Maternal and Infant Vaccines

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 20 September 2026 | Viewed by 1003

Special Issue Editors


E-Mail Website
Guest Editor
1. Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, Australia
2. Vaccinology and Immunology Research Trials Unit, Women’s and Children’s Hospital, Adelaide, SA 5006, Australia
Interests: health in pregnancy; maternal vaccination; infant health

E-Mail Website
Guest Editor
1. Adelaide Medical School and The Robinson Research Institute, The University of Adelaide, Adelaide, Australia
2. Vaccinology and Immunology Research Trials Unit, Women’s and Children’s Hospital, Adelaide, SA 5006, Australia
Interests: vaccine effectiveness; vaccine attitudes; disease burden

Special Issue Information

Dear Colleagues,

Pregnancy and infancy are periods of increased vulnerability to infection. Vaccinating women during pregnancy has been shown to be effective in protecting against infections, while also providing protection for the fetus and the infant during early life. Vaccinating infants can be effective in protecting them from infections. This Special Issue on ‘Maternal and Infant Vaccines’ aims to collect recent evidence on vaccines administered to pregnant women and babies in the first year of life. We are pleased to invite you to submit manuscripts to this Special Issue related to the following themes:

  1. Uptake, safety and effectiveness of current vaccines;
  2. Immunogenicity of vaccines;
  3. Potential future vaccines that are currently undergoing clinical trials.

We look forward to receiving your contributions.

Dr. Prabha Andraweera
Dr. Bing Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • maternal vaccines
  • infant vaccines
  • immunogenicity
  • effectiveness
  • vaccine uptake
  • safety

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

18 pages, 1308 KB  
Article
Safety, Tolerability, and Immunogenicity of RSVpreF Vaccine in Pregnant Individuals Living with HIV
by Landon Myer, Emily Wasserman, Saiqa Tabasum, Emma Shittu, Yanping Liu, Lisa Jose, Elizea Horne, Robert S. Moraba, Agatha Wilhase, Heather J. Zar, Nazreen Hussen, Mokgadi S. Mogashoa, Mookho Malahleha, Shabir A. Madhi, Uzma N. Sarwar, Hasra Snaggs, Rahsan Erdem, David Radley, Elena V. Kalinina, Barbara A. Pahud, Maria Maddalena Lino, Olympia Evdoxia Anastasiou, Kena A. Swanson, Annaliesa S. Anderson, Alejandra Gurtman and Iona Munjaladd Show full author list remove Hide full author list
Vaccines 2025, 13(12), 1218; https://doi.org/10.3390/vaccines13121218 - 1 Dec 2025
Viewed by 513
Abstract
Background/Objectives: HIV-exposed uninfected (HEU) infants experience increased severe respiratory syncytial virus lower respiratory tract illness (RSV-LRTI) rates compared with HIV-unexposed infants. Maternal bivalent RSVpreF vaccination can prevent infant RSV-LRTI but data from HEU infants are lacking. Methods: This phase 3 randomized, double-blinded trial [...] Read more.
Background/Objectives: HIV-exposed uninfected (HEU) infants experience increased severe respiratory syncytial virus lower respiratory tract illness (RSV-LRTI) rates compared with HIV-unexposed infants. Maternal bivalent RSVpreF vaccination can prevent infant RSV-LRTI but data from HEU infants are lacking. Methods: This phase 3 randomized, double-blinded trial assessed RSVpreF safety and immunogenicity in pregnant participants from South Africa living with HIV and their infants. Maternal participants with stable HIV disease taking antiretroviral therapy received RSVpreF or placebo (24–36 weeks’ gestation). Primary safety endpoints included reactogenicity through 7 days after vaccination (maternal participants), adverse events (AEs) through 1 month after vaccination (maternal participants) or birth (infants), and serious AEs (SAEs) throughout the study (maternal participants) or through 6 months after birth (infants). Immune responses were evaluated by 50% RSV-A and RSV-B neutralizing titers prevaccination and at delivery (maternal participants) or birth (infants). Results: Overall, 343 maternal participants received RSVpreF (n = 172) or placebo (n = 171). Most reactogenicity events were mild/moderate. AEs and SAEs were generally reported at similar frequencies in maternal RSVpreF and placebo groups including percentages of hypertensive disorders of pregnancy. There were no safety concerns in infants; percentages of reported AEs and SAEs were generally similar between RSVpreF and placebo groups and no difference in preterm birth. RSVpreF elicited high maternal neutralizing RSV-A and RSV-B immune responses, with efficient RSV antibody transplacental transfer to infants demonstrated by levels greater than the placebo group at birth (geometric mean ratios (GMRs) of RSVpreF to placebo were 7.8 for RSV-A and 6.8 for RSV-B) and by comparison with a cohort of HIV-unexposed infants from the pivotal phase 3 efficacy trial (GMRs of HEU to HIV-unexposed infants were 0.86 for RSV-A and 0.72 for RSV-B). Conclusions: These results support maternal RSVpreF vaccination among those living with stable HIV for preventing RSV-LRTI in HEU infants. (NCT06325657). Full article
(This article belongs to the Special Issue Maternal and Infant Vaccines)
Show Figures

Figure 1

Back to TopTop