Enteroviruses: Advances in Virology, Pathogenesis, and Vaccine R&D

Dear Colleagues,

Enteroviruses are a diverse group of RNA viruses within the Picornaviridae family, responsible for various human diseases, from mild respiratory and gastrointestinal illness to severe neurological syndromes such as aseptic meningitis and poliomyelitis. Specific serotypes, such as enterovirus-71 (EV-71) and coxsackieviruses, are significant causes of hand, foot, and mouth disease (HFMD), which poses an important public health burden in many regions, especially in young children. The development of the EV-71 vaccine in China has demonstrated the feasibility and impact of vaccination, yet effective vaccines for most enterovirus serotypes remain limited. Continued research on enterovirus biology, epidemiology, and vaccine development is essential for improving global disease prevention and control.

This Special Issue aims to bring together the latest research and scientific advances on enteroviruses, covering virology, molecular epidemiology, viral pathogenesis, immunological responses, and vaccine R&D. The topic aligns closely with the scope of Vaccines, particularly in supporting innovative strategies for vaccine development and global immunization efforts. We hope to provide a timely platform for researchers to share their findings and promote further collaboration in this field.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

• Enterovirus classification, phylogenetics, genomic analysis, and evolutionary dynamics;
• Molecular and cellular mechanisms of viral pathogenesis;
• Surveillance systems, outbreak investigation, and transmission patterns;
• Host immune responses and correlates of protection;
• Vaccine development and evaluation, especially multivalent (multi-serotype) vaccines and novel platforms such as mRNA and virus-like particle (VLP) technologies;
• Epidemiological trends and public health strategies;
• Studies focusing on poliovirus, EV-71, coxsackieviruses, and other clinically relevant enteroviruses.

We look forward to receiving your contributions.

Dr. Yang Song
Dr. Naiying Mao
Dr. Jinbo Xiao
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• enteroviruses
• coxsackievirus
• poliovirus
• echovirus
• HFMD
• viral pathogenesis
• molecular epidemiology
• immunology
• vaccines
• vaccine development