Special Issue "Poxvirus Evolution"
Deadline for manuscript submissions: closed (28 February 2015).
Interests: microbial genomics and evolution; poxvirus evolution; virus taxonomy; bioinformatics; biomedical informatics
Interests: poxviruses; viral genomics and evolution; bioinformatics software development; virus virulence mechanisms
Since 1990, with the release of the Vaccinia-Copenhagen genome sequence, there has been a continuous and slowly increasing stream of genomic information available for members of the virus family, Poxviridae. In this Special Issue of Viruses, we hope to collect a series of articles and reviews that will highlight what we have learned from all these A, C, G and Ts—a current picture of the poxviruses, from an evolutionary standpoint. Although poxviruses are now in the intermediate size category for viruses, the puzzles around poxvirus evolution are clearly still large. These include the relationship of poxviruses to other viruses, the transfer of genes between poxvirus and host genomes, the evolution of widely disparate A+T% content in poxvirus genomes, the generation of multigene families, virus speciation events, changes to virus host range, evolution of poxvirus promoter classes, and the extent to which recombination has shaped poxvirus genome sequences. Answers to these questions do not merely provide information on poxvirus evolution as a lesson in history, but also focus on contemporary and future problems. For example, what is the likelihood that monkeypox, or some other poxvirus species, might evolve to become a new smallpox-like human disease? Or how can our understanding of virus host range adaptation be used to support the development of better vaccines or anti-cancer therapeutics? Especially important, as the destruction of the remaining stocks of variola virus continues to be debated, is the extent to which data derived from genome sequences and bioinformatics analysis can be used to answer remaining questions concerning smallpox biology? Our goal for this Special Issue is a compendium that reflects our current understanding of poxvirus evolution in a broad sense. We hope this information will support reconstruction of the evolutionary history of poxvirus species, enhance our current understanding of poxvirus biology, and help the research community make intelligent predictions of the possible evolutionary paths that these viruses might take.
Dr. Elliot J. Lefkowitz
Dr. Chris Upton
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- virus evolution
- virus genomics