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Toxins
Special Issues
Toxins and Infectious Diseases
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Toxins and Infectious Diseases

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3438

Special Issue Editors

Dr. Alvaro Mourenza Flórez

E-Mail Website
Guest Editor
1. Department of Molecular Biology, Area of Microbiology, Universidad de León, 24071 Leon, Spain
2. Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA
Interests: infectious diseases; intracellular pathogens; redox biology; protein-protein interaction inhibitors
Special Issues, Collections and Topics in MDPI journals
Dr. Michal Letek

E-Mail Website
Guest Editor
Department of Molecular Biology, Area of Microbiology, Universidad de León, 24071 Leon, Spain
Interests: intracellular pathogens; genome evolution; drug screening; redox biology; drug repurposing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Toxins are one of the most common virulence factors produced by different human pathogens. Moreover, toxins are used by bacteria to colonize different environments. Therefore, toxins can also be used as scaffolds to develop new antimicrobial treatments. This Special Issue will focus on the role of toxins and anti-toxin compounds in human health. We invite you to present the latest research in the field of toxins, treatments against them and any point of view that can highlight the importance of the use of some toxins as new scaffolds for antimicrobial treatments. We look forward to receiving your contributions.

Dr. Alvaro Mourenza Flórez
Dr. Michal Letek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • toxins
  • human pathogens
  • anti-toxins

Published Papers (1 paper)

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Research

16 pages, 1756 KiB  
Article
Botulism in Spain: Epidemiology and Outcomes of Antitoxin Treatment, 1997–2019
by Marina Peñuelas, María Guerrero-Vadillo, Sylvia Valdezate, María Jesús Zamora, Inmaculada Leon-Gomez, Ángeles Flores-Cuéllar, Gema Carrasco, Oliva Díaz-García and Carmen Varela
Toxins 2023, 15(1), 2; https://doi.org/10.3390/toxins15010002 - 20 Dec 2022
Cited by 2 | Viewed by 2815
Abstract
Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum. There are different routes of acquisition, food-borne and infant/intestinal being the most frequent presentation, and antitoxin is the treatment of choice in all [...] Read more.
Background: Botulism is a low incidence but potentially fatal infectious disease caused by neurotoxins produced mainly by Clostridium botulinum. There are different routes of acquisition, food-borne and infant/intestinal being the most frequent presentation, and antitoxin is the treatment of choice in all cases. In Spain, botulism is under surveillance, and case reporting is mandatory. Methods: This retrospective study attempts to provide a more complete picture of the epidemiology of botulism in Spain from 1997 to 2019 and an assessment of the treatment, including the relationship between a delay in antitoxin administration and the length of hospitalization using the Cox proportional hazards test and Kruskal–Wallis test, and an approach to the frequency of adverse events, issues for which no previous national data have been published. Results: Eight of the 44 outbreaks were associated with contaminated commercial foods involving ≤7 cases/outbreak; preserved vegetables were the main source of infection, followed by fish products; early antitoxin administration significantly reduces the hospital stay, and adverse reactions to the antitoxin affect around 3% of treated cases. Full article
(This article belongs to the Special Issue Toxins and Infectious Diseases)
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