Special Issue "Biomarkers and Immune Responses in Rheumatic Diseases: Current Concepts and Future Challenges"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cellular/Molecular Immunology".

Deadline for manuscript submissions: 31 December 2022.

Special Issue Editors

Dr. Rita Aguiar Moura
E-Mail Website1 Website2
Guest Editor
Instituto de Medicina Molecular João Lobo Antunes, 1649-004 Lisbon, Portugal
Interests: autoimmune diseases; rheumatoid arthritis; juvenile idiopathic arthritis; immune system; B cells; T cells; autoantibodies
Prof. Dr. João Eurico Fonseca
E-Mail Website
Guest Editor
1. Rheumatology Research Unit, Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
2. Rheumatology Department, Centro Hospitalar Universitário Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal
Interests: early arthritis; rheumatoid arthritis; biomarkers; prognosis; response to treatment; precision medicine; new targets
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Helena Canhao
E-Mail Website
Guest Editor
EpiDoC Unit, Comprehensive Health Research Center (CHRC), Nova Medical School, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal
Interests: epidemiology; predictors of disease and treatment response; interventions; innovation and new technologies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The importance of innate and adaptive immune responses in the development and progression of rheumatic diseases is well established. Rheumatic diseases are chronic inflammatory immune-mediated disorders that may affect the joints, muscles, bones and have a systemic and/ or organ-specific involvement. These conditions can have a major impact on patients’ quality of life, society and economic burden. Therefore, establishing an early diagnosis and initiating adequate treatment are fundamental for an effective disease management.

Biomarkers can be used as diagnostic tools, help to predict disease development in subjects at risk and provide useful prognostic information for therapeutic decisions in clinical practice. Serological and inflammatory parameters such as autoantibody levels, cytokines, chemokines, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are examples of biomarkers clinically relevant not only for the diagnosis, but also as indicators of treatment effectiveness during patient follow-up commonly used in rheumatic diseases. Nevertheless, the lack of validated specific disease biomarkers for each rheumatic disorder is still a current challenge.

The identification of new biomarkers in rheumatic diseases could have the potential to contribute to patient stratification, prognosis and treatment selection.  

The aim of this Special Issue is to collect original research articles and/ or reviews that focus on the potential use of novel or existant biomarkers and immunopathogenesis of rheumatic diseases, which might provide new sustainable evidence for an accurate diagnosis and treatment management. Research areas may include (but are not limited to) the following disease topics:  

I.         Rheumatoid arthritis

II.        Diffuse connective tissue diseases

III.       Spondyloarthritis

IV.       Vasculitis

V.        Juvenile idiopathic arthritis

VI.       Osteoporosis

VII.      Osteoarthritis

We look forward to receiving your contributions. 

Dr. Rita Aguiar Moura
Prof. Dr. João Eurico Fonseca
Prof. Dr. Helena Canhao
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • rheumatic diseases
  • biomarkers
  • immunopathogenesis
  • diagnosis
  • prognosis
  • disease-modifying anti-rheumatic drugs (DMARDs)

Published Papers

This special issue is now open for submission.
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