Viral Pathogenesis: Advances towards the Development of Therapeutics against HPV Infections and Diseases

Dear Colleagues,

While vaccines for the prevention of HPV infections are a well-established area, for a variety of reasons ranging from the large numbers of HPV types to vaccine resistance, HPV continues to be an ongoing human health issue. Therapies for ongoing HPV diseases are still in their rudimentary stages, generally relying on treatments that are not specific to the virus. When I was approached about the idea of a Special Issue on HPV therapeutics, I decided to expand the scope of this Issue to studies on basic processes of HPV infection and/or transformation that show clear implications for the potential development of therapeutics for either HPV infection or HPV transformation. Such areas could include: how HPV replicates its DNA in basal cells, how the viral DNA is amplified upon differentiation, how HPV attaches and enters cells, how viral oncoproteins interface with cellular factors, the most critical aspects of immunological clearance, progress in therapeutic HPV vaccines, as well as many other areas, all within the conceptual framework of how the interruption of processes of viral infection and transformation could be leveraged to provide therapeutic opportunities for HPV diseases.

Dr. Thomas Melendy
Guest Editor

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