Application of Protein Toxins as Cell Biological and Pharmacological Tools
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 51523
Special Issue Editor
Interests: endocytosis; intracellular trafficking; protein toxins; lectins; glycobiology; glycosphingolipids; lipid rafts; membrane compartmentalization; intracellular delivery; membrane translocation; immunotherapy; tumor targeting
Special Issue Information
Protein toxins from bacteria and plants are a serious threat to human and animal health. However, because of their intimate interactions with host cells, they have also become valuable tools to molecularly dissect cell biological functions that range from endocytosis and intracellular trafficking to cell signaling and apoptosis. Several characteristics such as ease for biochemical handling and the robustness of phenotypes are responsible for their success as cell biological tools. The in-depth understanding of their activities has, in turn, also attracted attention to their use as pharmacological tools to manipulate cellular processes that misfunction in disease situations or that can be targeted for therapeutic intervention. Cancer immunotherapy by immunotoxins or toxin subunit-based vaccines are only some of the many possibilities for using toxins in biomedical research. In this special issue of Toxins, primary research papers and review articles are assembled that address the aspects that are summarized above. The reader is thereby provided with an up-to-date perspective on some of the most recent and dynamic contributions of toxins to fundamental cell biology and applied cellular pharmacology research.
Dr. Ludger Johannes
Guest Editor
Manuscript Submission Information
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Keywords
- endocytosis
- intracellular trafficking
- lipid domains
- apoptosis
- signaling
- broad spectrum inhibitors
- immunotherapy
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