Special Issue "Human Cytomegalovirus: Recent Advances, Novel Targets and Vaccines"

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Cellular/Molecular Immunology".

Deadline for manuscript submissions: 10 April 2022.

Special Issue Editors

Dr. Sébastien Hantz
E-Mail Website
Guest Editor
RESINFIT, CHU Limoges, Inserm, University of Limoges, UMR_S1092, 87000 Limoges, France
Interests: cytomegalovirus; antivirals; human papillomavirus
Dr. Gaëtan Ligat
E-Mail Website
Guest Editor
Institute for Viral and Liver Disease, Inserm, University of Strasbourg, UMR_S1110, F-67000 Strasbourg, France
Interests: molecular virology; targets; drugs; host-virus interactions; human cytomegalovirus; hepatitis B virus

Special Issue Information

Dear Colleagues, 

Human cytomegalovirus (HCMV) is the most common infectious cause of congenital malformations, with developmental delay, sensorineural hearing loss and fetal death in 10-15% of cases. HCMV can also cause severe disease in immunocompromised patients (HIV positive and solid organ transplant or hematopoietic stem cell transplant recipients). Currently, there is no approved vaccine for the prevention of CMV infection. Three major molecules, ganciclovir (GCV), cidofovir (CDV) and foscarnet (FOS), all targeting the HCMV polymerase pUL54, are routinely used for prevention and treatment of HCMV infection in the transplant setting. In these patients, emergence of CMV drug-resistance is a growing therapeutic challenge that is added to the toxicity of the molecules. As they have hematologic and renal toxicity, these drugs are not recommended for administration in pregnant women and their use could be limited in transplant setting. Developing low toxicity drugs and vaccines are accordingly a major public health priority.

This Special Issue focuses on the recent development of novel targets, HCMV drugs, on existing vaccines in development, and recent novel advances such as mRNA prophylactic vaccines.

Dr. Sébastien Hantz
Dr. Gaëtan Ligat
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Herpesviruses
  • Human cytomegalovirus
  • Vaccines
  • Targets
  • Drugs

Published Papers (1 paper)

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Towards a Prophylactic Vaccine for the Prevention of HCMV Infection
Vaccines 2021, 9(9), 968; https://doi.org/10.3390/vaccines9090968 - 29 Aug 2021
Viewed by 554
Human cytomegalovirus (HCMV) or human herpesvirus 5, is a ubiquitous human herpesvirus, which can cause severe disease in immunocompromised patients (AIDS patients and solid organ transplant or hematopoietic stem cell transplant recipients) [...] Full article
(This article belongs to the Special Issue Human Cytomegalovirus: Recent Advances, Novel Targets and Vaccines)
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