Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.5
4.2
Journals
Toxins
Special Issues
Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine...
share announcement

Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine Processing

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 9767

Special Issue Editors

Prof. Dr. Meihua Yang

E-Mail Website
Guest Editor
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Xibeiwang, Haidian District, Beijing 100193, China
Interests: rapid detection; toxicity and risk assessment of (modified) mycotoxins in herbal medicines
Prof. Dr. Jin Mao

E-Mail Website
Guest Editor
Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, No.2, Xudong Second Road, Wuhan 430062, China
Interests: green prevention & control of mycotoxin and toxigenic fungi
Dr. Hao Zhang

E-Mail Website
Guest Editor
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agriculture Sciences, Beijing, China
Interests: rapid detection and monitoring of toxic fungi and toxins
Dr. Veronica Maria Teresa Lattanzio

E-Mail Website1 Website2
Guest Editor
Institute of Sciences of Food Productions, National Research Council of Italy, Via Amendola 200/O, 70126 Bari, Italy
Interests: food safety; food safety policy; development and validation of analytical methods for mycotoxin detection based either on mass spectrometry techniques and immunoassays, including organization of collaborative trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mycotoxin contamination of food commodities and herbal medicines is a major safety challenge to human health. The crops and medicinal plants could be infected with mycotoxin-producing fungi during growth, processing, transportation, or storage if the conditions are favorable to fungi. Toxigenic fungi can grow and produce mycotoxins in plant material during the whole production chain. Many mycotoxins are stable under processing conditions and thus remain in the final products. Notably, in some cases, processing may increase the toxicity of mycotoxins. This might also apply when new technologies are implemented to re‐use side streams from the food industry to obtain nutritious but low‐cost sources of, for instance, feed for livestock. If and how mycotoxins accumulate in these by‐products is still unknown.

The knowledge of the processing effects is not only important to recognize their effects on mycotoxins distribution and/or chemical modification, but can also be employed in the decontamination or prevention of contamination efforts, such as segregation, milling, cleaning/washing, sieving, dehulling et al.

In this Special Issue, we invite the submissions and look forward to your contributions to advance the available knowledge on mycotoxin fate during processing including their evaluation as a circularity-related food safety issue. Studies describing the contamination level, transfer rule, toxin-producing mechanism, health risk assessment, decontamination or prevention of mycotoxins (toxigenic fungi) and in vivo and in vitro metabolic processes of mycotoxins in food and herbal medicines will be welcomed!

Prof. Dr. Meihua Yang
Prof. Dr. Jin Mao
Dr. Hao Zhang
Dr. Veronica Maria Teresa Lattanzio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mycotoxins
  • food
  • herbal medicine
  • processing
  • transfer rule
  • toxin-producing mechanism
  • contamination level
  • health risk assessment
  • in vivo and in vitro metabolic processes
  • circularity of resources

Published Papers (5 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

16 pages, 6765 KiB  
Article
A Dynamic and Pseudo-Homogeneous MBs-icELISA for the Early Detection of Aflatoxin B1 in Food and Feed
by Lin Wei, Deyan Xu, Bei Yuan, Chengchen Pang, Haitao Xu, Kunying Nie, Qingqing Yang, Sibel A. Ozkan, Yanyan Zhang, Yemin Guo and Xia Sun
Toxins 2023, 15(11), 660; https://doi.org/10.3390/toxins15110660 - 16 Nov 2023
Cited by 1 | Viewed by 1200
Abstract
Aflatoxin B1 (AFB1) is one of the most toxic and harmful fungal toxins to humans and animals, and the fundamental way to prevent its entry into humans is to detect its presence in advance. In this paper, the monoclonal antibody [...] Read more.
Aflatoxin B1 (AFB1) is one of the most toxic and harmful fungal toxins to humans and animals, and the fundamental way to prevent its entry into humans is to detect its presence in advance. In this paper, the monoclonal antibody mAbA2-2 was obtained via three-step sample amplification and multi-concentration standard detection using a subcloning method based on the limited dilution method with AFB1 as the target. A dynamic and pseucdo-homogeneous magnetic beads enzyme-linked immunosorbent assay (MBs-icELISA) was established using the prepared antibody as the recognition element and immunomagnetic beads as the antigen carrier. The MBs-icELISA showed good linear correlation in the concentration range of 0.004–10 ng/mL with R2 = 0.99396. The limit of detection (LOD) of the MBs-icELISA for AFB1 was 0.0013 ng/mL. This new ELISA strategy significantly shortened AFB1 detection time through improved sensitivity compared to the conventional ELISA method. Full article
(This article belongs to the Special Issue Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine Processing)
►▼ Show Figures

Figure 1

11 pages, 2739 KiB  
Article
Multicolor Visual Detection of Deoxynivalenol in Grain Based on Magnetic Immunoassay and Enzymatic Etching of Plasmonic Gold Nanobipyramids
by Rui Guo, Yue Ji, Jinnan Chen, Jin Ye, Baoxia Ni, Li Li and Yongtan Yang
Toxins 2023, 15(6), 351; https://doi.org/10.3390/toxins15060351 - 23 May 2023
Cited by 4 | Viewed by 1185
Abstract
In this study, a multicolor visual method based on a magnetic immunoassay and enzyme-induced gold nanobipyramids (Au NBPs) etching was developed for deoxynivalenol (DON) detection. The magnetic beads modified with high affinity DON monoclonal antibodies were used as a carrier for target enrichment [...] Read more.
In this study, a multicolor visual method based on a magnetic immunoassay and enzyme-induced gold nanobipyramids (Au NBPs) etching was developed for deoxynivalenol (DON) detection. The magnetic beads modified with high affinity DON monoclonal antibodies were used as a carrier for target enrichment and signal transformation and the Au NBPs with excellent plasmonic optical properties were served as enzymatic etching substrates. The oxidation state TMB, which was generated through catalysis of horseradish peroxidase (HRP), induced the etching of plasmonic Au NBPs, resulting in the longitudinal peak blue-shift of local surface plasmon resonance (LSPR). Correspondingly, Au NBPs with various aspect ratios displayed a variety of individual colors which were visualized by the naked eye. The LSPR peak shift was linearly related to the DON concentration in the range of 0~2000 ng/mL and the detection limit was 57.93 ng/mL. The recovery for naturally contaminated wheat and maize at different concentrations ranged from 93.7% to 105.7% with a good relative standard deviation below 11.8%. Through observing the color change in Au NBPs, samples with overproof DON could be screened preliminarily by the naked eye. The proposed method has the potential to be applied in on-site rapid screening of mycotoxins in grain. In addition, the current multicolor visual method only used for the simultaneous detection of multiple mycotoxins is in urgent need of a breakthrough to overcome the limitation of single mycotoxin detection. Full article
(This article belongs to the Special Issue Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine Processing)
►▼ Show Figures

Figure 1

12 pages, 2203 KiB  
Article
Automatic Pretreatment of Dispersive Liquid Liquid Microextraction Based on Immunomagnetic Beads Coupled with UPLC-FLD for the Determination of Zearalenone in Corn Oils
by Baoxia Ni, Jin Ye, Zhihong Xuan, Li Li, Xiangrui Wen, Zongwang Li, Hongmei Liu and Songxue Wang
Toxins 2023, 15(5), 337; https://doi.org/10.3390/toxins15050337 - 15 May 2023
Cited by 1 | Viewed by 1283
Abstract
Sample pretreatment is a vital step in the detection of mycotoxins, and traditional pretreatment methods are time-consuming, labor-intensive and generate much organic waste liquid. In this work, an automatic, high-throughput and environmentally friendly pretreatment method is proposed. Immunomagnetic beads technology and dispersive liquid–liquid [...] Read more.
Sample pretreatment is a vital step in the detection of mycotoxins, and traditional pretreatment methods are time-consuming, labor-intensive and generate much organic waste liquid. In this work, an automatic, high-throughput and environmentally friendly pretreatment method is proposed. Immunomagnetic beads technology and dispersive liquid–liquid microextraction technology are combined, and the zearalenone in corn oils is directly purified and concentrated under the solubilization effects of surfactant. The proposed pretreatment method allows for the batch pretreatment of samples without pre-extraction using organic reagents, and almost no organic waste liquid is produced. Coupled with UPLC-FLD, an effective and accurate quantitative detection method for zearalenone is established. The recovery of spiked zearalenone in corn oils at different concentrations ranges from 85.7 to 89.0%, and the relative standard deviation is below 2.9%. The proposed pretreatment method overcomes the shortcomings of traditional pretreatment methods and has broad application prospects. Full article
(This article belongs to the Special Issue Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine Processing)
►▼ Show Figures

Figure 1

15 pages, 1543 KiB  
Article
Centrifugation-Assisted Solid-Phase Extraction Coupled with UPLC-MS/MS for the Determination of Mycotoxins in ARECAE Semen and Its Processed Products
by Huanyan Liang, Qianyu Hou, Yakui Zhou, Lei Zhang, Meihua Yang and Xiangsheng Zhao
Toxins 2022, 14(11), 742; https://doi.org/10.3390/toxins14110742 - 29 Oct 2022
Cited by 2 | Viewed by 1641
Abstract
Mycotoxins can occur naturally in a variety of agriculture products, including cereals, feeds, and Chinese herbal medicines (TCMs), via pre- and post-harvest contamination and are regulated worldwide. However, risk mitigation by monitoring for multiple mycotoxins remains a challenge using existing methods due to [...] Read more.
Mycotoxins can occur naturally in a variety of agriculture products, including cereals, feeds, and Chinese herbal medicines (TCMs), via pre- and post-harvest contamination and are regulated worldwide. However, risk mitigation by monitoring for multiple mycotoxins remains a challenge using existing methods due to their complex matrices. A multi-toxin method for 22 mycotoxins (aflatoxin B1, B2, G1, G2, M1, M2; ochratoxin A, B, C; Fumonisin B1, B2, B3; 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, diace-toxyscirpenol, HT-2, T-2, deepoxy-deoxynivalenol, deoxynivalenol, neosolaniol, zearalenone, and sterigmatocystin) using centrifugation-assisted solid-phase extraction (SPE) clean-up prior to ultra-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) analysis for Arecae Semen and its processed products was developed and validated. Several experimental parameters affecting the extraction and clean-up efficiency were systematically optimized. The results indicated good linearity in the range of 0.1–1000 μg/kg (r2 > 0.99), low limits of detection (ranging from 0.04 μg/kg to 1.5 μg/kg), acceptable precisions, and satisfactory recoveries for the selected mycotoxins. The validated method was then applied to investigate mycotoxin contamination levels in Areca catechu and its processed products. The mycotoxins frequently contaminating Areca catechu were aflatoxins (AFs), and the average contamination level and number of co-occurring mycotoxins in the Arecae Semen slices (Binlangpian) were higher than those in commercially whole Arecae Semen and Arecae Semen Tostum (Jiaobinlang). Sterigmatocystin was detected in 5 out of 30 Arecae Semen slices. None of the investigated mycotoxins were detected in Arecae pericarpium (Dafupi). The results demonstrated that centrifugation-assisted SPE coupled with UHPLC-MS/MS can be a useful tool for the analysis of multiple mycotoxins in Areca catechu and its processed products. Full article
(This article belongs to the Special Issue Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine Processing)
►▼ Show Figures

Figure 1

Review

Jump to: Research

15 pages, 578 KiB  
Review
Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods
by Lijuan Ding, Meihua Han, Xiangtao Wang and Yifei Guo
Toxins 2023, 15(9), 565; https://doi.org/10.3390/toxins15090565 - 08 Sep 2023
Cited by 8 | Viewed by 3492
Abstract
Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicity, and teratogenic mutagenesis, it is essential to [...] Read more.
Ochratoxins are the secondary metabolites of Penicillium and Aspergillus, among which ochratoxin A (OTA) is the most toxic molecule. OTA is widely found in food and agricultural products. Due to its severe nephrotoxicity, immunotoxicity, neurotoxicity, and teratogenic mutagenesis, it is essential to develop effective, economical, and environmentally friendly methods for OTA decontamination and detoxification. This review mainly summarizes the application of technology in OTA prevention, removal, and detoxification from physical, chemical, and biological aspects, depending on the properties of OTA, and describes the advantages and disadvantages of each method from an objective perspective. Overall, biological methods have the greatest potential to degrade OTA. This review provides some ideas for searching for new strains and degrading enzymes. Full article
(This article belongs to the Special Issue Last Studies on Mycotoxins’ Fate during Food and Herbal Medicine Processing)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-5
Back to TopTop