Separations by Differential Mobility Spectrometry–Recent Advances in Applications and Theory

A special issue of Separations (ISSN 2297-8739).

Deadline for manuscript submissions: closed (8 January 2022) | Viewed by 2592

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Waterloo, Waterloo, ON, Canada
Interests: mass spectrometry; chromatography; environmental analytical chemistry; liquid chromatography; sample preparation; analytical chemistry instrumentation; proteomics; analytical method development; instrumental analysis; high-performance liquid chromatography

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Guest Editor
Department of Chemistry, University of Waterloo, Waterloo, ON, Canada
Interests: physical chemistry; structures and reactivities of small nanocluster systems

Special Issue Information

Dear Colleagues,

Differential mobility spectrometry (DMS) is a powerful ion mobility technique that can separate ions of analytical interest from interfering chemical noise, as well as isomeric variants. This technology, when coupled with mass spectrometry, provides superior analytical performance especially when chemical noise hampers the desired limits of detection. However, there is much more to DMS (also known as FAIMS) than serving as a “chemical filter”. With DMS-MS, we have begun to understand the roles of ion solvation on predicting the bulk properties of molecules, as well as other fundamental properties of these systems. In this issue, we present a collection of papers from authors experienced in the application and development of DMS technology, who have advanced both the analytical and theoretical understanding of this exciting technology.

Dr. J. Larry Campbell
Dr. Scott Hopkins
Guest Editors

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Keywords

  • differential mobility spectrometry
  • DMS
  • high field asymmetric ion mobility spectrometry
  • FAIMS
  • mass spectrometry
  • ion mobility
  • separations
  • ion solvation
  • isomer separation

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Published Papers (1 paper)

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Research

10 pages, 1872 KiB  
Article
A Tapered Capillary-Based Contactless Atmospheric Pressure Ionization Mass Spectrometry for On-Line Preconcentration and Separation of Small Organics
by Yen-Chun Chen, Arun Krishnamurthy, Szu-Hua Chen and Yu-Chie Chen
Separations 2021, 8(8), 111; https://doi.org/10.3390/separations8080111 - 29 Jul 2021
Cited by 5 | Viewed by 2165
Abstract
Capillary electrophoresis (CE) is an effective technique for the separation of different analytes. Moreover, online preconcentration of trace analytes in the capillary for CE analysis has been demonstrated. CE and capillary electrochromatography (CEC) are suitable for the separation of analytes with similar polarities. [...] Read more.
Capillary electrophoresis (CE) is an effective technique for the separation of different analytes. Moreover, online preconcentration of trace analytes in the capillary for CE analysis has been demonstrated. CE and capillary electrochromatography (CEC) are suitable for the separation of analytes with similar polarities. Given that CE and CEC are only used to separate small-volume samples, sensitive mass spectrometry (MS) is a suitable detection tool for CE and CEC. Contactless atmospheric pressure ionization (C-API) is a continuous flow ion source that only uses a short capillary as the ionization emitter operated at atmospheric pressure for MS analysis. In this study, we demonstrated the feasibility of hyphenating CE/CEC with C-API-MS by using a short and tapered capillary as the interface. The short capillary (a few centimeters) can function as the separation/preconcentration tube and the ionization emitter. This hyphenated technique can be used to analyze small organics within a few minutes. The suitability of using the hyphenated technique for online preconcentration, separation, and quantitative analysis for small organics is demonstrated in this study. Full article
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