Special Issue "The Application of 3D Tissue Culture Systems in Virology"

A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 15 October 2020.

Special Issue Editor

Dr. Margaret Scull
Guest Editor
The University of Maryland, College Park, MD 20742, USA
Interests: airway biology; virus-host interactions; innate antiviral defense; species tropism; tissue engineering; primary cell systems

Special Issue Information

Dear Colleagues,

Since viruses are obligate intracellular parasites, the advent and subsequent innovations in cell culture technology have significantly impacted the field of virology. In recent years, the incorporation of tissue architecture and the integration of relevant cell–cell interactions, together with additional biochemical and mechanical cues that recapitulate the in vivo microenvironment, have yielded more physiologically relevant systems that bridge the gap between standard monolayer cell cultures and animal models. These novel models provide unique opportunities to further analyze virus–host interactions, culture previously hard-to-grow pathogens, identify novel therapeutic targets, and advance drug development.  

In this Special Issue, we will showcase recent advancements in the engineering and/or application of three-dimensional culture systems with emergent properties for virus infection. We welcome submissions reporting any aspect of virus–host interactions in these systems, especially those focusing on pathogens with patterns of infection that are not easily recapitulated in cell lines.

Dr. Margaret Scull
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • emergent properties
  • tissue engineering
  • organoids
  • spheroids
  • persistent infections
  • virus-host interactions
  • spatiotemporal dynamics
  • multiple organ components
  • high-throughput applications

Published Papers

This special issue is now open for submission.
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