Nasal Polyposis in Chronic Rhinosinusitis: Recent Advances in Diagnosis and Management

Dear Colleagues,

Nasal polyposis, a hallmark feature of certain forms of chronic rhinosinusitis (CRS), represents a significant clinical challenge due to its complex pathophysiology, high recurrence rate, and impact on patients' quality of life. As a subtype of CRS, chronic rhinosinusitis with nasal polyps (CRSwNP) is increasingly recognized as a heterogeneous inflammatory disorder that involves multifactorial etiologies, including immune dysregulation, epithelial barrier dysfunction, microbial influences, and genetic susceptibility.

Recent years have seen important advances in our understanding of nasal polyposis, driven by progress in molecular biology, imaging techniques, and immunological profiling. The emergence of endotyping and biomarker discovery has opened the door to more personalized approaches to diagnosis and treatment. Meanwhile, biologic therapies targeting type 2 inflammation are revolutionizing management strategies and providing new hope for patients with severe or refractory disease.

This Special Issue aims to bring together original research and review articles that explore the latest developments in the diagnosis, pathophysiology, and management of nasal polyposis within the broader context of chronic rhinosinusitis. We particularly welcome submissions that address the following:

• The link between nasal polyposis and obstructive sleep apnea;
• Comorbid nasal polyposis and allergic rhinitis;
• The interplay between nasal polyposis and asthma;
• Novel biomarkers for disease endotyping, prognosis, and treatment response;
• Advancements in imaging and diagnostic modalities;
• Outcomes and efficacy of biologic therapies;
• Surgical approaches and postoperative care strategies;
• Environmental or occupational factors contributing to disease progression.

We invite clinicians, researchers, and translational scientists to contribute to this Special Issue and help shape the future of personalized care for patients with nasal polyposis and chronic rhinosinusitis.

Prof. Dr. Sy Duong-Quy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sinusitis is an international peer-reviewed open access semiannually journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nasal polyposis
• chronic rhinosinusitis
• CRSwNP
• type 2 inflammation
• biomarkers
• obstructive sleep apnea
• allergic rhinitis
• asthma
• personalized medicine
• sinus surgery
• mucosal immunology
• nasal polyps diagnosis
• upper airway inflammation.