Special Issue "Toxins: The New Frontier for Understanding the Barrier between Commensalism and Pathogenicity?"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 11183
Interests: bacterial toxins; genotoxicity; pathogenicity; enterobacteria
Special Issues, Collections and Topics in MDPI journals
By definition, toxins are toxic substances produced by a microorganism and responsible for its ability to cause disease. They have long been considered only as virulence factors having a deleterious effect on the host during acute infections. The fact that these toxins can be produced by nonpathogenic microorganisms and/or in asymptomatic carriers shows that we have often taken an overly simplistic approach to the role of these biologically very active molecules. Without paraphrasing Paracelsus who said that only the dose makes the poison, we must reconsider the role of these toxins not only during an acute infection, but also during the so-called asymptomatic carriage. At more “physiological” doses, toxins could have a totally different role and promote colonization by modulating the response of the host or the microbiota. However, like any drug, these substances have harmful side effects for the host, even without acute infections, in particular physiological contexts (inflammation, dysbiosis, etc.), during synergies with other xenobiotics or food contaminants, or simply because of the duration and recurrence of exposure (DNA damage, etc.). The production of these toxins can then play a role in the development of cancers, chronic inflammatory diseases, metabolic diseases, etc. Finally, we must also get away from a vision that focuses too much on the infection, which in fact represents a very short period of the life of a pathogenic microorganism. We too often forget that these microorganisms can have different hosts and reservoirs that play a crucial role in the infectious cycle. They can go through cycles in the environment where they fall prey to predators that may become future vectors for the spread of a pathogenic microorganism.
The aim of this Special Issue is therefore to review the role of these toxins from an angle that takes into account both the complexity of the infectious cycle of toxigenic microorganisms and the diversity of the effects of these toxins on the host, but also on the microbiota.
Prof. Dr. Eric Oswald
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Infectious cycle
- Metabolic diseases