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Viruses 2015, 7(3), 1100-1112;

The Origin of the Variola Virus

Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Novosibirsk 630090, Russia
JSC VECTOR-BEST, Novosibirsk 630559, Russia
Author to whom correspondence should be addressed.
Academic Editor: Elliot J. Lefkowitz
Received: 8 December 2014 / Revised: 14 January 2015 / Accepted: 26 February 2015 / Published: 10 March 2015
(This article belongs to the Special Issue Poxvirus Evolution)
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The question of the origin of smallpox, one of the major menaces to humankind, is a constant concern for the scientific community. Smallpox is caused by the agent referred to as the variola virus (VARV), which belongs to the genus Orthopoxvirus. In the last century, smallpox was declared eradicated from the human community; however, the mechanisms responsible for the emergence of new dangerous pathogens have yet to be unraveled. Evolutionary analyses of the molecular biological genomic data of various orthopoxviruses, involving a wide range of epidemiological and historical information about smallpox, have made it possible to date the emergence of VARV. Comparisons of the VARV genome to the genomes of the most closely related orthopoxviruses and the examination of the distribution their natural hosts’ ranges suggest that VARV emerged 3000 to 4000 years ago in the east of the African continent. The VARV evolution rate has been estimated to be approximately 2 × 10−6 substitutions/site/year for the central conserved genomic region and 4 × 10−6 substitutions/site/year for the synonymous substitutions in the genome. Presumably, the introduction of camels to Africa and the concurrent changes to the climate were the particular factors that triggered the divergent evolution of a cowpox-like ancestral virus and thereby led to the emergence of VARV. View Full-Text
Keywords: variola virus; orthopoxvirus; evolution; origin variola virus; orthopoxvirus; evolution; origin

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Babkin, I.V.; Babkina, I.N. The Origin of the Variola Virus. Viruses 2015, 7, 1100-1112.

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