Vaccine Hesitancy and Acceptance: A Public Health Perspective

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Human Vaccines and Public Health".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1302

Special Issue Editors


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Guest Editor
College of Medicine, Central Michigan University, Midland, MI, USA
Interests: health sciences; systematic reviews; infodemics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
College of Medicine, Central Michigan University, Midland, MI, USA
Interests: infectious diseases; virology; microbiology

Special Issue Information

Dear Colleagues,

Vaccination has been one of the most effective public health interventions, significantly reducing the burden of infectious diseases worldwide. Vaccines have eradicated smallpox, nearly eliminated polio, and substantially lowered the incidence of measles, mumps, and rubella. Despite these successes, vaccine hesitancy remains a critical public health challenge. Vaccine hesitancy is a multifaceted issue influenced by factors such as misinformation, cultural beliefs, political ideologies, and individual experiences with healthcare systems. The rise of social media has further exacerbated the spread of vaccine misinformation, leading to increased skepticism toward vaccines. Understanding the causes of vaccine hesitancy and promoting strategies to improve vaccine acceptance are crucial for maintaining herd immunity and preventing the resurgence of vaccine-preventable diseases. Research in the area of vaccine hesitancy and acceptance is critical to developing effective interventions. Given the ongoing threat of emerging infectious diseases and global pandemics, addressing vaccine hesitancy is essential for individual and public health and a cornerstone of global health security.

This Special Issue will examine what drives vaccine hesitancy and what is essential for developing effective public health strategies related to vaccines, as well as evaluate vaccine hesitancy on public health outcomes such as vaccine-preventable diseases and lowered herd immunity. This issue will also address disparities in vaccine acceptance and assess the importance of communication in vaccine hesitancy. It will also explore approaches for improving vaccine acceptance. Its additional aims are identifying and promoting interventions that increase vaccine acceptance in the public health framework. Additionally, it will address vaccine uptake among marginalized populations and the importance of access to vaccines.

We look forward to receiving your contributions. 

Dr. Neli Ragina
Dr. Michael J. Conway
Guest Editors

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Keywords

  • vaccine hesitancy
  • vaccine acceptance
  • public health
  • vaccine uptake
  • misinformation
  • risk perception
  • health communication
  • immunization rates
  • herd immunity
  • behavioral determinants
  • social determinants
  • trust in healthcare
  • vaccine misinformation
  • vaccine education
  • vaccine refusal
  • vaccine policy
  • health disparities

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Published Papers (1 paper)

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21 pages, 1061 KiB  
Systematic Review
The Relationship Between Postpartum Depression and Timely Child Vaccination: A Systematic Review
by Julien Robitaille, Kayla Esser, Catherine King, Julie Leask, Kerrie Wiley, Simone Vigod, Gary Rodin, Shelly Bolotin and Gilla K. Shapiro
Vaccines 2025, 13(3), 222; https://doi.org/10.3390/vaccines13030222 - 24 Feb 2025
Viewed by 766
Abstract
Background/Objective: Vaccines administered during early childhood rely on caregivers being aware, willing, and able to vaccinate their child. Postpartum depression (PPD) could adversely affect a parent’s ability to undertake such preventive care. This systematic review sought to examine the relationship between PPD and [...] Read more.
Background/Objective: Vaccines administered during early childhood rely on caregivers being aware, willing, and able to vaccinate their child. Postpartum depression (PPD) could adversely affect a parent’s ability to undertake such preventive care. This systematic review sought to examine the relationship between PPD and timely vaccination in children. Methods: We systematically searched eight databases (MEDLINE ALL, Embase, PsycINFO, CINAHL, LILACS, Web of Science, Sociological Abstracts, and Scopus) from database inception to September 2023. We also reviewed reference lists of included studies. We included primary studies that examined the association between PPD and child vaccination status between birth and 24 months. Two researchers independently extracted data and assessed study quality. Results: In total, 5504 records were screened for eligibility. Of the 50 articles included in full-text assessment, 12 met the eligibility criteria. Most studies (83%) were conducted in high-income countries, with a minority (17%) from lower-middle income countries (LMICs). The sample size of studies varied from <500 (33%) to >450,000 participants (17%). Overall, six studies (50%) found a relationship between maternal PPD and child vaccinations not completed on time, and six (50%) found no relationship. In most studies that were assessed to be of high-quality and found a relationship, the magnitude of the absolute risk was small. Conclusions: We detected significant heterogeneity among the included studies. Further high-quality research using standardized definitions is needed to determine whether parents with PPD may require tailored strategies and supports that consider their symptoms and specific barriers to vaccination. Full article
(This article belongs to the Special Issue Vaccine Hesitancy and Acceptance: A Public Health Perspective)
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