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Vaccines
Special Issues
Influenza Vaccines and Influenza Vaccination in Europe
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Influenza Vaccines and Influenza Vaccination in Europe

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Influenza Virus Vaccines".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1085

Special Issue Editor

Dr. George Kassianos

E-Mail Website
Guest Editor
1. National Immunisation Lead Royal College of General Practitioners, London, UK
2. The British Global & Travel Health Association, Bath, UK
Interests: vaccines and immunology; influenza; travel health; cardiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

For this Special Issue, we welcome both original research and comprehensive review articles that focus on influenza vaccines used in Europe. We are interested in studies addressing the efficacy and effectiveness of influenza vaccines, vaccination rates, vaccine safety, and targeted vaccination within the population. Contributions focusing on antivirals and current and future influenza vaccine technologies are also welcome.

Dr. George Kassianos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vaccines
  • vaccine design
  • influenza
  • vaccination rates
  • vaccine efficacy
  • effectiveness
  • vaccine safety
  • vaccine development
  • adjuvant
  • recombinant influenza vaccine
  • cell-based
  • egg-derived
  • mRNA
  • vaccination strategies
  • vaccine response
  • antivirals

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 3006 KB  
Article
Metabolic Regulation of Influenza Vaccine Responses in Racially Diverse Hispanics
by Daniela Frasca, Maria Romero and Suresh Pallikkuth
Vaccines 2025, 13(9), 938; https://doi.org/10.3390/vaccines13090938 - 2 Sep 2025
Viewed by 673
Abstract
Background: Racial and ethnic differences in vaccine responses, particularly within Hispanic populations, remain underexplored. Disparities in immune function may be influenced by metabolic and inflammatory mechanisms. Methods: The current study investigated humoral immune responses to influenza vaccination in a diverse cohort of Hispanic [...] Read more.
Background: Racial and ethnic differences in vaccine responses, particularly within Hispanic populations, remain underexplored. Disparities in immune function may be influenced by metabolic and inflammatory mechanisms. Methods: The current study investigated humoral immune responses to influenza vaccination in a diverse cohort of Hispanic individuals from South Florida, encompassing both White and Black Hispanics. Antibody responses were assessed post-vaccination, and B cell phenotypes were analyzed to evaluate inflammatory and metabolic characteristics. In vitro experiments were conducted to determine whether blocking metabolic pathways could alter the inflammatory phenotype of B cells. Data were analyzed using an unpaired Student’s t-test (two-tailed), and correlation analysis was conducted with Pearson correlation. Results: Our findings indicated that Black Hispanic individuals exhibited significantly reduced antibody responses compared to White Hispanics (p < 0.01) following influenza vaccination. This diminished humoral response correlated with inversely with serum LDH (r = −0.58; p = 0.0005) and other intrinsic inflammatory phenotypes in blood-derived B cells and was supported by changes in metabolic activity. In vitro blockade of metabolic pathways effectively reduced the inflammatory phenotype of B cells from Black Hispanic individuals, suggesting a mechanistic link between metabolic dysfunction and impaired vaccine-induced immunity. Conclusion: This study is the first to reveal racial disparities in influenza vaccine responses within a Hispanic population, highlighting reduced antibody production in Black Hispanics. These findings suggest that metabolically driven B cell inflammation may play a critical role and point to potential therapeutic strategies to address disparities in vaccine-induced immunity. Full article
(This article belongs to the Special Issue Influenza Vaccines and Influenza Vaccination in Europe)
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