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Technologies
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Medical Imaging & Image Processing
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Medical Imaging & Image Processing

A special issue of Technologies (ISSN 2227-7080). This special issue belongs to the section "Information and Communication Technologies".

Deadline for manuscript submissions: closed (31 March 2015) | Viewed by 40123

Special Issue Editors

Prof. Dr. Yudong Zhang

grade E-Mail Website
Guest Editor
Informatics Building School of Informatics, University of Leicester, Leicester LE1 7RH, UK
Interests: explainable deep learning; medical image analysis; pattern recognition and medical sensors; artificial intelligence; intelligent computing
Special Issues, Collections and Topics in MDPI journals
Dr. Zhengchao Dong

E-Mail Website
Guest Editor
1. Professor, Molecular Imaging and Neuropathology Division, Columbia University, New York, NY 10032, USA
2. Research Scientist, New York State Psychiatric Institute, New York, NY 10032, USA
Interests: magnetic resonance spectroscopy imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Medical Imaging has become an essential component in many fields of bio-medical research and clinical practice. Biologists study cells and generate 3D confocal microscopy data sets, virologists generate 3D reconstructions of viruses from micrographs, radiologists identify and quantify tumors from MRI and CT scans, and neuroscientists detect regional metabolic brain activity from PET and functional MRI scans.

Image Processing includes the analysis, enhancement and display of images captured via various medical imaging technologies. Image reconstruction and modeling techniques allow instant processing of 2D signals to create 3D images. In addition, image processing and analysis can be used to determine the diameter, volume and vasculature of a tumor or organ, flow parameters of blood or other fluids and microscopic changes that have yet to raise any otherwise discernible flags.

Prof. Dr. Yudong Zhang
Dr. Zhengchao Dong
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Technologies is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


Keywords

  • medical imaging
  • biological imaging
  • magnetic resonance imaging
  • neuroimaging
  • computerized tomography
  • image processing & analysis
  • machine learning
  • pattern recognition

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Related Special Issue

Published Papers (5 papers)

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Editorial

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2 pages, 604 KiB  
Editorial
Special Issue on “Medical Imaging and Image Processing”
by Yudong Zhang and Zhengchao Dong
Technologies 2014, 2(4), 164-165; https://doi.org/10.3390/technologies2040164 - 19 Dec 2014
Viewed by 5239
Abstract
Over the last decade, Medical Imaging has become an essential component in many fields of bio-medical research and clinical practice. Biologists study cells and generate 3D confocal microscopy data sets, virologists generate 3D reconstructions of viruses from micrographs, radiologists identify and quantify tumors [...] Read more.
Over the last decade, Medical Imaging has become an essential component in many fields of bio-medical research and clinical practice. Biologists study cells and generate 3D confocal microscopy data sets, virologists generate 3D reconstructions of viruses from micrographs, radiologists identify and quantify tumors from MRI and CT scans, and neuroscientists detect regional metabolic brain activity from PET and functional MRI scans. On the other hand, Image Processing includes the analysis, enhancement, and display of images captured via various medical imaging technologies. Image reconstruction and modeling techniques allow instant processing of 2D signals to create 3D images. In addition, image processing and analysis can be used to determine the diameter, volume, and vasculature of a tumor or organ, flow parameters of blood or other fluids, and microscopic changes that have not previously been discernible.[...] Full article
(This article belongs to the Special Issue Medical Imaging & Image Processing)

Research

Jump to: Editorial

19 pages, 273 KiB  
Article
A New Compton Camera Imaging Model to Mitigate the Finite Spatial Resolution of Detectors and New Camera Designs for Implementation
by Bruce Smith
Technologies 2015, 3(4), 219-237; https://doi.org/10.3390/technologies3040219 - 27 Oct 2015
Cited by 2 | Viewed by 5662
Abstract
An intrinsic limitation of the accuracy that can be achieved with Compton cameras results from the inevitable fact that the detectors, which comprise the camera, cannot have infinitely-accurate spatial resolution. To mitigate this loss of accuracy, a new imaging model is proposed. The [...] Read more.
An intrinsic limitation of the accuracy that can be achieved with Compton cameras results from the inevitable fact that the detectors, which comprise the camera, cannot have infinitely-accurate spatial resolution. To mitigate this loss of accuracy, a new imaging model is proposed. The implementation of the new imaging model, however, requires new camera designs. The results of a computer simulation indicate that the new imaging model can produce reasonable images, at least when noiseless simulated data are used. In the future, more work is needed to determine if the use of the new imaging model will improve the imaging capabilities of Compton cameras despite the loss of sensitivity caused by the use of the new camera designs. Regardless of the outcome of this work, the results presented here illustrate that new models for imaging from Compton scatters are possible and motivate the development of further models that could be more advantageous than the ones already developed. Full article
(This article belongs to the Special Issue Medical Imaging & Image Processing)
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20 pages, 2261 KiB  
Article
Automated Segmentation of MS Lesions in MR Images Based on an Information Theoretic Clustering and Contrast Transformations
by Jason Hill, Kevin Matlock, Brian Nutter and Sunanda Mitra
Technologies 2015, 3(2), 142-161; https://doi.org/10.3390/technologies3020142 - 5 Jun 2015
Cited by 10 | Viewed by 6947
Abstract
Magnetic Resonance Imaging (MRI) plays a significant role in the current characterization and diagnosis of multiple sclerosis (MS) in radiological imaging. However, early detection of MS lesions from MRI still remains a challenging problem. In the present work, an information theoretic approach to [...] Read more.
Magnetic Resonance Imaging (MRI) plays a significant role in the current characterization and diagnosis of multiple sclerosis (MS) in radiological imaging. However, early detection of MS lesions from MRI still remains a challenging problem. In the present work, an information theoretic approach to cluster the voxels in MS lesions for automatic segmentation of lesions of various sizes in multi-contrast (T1, T2, PD-weighted) MR images, is applied. For accurate detection of MS lesions of various sizes, the skull-stripped brain data are rescaled and histogram manipulated prior to mapping the multi-contrast data to pseudo-color images. For automated segmentation of multiple sclerosis (MS) lesions in multi-contrast MRI, the improved jump method (IJM) clustering method has been enhanced via edge suppression for improved segmentation of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and MS lesions if present. From this preliminary clustering, a pseudo-color to grayscale conversion is designed to equalize the intensities of the normal brain tissues, leaving the MS lesions as outliers. Binary discrete and 8-bit fuzzy labels are then assigned to segment the MS lesions throughout the full brain. For validation of the proposed method, three brains, with mild, moderate and severe hyperintense MS lesions labeled as ground truth, were selected. The MS lesions of mild, moderate and severe categories were detected with a sensitivity of 80%, and 96%, and 94%, and with the corresponding Dice similarity coefficient (DSC) of 0.5175, 0.8739, and 0.8266 respectively. The MS lesions can also be clearly visualized in a transparent pseudo-color computer rendered 3D brain. Full article
(This article belongs to the Special Issue Medical Imaging & Image Processing)
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16 pages, 1965 KiB  
Article
Medical Image Processing for Fully Integrated Subject Specific Whole Brain Mesh Generation
by Chih-Yang Hsu, Ben Schneller, Mahsa Ghaffari, Ali Alaraj and Andreas Linninger
Technologies 2015, 3(2), 126-141; https://doi.org/10.3390/technologies3020126 - 21 May 2015
Cited by 18 | Viewed by 11817
Abstract
Currently, anatomically consistent segmentation of vascular trees acquired with magnetic resonance imaging requires the use of multiple image processing steps, which, in turn, depend on manual intervention. In effect, segmentation of vascular trees from medical images is time consuming and error prone due [...] Read more.
Currently, anatomically consistent segmentation of vascular trees acquired with magnetic resonance imaging requires the use of multiple image processing steps, which, in turn, depend on manual intervention. In effect, segmentation of vascular trees from medical images is time consuming and error prone due to the tortuous geometry and weak signal in small blood vessels. To overcome errors and accelerate the image processing time, we introduce an automatic image processing pipeline for constructing subject specific computational meshes for entire cerebral vasculature, including segmentation of ancillary structures; the grey and white matter, cerebrospinal fluid space, skull, and scalp. To demonstrate the validity of the new pipeline, we segmented the entire intracranial compartment with special attention of the angioarchitecture from magnetic resonance imaging acquired for two healthy volunteers. The raw images were processed through our pipeline for automatic segmentation and mesh generation. Due to partial volume effect and finite resolution, the computational meshes intersect with each other at respective interfaces. To eliminate anatomically inconsistent overlap, we utilized morphological operations to separate the structures with a physiologically sound gap spaces. The resulting meshes exhibit anatomically correct spatial extent and relative positions without intersections. For validation, we computed critical biometrics of the angioarchitecture, the cortical surfaces, ventricular system, and cerebrospinal fluid (CSF) spaces and compared against literature values. Volumina and surface areas of the computational mesh were found to be in physiological ranges. In conclusion, we present an automatic image processing pipeline to automate the segmentation of the main intracranial compartments including a subject-specific vascular trees. These computational meshes can be used in 3D immersive visualization for diagnosis, surgery planning with haptics control in virtual reality. Subject-specific computational meshes are also a prerequisite for computer simulations of cerebral hemodynamics and the effects of traumatic brain injury. Full article
(This article belongs to the Special Issue Medical Imaging & Image Processing)
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8 pages, 824 KiB  
Article
A Hybrid Feature Extractor using Fast Hessian Detector and SIFT
by Mehmet Serdar Güzel
Technologies 2015, 3(2), 103-110; https://doi.org/10.3390/technologies3020103 - 15 May 2015
Cited by 9 | Viewed by 8322
Abstract
This paper addresses a new hybrid feature extractor algorithm, which in essence integrates a Fast-Hessian detector into the SIFT (Scale Invariant Feature Transform) algorithm. Feature extractors mainly consist of two essential parts: feature detector and descriptor extractor. This study proposes to integrate (Speeded-Up [...] Read more.
This paper addresses a new hybrid feature extractor algorithm, which in essence integrates a Fast-Hessian detector into the SIFT (Scale Invariant Feature Transform) algorithm. Feature extractors mainly consist of two essential parts: feature detector and descriptor extractor. This study proposes to integrate (Speeded-Up Robust Features) SURF’s hessian detector into the SIFT algorithm so as to boost the total number of true matched pairs. This is a critical requirement in image processing and widely used in various corresponding fields from image stitching to object recognition. The proposed hybrid algorithm has been tested under different experimental conditions and results are quite encouraging in terms of obtaining higher matched pairs and precision score. Full article
(This article belongs to the Special Issue Medical Imaging & Image Processing)
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