator for inc-BFF. Full article
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11 pages, 633 KB  
Article
Eight-Year Cohort Study Examining Bicycling-Related Maxillofacial Fractures and Factors Contributing to Injury
by Luis Miguel Gonzalez-Perez, Johan Wideberg and Carlos Alvarez-Delgado
Osteology 2025, 5(4), 34; https://doi.org/10.3390/osteology5040034 - 13 Nov 2025
Viewed by 1116
Abstract
Objectives: The aim of this study was to determine the epidemiological characteristics of bicycling-related maxillofacial fractures in a defined population and to identify factors contributing to these injuries. Methods: An 8-year cohort study was carried out, including all patients presenting with bicycling-related maxillofacial [...] Read more.
Objectives: The aim of this study was to determine the epidemiological characteristics of bicycling-related maxillofacial fractures in a defined population and to identify factors contributing to these injuries. Methods: An 8-year cohort study was carried out, including all patients presenting with bicycling-related maxillofacial fractures at a tertiary care center from 2017 through 2024. Data recorded for each patient included age, gender, date and cause of injury, contributing factors, type of facial fractures, other injuries, hospital stay, and helmet use. Statistical analysis was performed. Continuous variables were assessed for normality (Shapiro–Wilk test) and compared using the Mann–Whitney test. Categorical variables were analyzed with chi-square tests. A p-value ≤ 0.05 was considered statistically significant. Results: Out of 899 cycling accident patients seeking medical treatment, 122 (13%) sustained facial fractures, accounting for 4% of all facial fracture cases in our department during the study period. In our cohort, the male–female ratio was 2.6:1, and the mean age was 29.5 years (SD 12.8, range 13–77). Collision with another object/vehicle was the most common cause (64%), followed by isolated falls (36%). A total of 135 facial fractures were recorded (some patients had multiple fractures). Mandibular fractures were most frequent (49% of patients), followed by zygomatic (32%), orbital (13%), nasal (7%), maxillary (2%) and frontal (2%) fractures. Among mandibular injuries, condylar fractures were the most common subtype (63%). Dental injuries were found in 27% of patients. The most common dental trauma was tooth fracture (43% of those with dental injuries), followed by tooth luxation (32%) and tooth avulsion (25%). In 80% of cases involving dental injuries, the upper anterior teeth were involved. Concomitant injuries were present in 20% of patients, most often orthopedic limb injuries. Only 27% of patients reported always wearing a helmet, whereas 43% reported never having worn one. Conclusions: Bicycling-related facial injuries are a noteworthy subset of facial trauma. Missed or delayed diagnosis can lead to lasting deformities and functional issues. Preventive strategies—especially promoting helmet use and improving helmet design—along with broader safety measures are important to reduce the incidence and severity of these injuries. Full article
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14 pages, 2716 KB  
Brief Report
Acute Effects of Whole-Body Electromyostimulation Versus High-Intensity Resistance Training on Markers of Bone Turnover in Young Females—A Randomized Controlled Cross-Over Trial
by Sarah Stimpfig, Robert Kob, Matthias Kohl, Simon von Stengel, Barbara Obermayer-Pietsch, Michael Uder and Wolfgang Kemmler
Osteology 2025, 5(4), 33; https://doi.org/10.3390/osteology5040033 - 3 Nov 2025
Viewed by 1515
Abstract
The present study aimed to determine the acute effects of high-intensity dynamic resistance training (HI-DRT) and whole-body electromyostimulation (WB-EMS) on markers of bone formation and resorption in young healthy women. Using a crossover design, 17 students of dentistry (26.5 ± 4.0 years, 21.5 [...] Read more.
The present study aimed to determine the acute effects of high-intensity dynamic resistance training (HI-DRT) and whole-body electromyostimulation (WB-EMS) on markers of bone formation and resorption in young healthy women. Using a crossover design, 17 students of dentistry (26.5 ± 4.0 years, 21.5 ± 2.5 kg/m2) were randomly assigned to begin either with HI-DRT (five exercises, three sets to repetition maximum) or 20 min of non-superimposed, low-frequency (85 Hz), intermitted (6 s impulse/4 s impulse break) WB-EMS. The study outcome parameters were total Procollagen Type-1 N-Terminal Propeptide (P1NP) and Type-I Collagen Cross-Linked C-Telopeptide (CTX), which were sampled immediately prior to and 15 min post intervention. ANCOVA was applied to determine the main effects, i.e., differences in pre–post changes in CTX and P1NP between the interventions. No participant was lost to follow-up or reported adverse effects related to the exercises. Briefly, we observed significant differences (p = 0.019, d′ = 1.19) for changes in P1NP that were maintained in the HI-DRT (p = 0.446) and decreased in the WB-EMS group (p = 0.002). In contrast, we did not observe differences for HI-DRT- vs. WB-EMS-induced CTX changes (p = 0.509; d′ = 0.134). In summary, while HI-DRT provides significantly more favorable effects on bone formation markers compared to WB-EMS, the clinical significance of this finding in predicting the general effectiveness of an exercise protocol on bone strength remains to be determined. (Clinical trials.gov; registration date: 2025-02-06; ID: NCT06813092.) Full article
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15 pages, 787 KB  
Article
Associations of Dietary Indices with Hip Fracture in Postmenopausal Women and Subsequent Major Osteoporotic Fracture in the Japanese Clinical Setting
by Ichiro Yoshii, Naoya Sawada and Tatsumi Chijiwa
Osteology 2025, 5(4), 32; https://doi.org/10.3390/osteology5040032 - 18 Oct 2025
Viewed by 1017
Abstract
Background: Nutritional status affects bone fragility and related fractures. We investigated the relationships between bone fragility fractures and nutritional indicators, including the Geriatric Nutrition Risk Index (GNRI), Prognostic Nutrition Index (PNI), Control Nutrition Status (CONUT) score, and body mass index (BMI). Methods: Postmenopausal [...] Read more.
Background: Nutritional status affects bone fragility and related fractures. We investigated the relationships between bone fragility fractures and nutritional indicators, including the Geriatric Nutrition Risk Index (GNRI), Prognostic Nutrition Index (PNI), Control Nutrition Status (CONUT) score, and body mass index (BMI). Methods: Postmenopausal female outpatients aged 75 or older who experienced a hip fracture 2 to 4 weeks ago (hip fracture group; G-HF) or who have no history of hip fracture without secondary osteoporosis but have a T-score of bone mineral density less than −2.5 (primary osteoporosis group; G-POP) were studied using both cross-sectional and longitudinal methods. Variables, including blood test results, T-scores, and nutritional indicators at baseline, were compared between the two groups using a crude dataset and after propensity score matching (PSM). Correlations between hip fracture (HF) and baseline variables were statistically analyzed. The relationship between nutritional indicators and the development of subsequent major osteoporotic fractures (MOFs) after baseline was examined, and the relationship between dietary indicators and functional capacity was also investigated. Results: A total of 1201 patients were recruited from these 113 G-HF and 1088 G-POP groups (crude dataset), of whom 113 were included after PSM. There were many differences between the two groups using the crude dataset. However, no items were significantly different after PSM except for white blood cell count (WBC) and serum phosphorus levels. GNRI < 105.5 demonstrated a typical regression curve regarding prevalent hip fractures. Developing MOF was significantly correlated with T-scores in the femoral neck and the presence of a prevalent fragility fracture. PNI and GNRI demonstrated a significant correlation between functional capacity; however, there was no correlation with the development of MOF. Conclusions: GNRI < 105.5 was significantly correlated with the presence of hip fracture, although no significant association was found with the development of MOF. Full article
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13 pages, 2410 KB  
Article
Static and Dynamic Torque in the Modulation of the Caudal Vertebral Growth
by Xue-Cheng Liu, Robert Rizza, John Thometz, Andrew Allen, Derek Rosol, Channing Tassone, Paula North and Eric Jensen
Osteology 2025, 5(4), 31; https://doi.org/10.3390/osteology5040031 - 14 Oct 2025
Viewed by 1228
Abstract
Background/Objective: Major research demonstrates that longitudinal loading affects the vertebral growth and disc wedging in the scoliotic animal models; however, there is a scarcity of research on the effect of torque on the vertebral growth. Comparison of the effect of static and [...] Read more.
Background/Objective: Major research demonstrates that longitudinal loading affects the vertebral growth and disc wedging in the scoliotic animal models; however, there is a scarcity of research on the effect of torque on the vertebral growth. Comparison of the effect of static and dynamic torque on growth is also lacking. The aims of this study were to assess the morphological, histological, and immunohistochemical changes in caudal vertebrae of rats under controlled, static, and dynamic torque. Methods: Adjacent vertebral bodies of female Sprague-Dawley rats were loaded with a torque for 4 weeks. Six rats received a static torque of 1.25 Nm while 6 additional rats received a dynamic torque (2.4 Nm, 1.0 Hz for 15 min/time, 3 times/week). An additional 6 rats formed the control group and received no torque at all. All the rats were later sacrificed, and the tails for histological analysis, immunocytochemistry, and X-rays were obtained. Results: Among the three groups, there were significant differences in right side disc height and average disc height on the proximal vertebrae space in the coronal plane of the X-ray. There were significant differences in the physeal height between static torque and control, or between dynamic torque and control (p < 0.05). The proliferating cell nuclear antigens were detected with variable percentages in samples among the three physeal zones for all groups. Conclusions: Both static and dynamic torque induced asymmetric reduction in the physis and intervertebral disc, which may help to explain the development and vertebral tethering of scoliosis. Full article
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16 pages, 806 KB  
Systematic Review
Evaluating the Outcomes of Vertebral Biopsies Performed in Osteoporotic Vertebral Fractures: A Systematic Review and Meta-Analysis
by Halil Bulut, Chuck Lam, Veer Sheth, Iihan Ali, Christos Tsagkaris, Morgan Jones, Rajesh Botchu, Constantino Errani, Azmi Hamzaoglu and Korhan Ozkan
Osteology 2025, 5(4), 30; https://doi.org/10.3390/osteology5040030 - 11 Oct 2025
Viewed by 1750
Abstract
Background/Objectives: Osteoporotic vertebral fractures (OVFs) are common in older adults. While surgery is generally reserved for unstable or painful fractures, some OVFs conceal underlying malignancies, including metastatic and hematologic cancers. This study aimed to determine the pooled prevalence of unsuspected malignancy in patients [...] Read more.
Background/Objectives: Osteoporotic vertebral fractures (OVFs) are common in older adults. While surgery is generally reserved for unstable or painful fractures, some OVFs conceal underlying malignancies, including metastatic and hematologic cancers. This study aimed to determine the pooled prevalence of unsuspected malignancy in patients initially diagnosed with OVFs. Methods: A systematic search of PubMed and Scopus was conducted from inception to September 2025 in accordance with PRISMA guidelines. Eligible studies included adults with presumed OVFs who underwent vertebral biopsy and histopathological evaluation. Prevalence estimates were pooled using a random-effects model, and study quality was assessed with the Newcastle–Ottawa Scale. Results: Thirteen studies involving 3513 patients were included. The pooled prevalence of malignancy was 8.0% (95% CI: 5.4–10.6), comprising metastatic solid tumors (4.9%; 95% CI: 2.3–7.4) and multiple myeloma (2.6%; 95% CI: 1.3–3.9). Malignancy was detected in 2.7% (95% CI: 1.8–4.1) of routine biopsy cohorts versus 36.8% (95% CI: 22.1–54.4) of clinically suspected cases. Diagnostic yield exceeded 45% in patients selected by combined history, imaging, or known malignancy. No biopsy-related complications or procedure-related mortality were reported. Moderate heterogeneity was observed, mainly in suspected cohorts. Conclusions: Vertebral biopsy is a safe and diagnostically valuable procedure in vertebral compression fractures. Its yield ranges from about one in 30 patients in routine settings to nearly one in two in high-risk groups, underscoring the importance of structured patient selection to facilitate timely cancer detection and referral. Full article
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