Special Issue "Marine Toxins Affecting Neuronal Function"
Deadline for manuscript submissions: 31 July 2019
Dr. Paz Otero
Department of Pharmacology, Faculty of Veterinary, University of Santiago of Compostela, 27002 Lugo, Spain
Marine neurotoxins, such as domoic acid and analogs, ciguatoxins, tetrodotoxins, saxitoxins, brevetoxins, palytoxins and azaspiracids, among others, are natural products produced by phytoplankton and some species of invertebrates, fish and bacteria. These compounds have many different mechanisms of action, but most of them can interact either with the main voltage-gated channels and thus modulate the flux of ions into various cell types. Other marine toxins, such as domoic acid or BMMA, may interact with the main neurotransmitter receptors affecting normal brain functioning and inducing health risks or even death. This Special Issue will cover all marine neurotoxins that might affect neurological function. Several aspects related to these toxins, including analytical methods for detection and quantification, rapid tests for screening, in vivo and in vitro toxicology, mode of action, occurrence, epidemiology, and effects on neuronal function and brain development, as well as their relevance for the development of age-related brain diseases are considered as the main areas of interest. Moreover, the chronic effects of low doses of neurotoxins on animal and human health are also of interest. In addition the role of compounds of marine origin to develop therapeutic tools against brain-related diseases is also a captivating aspect that fits on the scope of this Special Issue.
Dr. Carmen Vale
Dr. Paz Otero
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Developmental Neurotoxicity
- voltage gated channels
- neurotransmitter receptors
- detection methods
- amnesic toxins
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: MARINE TOXINS AND NOCICEPTION: POTENTIAL THERAPEUTIC USE IN THE TREATMENT OF VISCERAL PAIN ASSOCIATED WITH GASTROINTESTINAL DISORDERS
Authors: Andreina Baja, Bistoletti Michelaa, Elisabetta Morob, Giaroni Cristinaa, Francesca Cremab
aDepartment of Medicine and Surgery, University of Insubria, via H. Dunant 5, I-21100 Varese, Italy
bDepartment of Internal Medicine and Therapeutics, Section of Pharmacology via Ferrata 9, I-27100 Pavia, Italy
Visceral pain is a hallmark symptom of both organic gastrointestinal disorders, such as inflammatory bowel disease (IBD), and functional disorders with an unknown etiology and /or pathogenesis, such as irritable bowel syndrome (IBS). Pain perception is accomplished by activation of central, spinal and local mechanisms. Intrinsic sensory neurons in the enteric nervous system and afferent sensory neurons of the dorsal root ganglia, connecting with the central nervous system, represent the primary afferents underlaying gastrointestinal visceral pain perception. Numerous cellular targets, such as voltage-gated ion channels and receptors for different neurotransmitters/neuromodulators, such as vanilloids, glutamate, GABA, acetylcholine, tachykinins, purines are present on these neuronal pathways. Recently a conspicuous number of studies have demonstrated that marine toxins, such as tetrodotoxin and conotoxins, by interacting with some of these targets, may represent a possible tool to modulate visceral pain perception. In this review we consider the physiological basis of marine toxin action on gastrointestinal visceral pain and the possible clinical implications in the treatment of chronic pain associated with gut diseases.