Special Issue "Production of Toxins by Peptide Synthetases and Polyketide Synthases"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 2012
Interests: cyanobacteria; cyanotoxins; analysis; toxicology; exposure routes
Special Issues, Collections and Topics in MDPI journals
Many fungal and bacterial, including cyanobacterial, secondary metabolites and toxins, are synthesized by enzymes through non-ribosomal peptide synthesis (NRPS). These enzymatic systems can involve peptide synthetases and polyketide synthases as examples. Understanding these enzyme systems has led to great advancements in risk assessment and in how toxin synthesis is controlled within microbial cells. As such systems encompass large multigene operons, the diversity within cyanobacteria and the cyanobacterial toxin variants that may be produced could be better understood through analysis of these genetic components. This Special Issue looks to understand the diversity of genes pertaining to toxin production using NRPS. This may involve mechanisms of understanding transcription and translation of the enzyme systems, construction and activity of the enzymes themselves and inhibitors and other mechanisms to stop toxin production via NRPS. Submissions can also include technical and industrial applications of these enzyme systems to produce toxins and novel therapeutics.
Dr. James S. Metcalf
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.