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Veterinary Sciences
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Advances in Veterinary Pharmacology and Toxicology: From Molecule to Clinical...
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Advances in Veterinary Pharmacology and Toxicology: From Molecule to Clinical Practice

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Physiology, Pharmacology, and Toxicology".

Deadline for manuscript submissions: 10 September 2026 | Viewed by 746

Special Issue Editors

Prof. Dr. Shuiping Liu

E-Mail Website
Guest Editor
College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China
Interests: animal nutritional and metabolic diseases and poisoning diseases
Dr. Yunhuan Liu

E-Mail Website
Guest Editor
MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China
Interests: liver injury; gut–liver axis; gut microbiota; pig; mycotoxin
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advances in Veterinary Pharmacology and Toxicology: From Molecule to Clinical Practice focuses on the growing body of knowledge that connects molecular mechanisms with practical decision-making in veterinary medicine. The theme encompasses research exploring how drugs interact with biological systems, how pharmacokinetic and pharmacodynamic processes vary across species, and how these insights can refine therapeutic strategies. It also covers the study of toxic agents relevant to animals, including environmental chemicals, feed contaminants, and drug-related toxicities. By highlighting developments in analytical methods, biomarker identification, mechanistic toxicology, and translational approaches, this topic emphasizes the importance of integrating molecular evidence with clinical reasoning. The Special Issue aims to illuminate how advances in pharmacology and toxicology contribute to safer treatments, improved therapeutic efficacy, and better protection of animal health and welfare.

Prof. Dr. Shuiping Liu
Dr. Yunhuan Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • veterinary pharmacology
  • veterinary toxicology
  • drug action
  • pharmacokinetics
  • pharmacodynamics
  • toxicity mechanisms
  • biomarkers
  • therapeutic optimization
  • environmental toxicants
  • animal health and welfare

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

14 pages, 1082 KB  
Article
Pharmacokinetics of Lekethromycin in Swine Following Intramuscular Administration at Different Doses with a Single Intravenous Reference Dose for Absolute Bioavailability and Matrix Comparison
by Qinyao Wu, Zeyu Wen, Jinyan Meng, Runlin Yu, Nuoyu Xu, Lu Zhang, Degang Zhou and Xingyuan Cao
Vet. Sci. 2026, 13(3), 294; https://doi.org/10.3390/vetsci13030294 - 20 Mar 2026
Abstract
Lekethromycin (LKMS) is a novel macrolide veterinary antimicrobial. Its propensity for intracellular accumulation causes discrepancies between whole blood and plasma concentrations, complicating pharmacokinetic evaluations. This study compared the pharmacokinetic characteristics, dose proportionality, and bioavailability of LKMS in whole blood and plasma following intramuscular [...] Read more.
Lekethromycin (LKMS) is a novel macrolide veterinary antimicrobial. Its propensity for intracellular accumulation causes discrepancies between whole blood and plasma concentrations, complicating pharmacokinetic evaluations. This study compared the pharmacokinetic characteristics, dose proportionality, and bioavailability of LKMS in whole blood and plasma following intramuscular administration in pigs. Forty-two healthy pigs received LKMS via a single intravenous reference dose (5 mg/kg) for absolute bioavailability estimation or intramuscular (1, 2.5, 5, and 10 mg/kg) injection. Pharmacokinetic parameters were calculated using non-compartmental analysis, and dose proportionality was evaluated via a power model. LKMS exhibited rapid absorption and slow elimination, with a plasma half-life of 49.25 to 67.63 h. Whole blood exposure and peak concentrations were 1.5 to 3 times higher than in plasma, indicating extensive blood cell partitioning. As the intramuscular dose increased, the whole blood-to-plasma concentration ratio decreased from 2.83 to 1.15, suggesting a saturable cell uptake mechanism. Consequently, LKMS exhibited non-linear pharmacokinetics in whole blood but demonstrated linear, dose-proportional pharmacokinetics in plasma. Absolute bioavailability based on plasma ranged from 83.2% to 119.5%. Due to saturable blood cell binding, plasma is the optimal matrix for accurately evaluating LKMS systemic exposure and bioavailability in swine. Full article
(This article belongs to the Special Issue Advances in Veterinary Pharmacology and Toxicology: From Molecule to Clinical Practice)
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20 pages, 2924 KB  
Article
Computational Identification of Natural Inhibitors Targeting Fiber Proteins of FAdV-1 and FAdV-4 Through Integrated Virtual Screening and Molecular Dynamics Simulations
by Amina Kardoudi, Salaheddine Redouane, Abdelouaheb Benani, Faouzi Kichou, Charifa Drissi Touzani and Siham Fellahi
Vet. Sci. 2026, 13(3), 223; https://doi.org/10.3390/vetsci13030223 - 26 Feb 2026
Viewed by 341
Abstract
Fowl adenoviruses (FAdVs) represent a major threat to poultry health, with serotypes FAdV-1 and FAdV-4 causing adenoviral gizzard erosion (AGE) and hepatitis-hydropericardium syndrome (HHS), respectively. A wide variety of afflicted birds, including chicken, pigeon, and psittacine species, have been reported to carry aviadenoviruses. [...] Read more.
Fowl adenoviruses (FAdVs) represent a major threat to poultry health, with serotypes FAdV-1 and FAdV-4 causing adenoviral gizzard erosion (AGE) and hepatitis-hydropericardium syndrome (HHS), respectively. A wide variety of afflicted birds, including chicken, pigeon, and psittacine species, have been reported to carry aviadenoviruses. The disease is highly contagious and spreads rapidly between flocks and farms through vertical and horizontal transmission. In this study, we implemented a multi-stage computational drug-discovery pipeline to identify natural inhibitors of the viral fiber proteins for both FAdV-1 and FAdV-4. A curated library of 7523 natural compounds from the African Natural Products Database (ANPDB) and the South African Natural Compounds Database (SANCDB) was subjected to ADMET-based filtering, molecular docking, ADMET prediction, and 500 ns molecular dynamics simulations against four structural targets: Fiber-1 and Fiber-2 of FAdV-4, and the Short and Long Fibers of FAdV-1. Three ligands, ANPDB_6449 (−10.3 kcal/mol), ANPDB_2908 (−10.2 and −10.0 kcal/mol), and SANCDB_245 (−9.2 kcal/mol), consistently emerged as strong candidates across the entire computational workflow. While ANPDB_2908 demonstrated notable multi-target capability by binding to fiber proteins from both FAdV-1 and FAdV-4, ANPDB_6449 and SANCDB_245 exhibited strong serotype-specific potential, supported by stable interaction profiles and favorable drug-likeness characteristics. Together, these compounds highlight promising natural scaffolds for the development of targeted antiviral interventions against pathogenic FAdV serotypes. Full article
(This article belongs to the Special Issue Advances in Veterinary Pharmacology and Toxicology: From Molecule to Clinical Practice)
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15 pages, 10163 KB  
Article
Betulinic Acid Attenuates Lipopolysaccharide-Induced Kidney Inflammatory Injury by Suppressing PANoptosis in Weaned Piglets
by Yu Yang, Huan Yao, Jiayu He, Zhaoping Ou, You Huang, Wenyu Ba, Ziming Wang, Jiao Wu, Hongyi Ding, Zhuliang Tan, Quanwei Li, Jine Yi and Shuiping Liu
Vet. Sci. 2026, 13(3), 213; https://doi.org/10.3390/vetsci13030213 - 25 Feb 2026
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Abstract
In the intensive livestock farming industry, weaned piglets are highly prone to renal injury triggered by weaning stress, pathogen infection, and antibiotic abuse. This injury induces metabolic disorders and immunosuppression, severely restricting production efficiency. As a natural pentacyclic triterpene, betulinic acid (BA) exhibits [...] Read more.
In the intensive livestock farming industry, weaned piglets are highly prone to renal injury triggered by weaning stress, pathogen infection, and antibiotic abuse. This injury induces metabolic disorders and immunosuppression, severely restricting production efficiency. As a natural pentacyclic triterpene, betulinic acid (BA) exhibits notable biological activities, particularly in anti-inflammatory and antioxidant activities. However, its preventive potential against renal injury in piglets and the underlying mechanisms remain unclear. In this study, BA was administered as a long-term dietary pretreatment prior to lipopolysaccharide (LPS) challenge to evaluate its protective role in a preventive model of renal inflammatory injury in weaned piglets. BA pretreatment significantly mitigated pathological lesions, including renal tubular epithelial cell shedding and interstitial congestion, reduced the renal index, and decreased the concentrations of renal injury markers and serum UREA. In addition, BA pretreatment mitigated the renal oxidative stress and inflammatory injury induced by LPS in piglets. Molecular analyses showed that BA pretreatment was associated with decreased expression of key markers involved in apoptosis, necroptosis, and pyroptosis in renal tissue. Furthermore, protein–protein interaction analysis suggested potential associations between the HMGB1/TLR4/NF-κB signaling pathway and PANoptosis-related processes, providing exploratory and hypothesis-generating support for the proposed regulatory network. Collectively, these findings suggest that dietary BA pretreatment exerts a preventive effect against LPS-induced renal inflammatory injury in weaned piglets, potentially through modulation of HMGB1/TLR4/NF-κB-associated PANoptosis-related pathways, providing a theoretical basis for its application in livestock production. Full article
(This article belongs to the Special Issue Advances in Veterinary Pharmacology and Toxicology: From Molecule to Clinical Practice)
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