Polyomaviruses
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".
Deadline for manuscript submissions: closed (15 December 2020) | Viewed by 68313
Special Issue Editors
Interests: polyomaviruses; cellular DNA synthesis regulation; DNA damage response; antiviral agents; flow and image cytometry of viral infection; response of stem cells/differentiated cells to polyomaviruses; cytogenetics; oncogenesis in vitro and in vivo
Special Issue Information
Dear Colleagues,
Murine polyomavirus was originally detected by Gross in 1953 as a filterable agent in leukemic extracts that could produce parotid tumors in mice. Stewart and Eddy isolated and characterized this agent, which was named “SE polyoma” due to the many types of tumors induced. In 1960, Sweet and Hilleman identified simian virus 40 in rhesus monkey cells and polio vaccines. As a eukaryotic virus, SV40 was utilized as a model for DNA replication, transcription, and oncogenesis, which eventually led to understanding of the initiation of tumors and the process of transformation by a virus. There are now over 100 species in the Polyomaviridae family. Of these, 14 species are known to infect humans, and several are clearly associated with disease in immunocompromised patients. Merkel cell polyomavirus (MCPyV) is responsible for most cases of Merkel cell carcinoma, which develops in the sun-exposed skin of older adults. BKPyV infection can result in nephropathy in renal transplant recipients and hemorrhagic cystitis following bone marrow transplantation. JCPyV is the causative agent of the potentially fatal demyelinating disease known as progressive multifocal leukoencephalopathy, which is a major concern for multiple sclerosis patients receiving immunotherapy. Evidence is also accumulating for involvement of BKPyV and JCPyV in human cancers.
In this Special Issue, we wish to explore areas of investigation that address current priorities in polyomavirus research which include, but are not limited to, the following:
- Development of pharmacological, genetic, and immunological therapeutics for pathogenic PyV infections;
- Definition of oncogenic mechanisms responsible for tumor formation in PyV-infected tissues;
- Identification of human and veterinary diseases associated with newly identified PyVs;
- Elucidation of the molecular and cellular biology of human and animal PyV infections to better understand unique and shared mechanisms.
Dr. John M. Lehman
Dr. Thomas D. Friedrich
Guest Editors
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Keywords
- polyomaviruses—animal & human
- treatment options
- mechanisms of oncogenesis
- mechanisms of viral pathogenesis
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