Development of Vaccines against Bacterial Infections

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccines against Tropical and other Infectious Diseases".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 1911

Special Issue Editors


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Guest Editor
Department of Veterinary Medicine, Jeonbuk National University, Jeonju, Republic of Korea
Interests: veterinary vaccines; delivery systems; Salmonella vector vaccines; Salmonella in cancer therapy; oral mRNA vaccine; Salmonella pathophysiology; Salmonella mediated immunotherapy; antibacterial-antiviral peptides and drugs
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Republic of Korea
Interests: veterinary vaccines; delivery systems; Salmonella vector vaccines; Salmonella in cancer therapy; oral mRNA vaccine; Salmonella pathophysiology; Salmonella mediated immunotherapy; antibacterial-antiviral
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The Special Issue titled "Development of Vaccines against Bacterial Infections" aims at providing a comprehensive overview of the current state of research in the field of vaccine development against bacterial infections. Bacterial infections continue to pose significant challenges to public health worldwide, with the emergence of antibiotic resistance. The re-emergence of vaccine-preventable diseases during the post-antibiotic era highlights the urgent need for novel vaccine strategies. This Special Issue will cover a wide range of topics related to bacterial vaccine development, including advances in vaccine design, mechanisms of bacterial pathogenesis, the preclinical and clinical evaluation of vaccine candidates, the use of bacteria in vaccine development, and strategies for vaccine delivery and formulation. Contributions from leading researchers and experts in the field will provide insights into the latest scientific advancements, challenges, and opportunities in the development of vaccines against bacterial infections. The goal of this Special Issue is to foster collaboration and knowledge exchange among scientists, clinicians, policymakers, and industry stakeholders to accelerate the development of effective vaccines that can mitigate the burden of bacterial diseases and improve global health outcomes.

Prof. Dr. John Hwa Lee
Prof. Dr. Amal Senevirathne
Guest Editors

Manuscript Submission Information

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Keywords

  • novel vaccine formulations
  • bacterial pathogenesis mechanisms
  • immunogenicity assessment
  • vaccine efficacy studies
  • next-generation vaccine platforms
  • targeted antigen design
  • novel adjuvants
  • vaccine clinical trials
  • vaccine delivery systems
  • vaccine cross-protection

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Published Papers (1 paper)

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Review

26 pages, 2074 KiB  
Review
Q Fever Vaccines: Unveiling the Historical Journey and Contemporary Innovations in Vaccine Development
by Magdalini Christodoulou and Dimitrios Papagiannis
Vaccines 2025, 13(2), 151; https://doi.org/10.3390/vaccines13020151 - 31 Jan 2025
Viewed by 1527
Abstract
Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii that presents significant challenges for global public health control. Current prevention relies primarily on the whole-cell vaccine “Q-VAX”, which despite its effectiveness, faces important limitations including pre-screening requirements and [...] Read more.
Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii that presents significant challenges for global public health control. Current prevention relies primarily on the whole-cell vaccine “Q-VAX”, which despite its effectiveness, faces important limitations including pre-screening requirements and reactogenicity issues in previously sensitized individuals. This comprehensive review examines the complex interplay between pathogen characteristics, host immune responses, and vaccine development strategies. We analyze recent advances in understanding C. burnetii’s molecular pathogenesis and host–pathogen interactions that have informed vaccine design. The evolution of vaccine approaches is evaluated, from traditional whole-cell preparations to modern subunit, DNA, and multi-epitope designs. Particular attention is given to innovative technologies, including reverse vaccinology and immunoinformatics, that have enabled the identification of novel antigenic targets. Recent clinical data demonstrating the safety and immunogenicity of next-generation vaccine candidates are presented, alongside manufacturing and implementation considerations. While significant progress has been made in overcoming the limitations of first-generation vaccines, challenges remain in optimizing immunogenicity while ensuring safety across diverse populations. This review provides a critical analysis of current evidence and future directions in Q fever vaccine development, highlighting promising strategies for achieving more effective and broadly applicable vaccines. Full article
(This article belongs to the Special Issue Development of Vaccines against Bacterial Infections)
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